期刊
PROGRESS IN LIPID RESEARCH
卷 47, 期 6, 页码 405-421出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.plipres.2008.05.001
关键词
Acyl-CoA thioesterases; Peroxisomes; Acyl-CoA; Acyltransferases; Coenzyme A; Alpha-oxidation; Beta-oxidation; Omega-oxidation
资金
- Swedish Research Council
- FP6 European Union Project Peroxisome [LSHG-CT-2004-512018]
- AFA sjukforsakrings jubileumsstiftelse
- Ake Wibergs stiftelse
- Lars Hiertas Minne
- Fredrik and Ingrid Thurings Stiftelse
- Ruth and Richard Julins Stiftelse
- Stiftelsen Professor Nanna Svartz fond
Peroxisomes are single membrane bound organelles present in almost all eukaryotic cells, and to date have been shown to contain approximately 60 identified enzymes involved in various metabolic pathways, including the oxidation of a variety of lipids. These lipids include very long-chain fatty acids, methyl branched fatty acids, prostaglandins, bile-acid precursors and xenobiotics that are either beta-oxidized or alpha-oxidized in peroxisomes. The recent identification of several acyl-CoA thioesterases and acyltransferases in peroxisomes has revealed their various functions in acting as auxiliary enzymes in alpha and beta-oxidation in this organelle. To date, 9 functional acyl-CoA thioesterases and acyltransferases have been identified in mouse and 4 functional acyl-CoA thioesterases and acyltransferases in human, thus these enzymes make up a substantial portion of peroxisomal proteins. This review will therefore focus on new and emerging roles for these enzymes in assisting with the oxidation of various lipids, amidation of lipids for excretion from peroxisomes, and in controlling coenzyme A levels in peroxisomes. (C) 2008 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据