Review
Medicine, General & Internal
Ping Lai, Jin-Hua Xue, Mu-Jin Xie, Jin-Hua Ye, Ning Yang, Yi-Ming Zhong, Yong-Ling Liao
Summary: This study aimed to compare the effects of high-intensity interval training (HIIT) and moderate-intensity interval training (MIIT) on patients with heart failure with preserved ejection fraction (HFpEF). The results showed that HIIT was beneficial for improving diastolic function in HFpEF patients, but did not significantly improve systolic function and CRF.
Review
Sport Sciences
Eric Tsz-Chun Poon, Waris Wongpipit, Robin Sze-Tak Ho, Stephen Heung-Sang Wong
Summary: This study demonstrated the effectiveness of interval training compared to moderate-intensity continuous training for improving cardiorespiratory fitness in middle-aged and older adults. High-intensity interval training (HIIT) and sprint interval training (SIT) were found to be more effective in increasing VO2max compared to MICT.
JOURNAL OF SPORTS SCIENCES
(2021)
Article
Medicine, General & Internal
Stephan Mueller, Ephraim B. Winzer, Andre Duvinage, Andreas B. Gevaert, Frank Edelmann, Bernhard Haller, Elisabeth Pieske-Kraigher, Paul Beckers, Anna Bobenko, Jennifer Hommel, Caroline M. Van de Heyning, Katrin Esefeld, Pia von Korn, Jeffrey W. Christle, Mark J. Haykowsky, Axel Linke, Ulrik Wisloff, Volker Adams, Burkert Pieske, Emeline M. van Craenenbroeck, Martin Halle
Summary: This study showed that high-intensity interval training and moderate continuous training did not result in significant differences in peak oxygen consumption compared to guideline-based physical activity in patients with heart failure with preserved ejection fraction.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Review
Cardiac & Cardiovascular Systems
Tariq Jamal Siddiqi, Ahmed Mustafa Rashid, Syed Sarmad Javaid, Ahmed Kamal Siddiqi, Muhammad Shariq Usman, Oliver Hervir, Daisuke Kamimura, Carl J. Lavie, Robert J. Mentz, Javed Butler, Michael E. Hall
Summary: High-intensity interval training (HIIT) significantly improved peak oxygen consumption (peak VO2) in patients with HFpEF compared to moderate continuous training (MCT). However, there were no significant changes in left atrial volume index (LAVI), respiratory exchange ratio (RER), and ventilatory efficiency (VE/CO2 slope) between HIIT and MCT in patients with HFpEF.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jan Stassen, See Hooi Ewe, Steele C. Butcher, Mohammed R. Amanullah, Kensuke Hirasawa, Gurpreet K. Singh, Kenny Y. K. Sin, Zee P. Ding, Stephan M. Pio, Ching-Hui Sia, Nicholas W. S. Chew, William K. F. Kong, Kian Keong Poh, David J. Cohen, Philippe Genereux, Martin B. Leon, Nina Ajmone Marsan, Victoria Delgado, Jeroen J. Bax
Summary: The study aimed to investigate the determinants of survival in patients with moderate aortic stenosis (AS) and found that symptom severity and left ventricular ejection fraction (LVEF) were closely related to outcomes. The results showed that patients with more severe symptoms and lower LVEF had higher mortality rates, highlighting the importance of early intervention in these patients.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Jan Stassen, Gurpreet K. Singh, Stephan M. Pio, Suren Chimed, Steele C. Butcher, Kensuke Hirasawa, Nina Ajmone Marsan, Jeroen J. Bax
Summary: This study investigated the prognostic value of LV global longitudinal strain (GLS) in patients with moderate AS and reduced LV systolic dysfunction. The results showed that patients with LVGLS <11% had higher 1-year and 5-year mortality rates compared to patients with LVGLS >= 11%. LVGLS was independently associated with outcomes, while LVEF was not. Therefore, LVGLS has independent prognostic value in patients with moderate AS and reduced LV systolic dysfunction.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Multidisciplinary Sciences
Haohan Yu, Xudong Zhao, Xiaoxia Wu, Jing Yang, Jun Wang, Lijuan Hou
Summary: This systematic review and meta-analysis compared the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on the quality of life (QOL) and mental health (MH) of patients with cardiovascular disease (CVDs). The study found that both HIIT and MICT had similar effects on QOL and MH in CVD patients. However, HIIT showed significant improvements in physical component summary (PCS) for coronary artery disease (CAD) patients and performed better in physical role, vitality, and social function compared to MICT.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Caterina Maffeis, Andrea Rossi, Lorenzo Cannata, Camilla Zocco, Evgeny Belyavskiy, Aravind Kumar Radhakrishnan, Anna Feuerstein, Daniel Armando Morris, Elisabeth Pieske-Kraigher, Burkert Pieske, Frank Edelmann, Pier Luigi Temporelli
Summary: Impaired left atrial function is associated with reduced exercise capacity in patients with chronic heart failure. Left atrial dysfunction can serve as a prognostic marker for poor outcomes in patients with chronic heart failure.
