Article
Neurosciences
Faizan Ul Haq, Mohammad Shoaib, Syed Wadood Ali Shah, Haya Hussain, Muhammad Zahoor, Riaz Ullah, Ahmed Bari, Amal Alotaibi, Muhammad Faisal Hayat
Summary: This study aimed to synthesize benzodiazepine derivatives and evaluate their antidepressant potentials. The results showed that compounds 2 and 5 exhibited significant antidepressant effects and increased GABA levels in the brain's hippocampus of experimental animals, indicating the possible involvement of the GABAergic mechanism.
Article
Biochemistry & Molecular Biology
Najeeb Ur Rehman, Sulaiman Al-Shidhani, Nasiara Karim, Ajmal Khan, Imran Khan, Sobia Ahsan Halim, Sajid Khan Sadozai, Satya Kumar Avula, Rene Csuk, Ahmed Al-Harrasi
Summary: Through the study of derivatives of two active substances in the resin of Boswellia papyrifera, it is found that these derivatives have good anti-depressive properties and have great application potential. Further research indicates that these compounds produce GABAergic effects by binding to the GABA binding site of the GABA(A) receptor.
BIOORGANIC CHEMISTRY
(2022)
Article
Integrative & Complementary Medicine
Sun Dan-chen, Wang Ran-ran, Xu Hao, Zhu Xue-hui, Sun Yan, Qiao Shi-qing, Qiao Wei
Summary: This study investigated the pharmacodynamic material basis, mechanism of actions, and targeted diseases of Salicornia europaea L. (SE) using the network pharmacology method. Pharmacological experiments verified the antidepressant-like effect of SE extract and suggested that it may regulate the Nrf2-ARE pathway and increase levels of dopamine and corticosterone in the hippocampus and cortex.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Behavioral Sciences
Marcela Pereira, Isadora P. Siba, Alexandra Acco, Diego Correia, Fernanda R. Lapa, Adair R. S. Santos, Ana P. Ruani, Moacir G. Pizzolatti, Roberto Andreatini
Summary: The study found that myricitrin can reverse depressive behavior induced by chronic mild stress and reduce adrenal hypertrophy and levels of the inflammatory cytokine IL-6 in the hippocampus. This suggests that myricitrin has antidepressant and anti-inflammatory effects.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Behavioral Sciences
Aida A. C. Brandao, Deborah L. S. Deus, Luiz A. M. S. Duarte-Filho, Pedro M. N. Menezes, Ana B. R. Massaranduba, Fabricio S. Silva, Luciano A. A. Ribeiro
Summary: Through nebulization delivery, ketamine can significantly reduce depressive-like behaviors in mice, indicating that nebulization can be an effective and inexpensive route of drug administration for behavioral research.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Rohit Pal, Bhupinder Kumar, P. M. Guruubasavaraja Swamy, Pooja A. Chawla
Summary: A series of substituted-N-(5,6-diphenyl-1,2,4-triazin-3-yl) benzamides were designed, synthesized, and evaluated for their antidepressant-like activity. Compound R:5 and R:9 exhibited potent MAO-A inhibition activity and significant antidepressant effects in FST and TST. ADME and docking studies further confirmed their pharmacological characteristics and binding abilities.
BIOORGANIC CHEMISTRY
(2023)
Article
Neurosciences
Zhicheng Jin, Jianer Ling, Jing Yu, Mengzi He, Pingping Ni, Fang Zhang, Yizhen Wang
Summary: The study revealed that hypothyroidism induces depressive behaviors, with the influence of the serotonin system playing a significant role, and the decreased expression of the 5-HT2A receptor being a crucial factor in the depressive behaviors associated with hypothyroidism.
