Article
Multidisciplinary Sciences
Jugroop Singh, Aldwin Pagulayan, Brian A. Camley, Amrinder S. Nain
Summary: The study shows that rules controlling cell-cell collisions on suspended nanofibers differ significantly from CIL behavior on 2D substrates. Fiber geometry modulates cell behavior, with cell-cell adhesion identified as a key mediator of collision outcomes. The geometry of the fiber can generate entirely new behaviors that cannot be predicted from interactions on flat substrates or micropatterns.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
David B. Brueckner, Nicolas Arlt, Alexandra Fink, Pierre Ronceray, Joachim O. Raedler, Chase P. Broedersz
Summary: The study found that the interactions between noncancerous cells are mainly described by repulsion and friction interactions, while cancerous cells exhibit attraction and antifriction interactions. These interaction behaviors were validated in experiments and may provide a unifying theoretical description for diverse cellular interaction behaviors of different cell types.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemical Research Methods
Daisuke Imoto, Nen Saito, Akihiko Nakajima, Gen Honda, Motohiko Ishida, Toyoko Sugita, Sayaka Ishihara, Koko Katagiri, Chika Okimura, Yoshiaki Iwadate, Satoshi Sawai
Summary: This study uses machine learning techniques to extract features, comparing real cell data with outputs of a conceptual model and identifying critical parameters for migratory morphologies. The approach allows systematic and objective comparison of model outputs with real data, providing an important basis for quantitative testing of future mathematical models.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Madhav Mantri, Gaetano J. Scuderi, Roozbeh Abedini-Nassab, Michael F. Z. Wang, David McKellar, Hao Shi, Benjamin Grodner, Jonathan T. Butcher, Iwijn De Vlaminck
Summary: By utilizing single-cell and spatial transcriptomics in chicken hearts, the authors conducted a census of cellular interactions from early to late four-chambered heart stage, identifying a distinct epicardial-mesenchymal cell population with a migratory phenotype.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Mingqi Li, Ling Li, Sarah Asemota, David Kakhniashvili, Ramesh Narayanan, Xusheng Wang, Francesca-Fang Liao
Summary: This study identifies the molecular mechanisms of how the deubiquitinase OTULIN counteracts LUBAC-mediated NF-kappa B activation. The physical interaction between OTULIN and LUBAC is crucial for genotoxic NF-kappa B signaling, and disruption of this interaction leads to NF-kappa B overactivation. These findings have implications for developing therapeutic strategies against cancer chemoresistance and necroptotic processes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Physical
Michael F. Staddon, Michael P. Murrell, Shiladitya Banerjee
Summary: The coordinated and cooperative motion of cells plays a crucial role in embryonic development, tissue morphogenesis, wound healing, and cancer invasion. By developing a predictive cellular vertex model, we can understand the relative roles of substrate rigidity, tissue mechanics, and active cell properties in collective cell motion. Our model predicts that the cooperation of cell crawling and tissue pressure drives faster spreading, with the spreading rate being sensitive to the mechanical properties of the tissue.
Article
Oncology
Giulia Pinton, Zhuo Wang, Cecilia Balzano, Sara Missaglia, Daniela Tavian, Renzo Boldorini, Dean A. Fennell, Martin Griffin, Laura Moro
Summary: Malignant pleural mesothelioma is an aggressive cancer with heterogeneous presentation and behavior, and despite increasing knowledge about molecular markers, they are not fully utilized for treatment allocation. Recent studies have shown that mesothelioma cells lacking BAP1 are sensitive to EZH2 histone methyltransferase inhibition. Manipulating SIRT1 expression and culturing cells as multicellular spheroids can enhance the sensitivity of BAP1 wild-type mesothelioma cells to EPZ-6438, ultimately leading to cell growth arrest and gene expression alterations. Loss of CDKN2A predicts cell fate in response to EZH2 inhibition, suggesting its potential use in stratifying tumors likely to undergo apoptosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Takayuki Kohno, Takumi Konno, Shin Kikuchi, Masuo Kondoh, Takashi Kojima
Summary: This study focused on the mechanism of contact inhibition withdrawal in epithelial cancer precursor cells, identifying a new mechanism for triggering cell growth through tight junction-mediated signaling at cellular junctions.
Article
Multidisciplinary Sciences
Ryota Sakamoto, Ziane Izri, Yuta Shimamoto, Makito Miyazaki, Yusuke T. Maeda
Summary: Cell migration in confined environments is crucial for various biological processes. This study investigates the physical determinants of actomyosin-based migration in confined environments using an in vitro migratory cell model. The results reveal the importance of the physical interaction between actomyosin networks and the cell membrane in generating a propulsive force for cell movement.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Le He, Marie-Pierre Valignat, Lichen Zhang, Lena Gelard, Fanghui Zhang, Valentin Le Guen, Stephane Audebert, Luc Camoin, Even Fossum, Bjarne Bogen, Hui Wang, Sandrine Henri, Romain Roncagalli, Olivier Theodoly, Yinming Liang, Marie Malissen, Bernard Malissen
Summary: The study reveals that ARHGAP45 GAP plays a key role in the lifecycle of T and B cells, controlling cell deformability and motility which affect the entry of cells into lymph nodes and engraftment in the bone marrow.