Article
Cardiac & Cardiovascular Systems
Sebastian Rosch, Karl-Patrik Kresoja, Christian Besler, Karl Fengler, Anne Rebecca Schoeber, Maximilian von Roeder, Christian Luecke, Matthias Gutberlet, Karin Klingel, Holger Thiele, Karl-Philipp Rommel, Philipp Lurz
Summary: In this study, patients with heart failure with preserved ejection fraction (HFpEF) were stratified based on left ventricular ejection fraction (LVEF), resulting in distinct morphologic and pathophysiologic subphenotypes. Patients with LVEF ranging from 50% to 60% demonstrated reduced contractility, impaired ventriculo-arterial coupling, and higher extracellular volume fraction, while patients with LVEF >60% exhibited a hypercontractile state with excessive left ventricular afterload and diminished preload reserve.
Article
Cardiac & Cardiovascular Systems
Xinxin Zhang, Yuxi Sun, Yanli Zhang, Feifei Chen, Shuyuan Zhang, Hongyan He, Shuang Song, Gary Tse, Ying Liu
Summary: This study found that HFmrEF patients are heterogeneous with three different subsets identified, each with different outcomes. The association between change in LVEF and adverse outcomes remained significant even after fully adjusting for all-cause mortality and composite outcome. Strategies for managing HFmrEF should include previously measured LVEF to allow stratification based on direction changes in LVEF for better treatment optimization.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Heidi Weberruss, Lisa Baumgartner, Frauke Muehlbauer, Nerejda Shehu, Renate Oberhoffer-Fritz
Summary: This study aimed to assess the structural and functional cardiac adaptations in young competitive athletes in relation to exercise training time, intensity, and performance. The results showed that exercise intensity and maximum aerobic capacity influenced the cardiac adaptations in young athletes, as represented by altered structural parameters but preserved cardiac function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Health Care Sciences & Services
Bin Fang, Yonghwan Kim, Moonyoung Choi
Summary: The study compared the impact of short-term high intensity interval training (HIIT) and traditional moderate intensity continuous training (MICT) on adolescent soccer players, finding that HIIT effectively improved cardiorespiratory fitness and anaerobic power while MICT improved muscle endurance. Both training methods have their own benefits and could be considered in a time-efficient training strategy.
Article
Sport Sciences
Rami Maaloul, Imen Ben Dhia, Houssem Marzougui, Mouna Turki, Faten Hadj Kacem, Rihab Makhlouf, Mohamed Ben Amar, Choumous Kallel, Tarak Driss, Mohamed Habib Elleuch, Fatma Ayadi, Sameh Ghroubi, Omar Hammouda
Summary: This study compared the acute effects of two different intensities of interval training on biochemical and perceptual responses in sedentary adults with obesity. The results showed that high-intensity interval training (HIIT) caused more immune system disruptions and muscle pain, while moderate-intensity interval training (MIIT) was perceived as more tolerable and easier to handle.
Article
Medicine, Research & Experimental
Allyne Baia Leite, Hernando Nascimento Lima, Caleb de Oliveira Flores, Caroline Assuncao Oliveira, Larissa Esterfanne Cavalcante Cunha, Jonas Luz Neves, Thiago Macedo Lopes Correia, Fabricio Freire de Melo, Marcio Vasconcelos Oliveira, Amelia Cristina Mendes de Magalhaes, Telma de Jesus Soares, Liliany Souza de Brito Amaral
Summary: This study compared the effects of preconditioning with high-intensity interval training and continuous training of different intensities on innate immunity markers in female rats with cisplatin-induced acute kidney injury. The results showed that all training protocols promoted renal protection, but high-intensity interval training was more effective in mitigating acute kidney injury induced by cisplatin.