EXPERIMENTAL BRAIN RESEARCH
(2021)
Article
Chemistry, Analytical
Imane Maliki, Imane Es-safi, Abdelfattah El Moussaoui, Hamza Mechchate, Yassine Oulad El Majdoub, Aziz Bouymajane, Francesco Cacciola, Luigi Mondello, Khalid Elbadaoui
Summary: This study found that the aqueous extracts of Salvia officinalis and Lippia triphylla have significant antidepressant effects in mice in the forced swimming test and tail suspension test.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Pharmacology & Pharmacy
Yusuf S. Althobaiti
Summary: Addiction to drugs and chemicals is a global public health concern. The prescription medication mirtazapine (MIRT) has been reported to be abused and can induce withdrawal symptoms. In this study using mice, it was found that MIRT can induce drug-seeking behavior, impair recognition, and cause withdrawal symptoms. These findings suggest that MIRT may have the potential to induce drug dependence.
SAUDI PHARMACEUTICAL JOURNAL
(2022)
Article
Neurosciences
Arnab Nandi, Garima Virmani, Aatmika Barve, Swananda Marathe
Summary: FST and TST are common behavioral tests for screening antidepressant drugs and assessing non-motor symptoms in movement disorder animal models. Manual analysis of these tests is time-consuming with large variability, but the open-source program DBscorer provides automated and unbiased analysis, allowing for a nuanced understanding of behavioral despair expression.
Article
Endocrinology & Metabolism
Uzma Saleem, Shafa Iman, Bashir Ahmad, Muhammad Ajmal Shah, Shabana Bibi, Mohammed Alqarni, Muhammad Saad Khan, Ghulam Mujtaba Shah, Haroon Khan, Reem Hasaballah Alhasani, Norah A. Althobaiti, Aishah E. Albalawi
Summary: This study aimed to investigate the antidepressant properties of mango seeds in animals and confirm its effectiveness through molecular docking. The results showed that mango seed extract improved physical activity and biochemical parameters in mice. Additionally, catechin was found to be a potential antidepressant agent. Therefore, mango seeds could be a significant alternative therapy for depression.
METABOLIC BRAIN DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Teresa Taboada, Nelson L. Alvarenga, Antonia K. Galeano, Wilfrido J. Arrua, Miguel A. Campuzano-Bublitz, Maria L. Kennedy
Summary: This study evaluated the antidepressant effects of ethanolic extracts from Aloysia gratissima var. gratissima and Aloysia virgata var. platyphylla in mice, demonstrating promising results in reducing immobility time in both animal models. LCMS analysis revealed the presence of verbascoside, hoffmaniaketone, and hoffmaniaketone acetate in both extracts, with flavonoids nepetin and 6-hydroxyluteolin found in A. gratissima var. gratissima.
Article
Chemistry, Medicinal
Qiu-Wan Tan, Li-Ya He, Zhi-Wen He, Wei-Hua Liu, Shan-Shan Zhang, Lin Lin, Hong-Li Yang, Li-Ping Guan
Summary: Nineteen 3H-benzo[f]chromen chalcone derivatives were synthesized and evaluated for their antidepressant and anticonvulsant activities in mice. The compounds showed promising results with significant antidepressant and anticonvulsant properties, laying a foundation for the discovery of new antidepressants with high biological activity and minimal side effects.
MEDICINAL CHEMISTRY RESEARCH
(2021)
Article
Behavioral Sciences
Joanna Kowalczyk, Modestos Nakos-Bimpos, Alexia Polissidis, Christina Dalla, Nikolaos Kokras, Krystyna Skalicka-Wozniak, Barbara Budzynska
Summary: This study found that xanthotoxin can reduce depressive behaviors in male mice, while female mice have lower immobility levels compared to males, which may be related to higher levels of serotonin in the female prefrontal cortex. Additionally, xanthotoxin can lead to a dose-dependent increase in serotonin and noradrenaline levels in the female prefrontal cortex.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Barbara G. Ferri, Cintia O. de Novais, Raquel S. Bonani, Wellington A. de Barros, Angelo de Fatima, Fabiana C. Vilela, Alexandre Giusti-Paiva
Summary: This study assessed the effect of the psychedelic substances 25HNBOMe and 25H-NBOH on the depressive-like behavior of male adult rats. The results showed that these synthetic psychedelic substances exhibited hallucinogenic effects, and both 25H-NBOMe and 25H-NBOH produced a significantly greater motivation to escape in the forced swimming test. The study provides new insights into the antidepressant properties of a single dose of both 25H-NBOMe and 25H-NBOH.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)