Review
Engineering, Biomedical
Wenxuan Du, Praful Nair, Adrian Johnston, Pei-Hsun Wu, Denis Wirtz
Summary: Cell migration is a crucial process that regulates human organ development, disease progression and cancer metastasis. The migration of immune and tumor cells is closely associated with immune cell infiltration, immune escape, and tumor cell spread in cancer. Understanding the reciprocal regulation of immune and cancer cell migration mediated by soluble factors can provide valuable insights for the development of biomarkers and treatments for cancer.
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING
(2022)
Review
Cell Biology
Jonathan Kuhn, Yiyan Lin, Peter N. Devreotes
Summary: Dictyostelium discoideum has been a valuable tool for dissecting eukaryotic cell biology due to its short growth cycle and genetic tractability. Recent advances in imaging, synthetic biology, and computational analysis allow researchers to tune the activity of individual molecules in living cells and measure the effects on cellular motility and signaling. This enables a better understanding and control of cell migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Gastroenterology & Hepatology
Seenivasan Boopathi, Danrui Liu, Ai-Qun Jia
Summary: Interactions among bacteria play a crucial role in shaping the structure and function of the gut microbial community, involving both cooperation and competition. Bacteria communicate through various extracellular organelles, sharing beneficial molecules and competing with toxins. Intrinsic coordination between contact-dependent and contact-independent mechanisms provides a fitness advantage and increased colonization resistance to the gut microbiota.
Article
Materials Science, Multidisciplinary
Francesc Perez-Rafols, Jan Steven Van Dokkum, Lucia Nicola
Summary: Viscoelasticity and roughness are the main causes of adhesive hysteresis in soft contacts. When the viscoelasticity is confined to the edges of the contact, the contributions of viscoelasticity and roughness to adhesive hysteresis are nearly independent and additive. At low retraction rates, the instabilities typical of rough elastic contacts are suppressed by viscoelasticity, while at high retraction rates mechanical instabilities appear.
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
(2023)
Review
Biochemistry & Molecular Biology
Maik C. Bischoff, Sven Bogdan
Summary: Collective migration plays a crucial role in development, physiology, and pathophysiology, including tissue repair, wound healing, and cancer. Recent advances in high-resolution and live-cell-imaging techniques have provided new insights into the mechanisms of collective cell migration. Studying various genetic model organisms helps reveal similarities, new features, and principles in collective cell migration.
Article
Cell & Tissue Engineering
Chris L. Smith, Kaisorn L. Chaichana, Young M. Lee, Benjamin Lin, Kevin M. Stanko, Thomas O'Donnell, Saksham Gupta, Sagar R. Shah, Joanne Wang, Olindi Wijesekera, Michael Delannoy, Andre Levchenko, Alfredo Quinones-Hinojosa
STEM CELLS TRANSLATIONAL MEDICINE
(2015)
Review
Biochemistry & Molecular Biology
Allen K. Kim, Robert DeRose, Tasuku Ueno, Benjamin Lin, Toru Komatsu, Hideki Nakamura, Takanari Inoue
Review
Biochemistry & Molecular Biology
Allen K. Kim, Robert DeRose, Tasuku Ueno, Benjamin Lin, Toru Komatsu, Hideki Nakamura, Takanari Inoue
Review
Biochemistry & Molecular Biology
Benjamin Lin, Andre Levchenko
CURRENT OPINION IN CHEMICAL BIOLOGY
(2012)
Review
Biochemistry & Molecular Biology
Yu-Chun Lin, Siew Cheng Phua, Benjamin Lin, Takanari Inoue
CURRENT OPINION IN CHEMICAL BIOLOGY
(2013)
Article
Cell Biology
Weibo Luo, Benjamin Lin, Yingfei Wang, Jun Zhong, Robert O'Meally, Robert N. Cole, Akhilesh Pandey, Andre Levchenko, Gregg L. Semenza
MOLECULAR BIOLOGY OF THE CELL
(2014)
Article
Biochemistry & Molecular Biology
Yu-Chun Lin, Pawel Niewiadomski, Benjamin Lin, Hideki Nakamura, Siew Cheng Phua, John Jiao, Andre Levchenko, Takafumi Inoue, Rajat Rohatgi, Takanari Inoue
NATURE CHEMICAL BIOLOGY
(2013)
Article
Multidisciplinary Sciences
Benjamin Lin, William R. Holmes, C. Joanne Wang, Tasuku Ueno, Andrew Harwell, Leah Edelstein-Keshet, Takanari Inoue, Andre Levchenko
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2012)
Article
Biochemistry & Molecular Biology
C. Joanne Wang, Adriel Bergmann, Benjamin Lin, Kyuri Kim, Andre Levchenko
Article
Biochemical Research Methods
William R. Holmes, Benjamin Lin, Andre Levchenko, Leah Edelstein-Keshet
PLOS COMPUTATIONAL BIOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Deqing Kong, Zhiyi Lv, Matthias Haering, Benjamin Lin, Fred Wolf, Joerg Grosshans
Article
Multidisciplinary Sciences
B. Lin, J. Luo, R. Lehmann
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Benjamin Lin, Jonathan Luo, Ruth Lehmann
Summary: In this study, the authors developed cell type-specific imaging and perturbation techniques to investigate the migratory behavior of cells in the fruit fly Drosophila. They found that primordial germ cells (PGCs) use retrograde cortical actin flows for guidance during development. They also identified RhoGEF2 as an important regulator of cortical flow and demonstrated the mechanism by which it is regulated.
Review
Biotechnology & Applied Microbiology
Benjamin Lin, Andre Levchenko
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2015)