Article
Behavioral Sciences
Chia-Liang Tsai, Chien-Yu Pan, Yu-Ting Tseng, Fu-Chen Chen, Yu-Chuan Chang, Tsai-Chiao Wang
Summary: The study aimed to compare the acute effects of high-intensity interval training (HIIT) and moderate-intensity continuous exercise (MICE) on neurocognitive performance and molecular biomarkers in late middle-aged and older adults. Results showed that both HIIT and MICE improved neurocognitive performance and increased peripheral BDNF levels, but had different effects on neurophysiology and irisin levels. Irisin may play a role in the cognitive performance of working memory in this population, but further research is needed to determine the mechanisms involved.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Matthew Anderson, Clifton Forrest Parrott, Mark J. Haykowsky, Peter H. Brubaker, Fan Ye, Bharathi Upadhya
Summary: Nearly half of heart failure disease burden is attributed to HF with preserved ejection fraction (HFpEF). Patients with HFpEF suffer from severe exercise intolerance, which is associated with skeletal muscle abnormalities such as reduced muscle mass, decreased oxidative muscle fibers, abnormal fat infiltration, and impaired nitric oxide bioavailability. Exercise training and caloric restriction have shown to improve outcomes in HFpEF patients, emphasizing the importance of targeting skeletal muscle to improve exercise intolerance.
HEART FAILURE REVIEWS
(2023)
Article
Cardiac & Cardiovascular Systems
Rhys. L. Beaudry, John. D. Akins, Rauchelle. E. Richey, R. Matthew Brothers, Michael. D. Nelson, Satyam Sarma, Wesley. J. Tucker, Mark. J. Haykowsky
Summary: The purpose of this study was to compare the acute hemodynamic responses during single-leg knee extension exercise between female breast cancer survivors previously treated with anthracycline chemotherapy and age- and sex-matched control subjects. The results showed that leg blood flow was preserved during submaximal exercise in long-term breast cancer survivors, with no significant difference compared to the control group.
JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
(2023)
Article
Nutrition & Dietetics
Rebecca A. G. Christensen, Mark J. Haykowsky, Michelle Nadler, Carla M. Prado, Stephanie D. Small, Julia N. Rickard, Edith Pituskin, D. Ian Paterson, John R. Mackey, Richard B. Thompson, Amy Ashley Kirkham
Summary: Metabolic dysfunction and excess adipose tissue accumulation are harmful side effects of breast cancer treatment. Time-restricted eating (TRE), healthy eating, and reduced sedentary time during chemotherapy may help mitigate these effects. A randomized control trial will be conducted to evaluate the impact of a multimodal intervention, including TRE, on visceral fat accumulation and cardiometabolic dysfunction in breast cancer survivors.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Cardiac & Cardiovascular Systems
Stephen J. Foulkes, Erin J. Howden, Mark J. Haykowsky, Yoland Antill, Agus Salim, Sophie S. Nightingale, Sherene Loi, Piet Claus, Kristel Janssens, Amy M. Mitchell, Leah Wright, Ben T. Costello, Anniina Lindqvist, Lauren Burnham, Imogen Wallace, Robin M. Daly, Steve F. Fraser, Andre La Gerche
Summary: Exercise training for 12 months in breast cancer survivors receiving anthracycline-based chemotherapy can improve cardiorespiratory fitness and prevent cardiac dysfunction, but does not have a lasting effect on functional disability.
Article
Endocrinology & Metabolism
Amy A. Kirkham, Katherine L. Ford, Bruna Ramos Da Silva, Jordan Topolnyski, Carla M. Prado, Anil A. Joy, D. Ian Paterson, Normand Boule, Edith Pituskin, Mark J. Haykowsky, Richard B. Thompson
Summary: This study evaluated the feasibility and preliminary efficacy of telephone-based delivery of weekday-only time-restricted eating. The results showed that telephone-delivered weekday TRE was a feasible, acceptable, low-symptom, and low-cost intervention. However, despite clinically relevant changes occurring within individual participants, there were no significant changes in overall metabolic syndrome, lipid profile, or hemoglobin A(1c) and no changes in hepatic steatosis and thigh myosteatosis. Dietary intake changes included reduced energy and protein, while physical activity and sleep did not change.
Article
Physiology
Kanokwan Bunsawat, Heather L. Clifton, Stephen M. Ratchford, Jennifer R. Vranish, Jeremy K. Alpenglow, Mark J. Haykowsky, Joel D. Trinity, John J. Ryan, Paul J. Fadel, D. Walter Wray
Summary: The study found that patients with HFpEF have a reduced pressor response to static muscle contractions compared to healthy controls, which may be partly due to a blunted muscle metaboreflex. These findings indicate a disease-related dysregulation in neural cardiovascular control during exercise in patients with HFpEF.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Neurosciences
Andrew P. Oneglia, Lidia S. Szczepaniak, Manall F. Jaffery, Daisha J. Cipher, Jeffrey G. McDonald, Mark J. Haykowsky, Kerrie L. Moreau, Deborah J. Clegg, Vlad Zaha, Michael D. Nelson
Summary: Mounting evidence suggests that myocardial steatosis contributes to left ventricular diastolic dysfunction. However, there is a lack of definitive evidence in humans due to confounding comorbidities. Therefore, a 48-hour food restriction model was used to acutely increase myocardial triglyceride content in 27 young healthy volunteers. The results showed that myocardial steatosis impairs diastolic-systolic coupling and may contribute to the progression of heart disease.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Oncology
Bruna Ramos Da Silva, Amy A. Kirkham, Katherine L. Ford, Mark J. Haykowsky, D. Ian Paterson, Anil A. Joy, Edith Pituskin, Richard Thompson, Carla M. Prado
Summary: This study investigated the effects of weekday time-restricted eating (TRE) on body composition. The results showed that TRE led to a decrease in body weight and total fat mass, and had a positive impact on body composition in individuals with obesity.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Gordon McGregor, Richard Powell, Brian Begg, Stefan T. Birkett, Simon Nichols, Stuart Ennis, Scott McGuire, Jonathon Prosser, Olivier Fiassam, Siew Wan Hee, Thomas Hamborg, Prithwish Banerjee, Ned Hartfiel, Joanna M. Charles, Rhiannon T. Edwards, Aimee Drane, Danish Ali, Faizel Osman, Hejie He, Tom Lachlan, Mark J. Haykowsky, Lee Ingle, Rob Shave
Summary: This study aims to assess the clinical effectiveness and safety of low-volume high-intensity interval training (HIIT) compared with moderate-intensity steady-state (MISS) exercise training in patients with coronary artery disease. The results showed that low-volume HIIT improved cardiorespiratory fitness more than MISS and had a higher safety profile. Therefore, low-volume HIIT can be considered as an important adjunct or alternative to MISS in cardiac rehabilitation programs.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Andreas B. Gevaert, Birgit Boehm, Haley Hartmann, Inge Goovaerts, Tibor Stoop, Caroline M. Van De Heyning, Paul J. Beckers, Flavia Baldassarri, Stephan Mueller, Renate Oberhoffer, Andre Duvinage, Mark J. Haykowsky, Ulrik Wisloff, Volker Adams, Burkert Pieske, Martin Halle, Emeline M. Van Craenenbroeck
Summary: This study investigated the effects of MICT and HIIT on vascular function and repair in HFpEF. The results showed that these training methods did not change vascular function or cellular endothelial repair. This did not significantly contribute to the improvement of VO2peak in HFpEF patients.
JACC-HEART FAILURE
(2023)
Correction
Medicine, General & Internal
Tamara L. Dorfman, Mandy Archibald, Mark Haykowsky, Shannon D. Scott
SYSTEMATIC REVIEWS
(2023)
Review
Medicine, General & Internal
Tamara L. Dorfman, Mandy Archibald, Mark Haykowsky, Shannon D. Scott
Summary: This article mainly introduces the psychosocial consequences of congenital heart disease (CHD) for children and adolescents living with CHD and their primary caregivers. Children and adolescents with CHD undergo multiple traumatizing invasive surgical and medical procedures, face disabilities resulting from CHD, unfair scrutiny, marginalization, and are at risk for mental health issues. Primary caregivers of children and adolescents with CHD also experience increased stress, fear, anxiety, depression, and financial burden. The objective of this scoping review is to determine the current state of knowledge on negative psychosocial consequences and inform research aimed at developing interventions to decrease these consequences.
SYSTEMATIC REVIEWS
(2023)
Article
Nutrition & Dietetics
Bruna Ramos Da Silva, Amy A. Kirkham, Katherine L. Ford, Mark J. Haykowsky, D. Ian Paterson, Anil A. Joy, Edith Pituskin, Richard Thompson, Carla M. Prado
Summary: The aim of this study was to evaluate the association between phase angle (PhA) obtained from bioelectrical impedance analysis (BIA) and health-related physical fitness (including cardiorespiratory fitness, skeletal muscle volume, and myosteatosis) among older breast cancer survivors. The results showed that higher values of PhA were associated with better health-related physical fitness among this population.
CLINICAL NUTRITION ESPEN
(2023)
Letter
Cardiac & Cardiovascular Systems
Sauyeh K. Zamani, Satyam Sarma, James P. Macnamara, Linda S. Hynan, Mark J. Haykowsky, Christopher M. Hearon, Denis Wakeham, Tiffany Brazile, Benjamin D. Levine, Vlad G. Zaha, Michael D. Nelson
Meeting Abstract
Cardiac & Cardiovascular Systems
Kai Yi Wu, Amy Kirkham, James A. White, Mark J. Haykowsky, Jason Dyck, Justin A. Ezekowitz, Gavin Oudit, Joseph Kurian, Richard Thompson, Edith Pituskin, Ian Paterson
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
