Review
Pharmacology & Pharmacy
Mohammad Azam Ansari, Farheen Badrealam Khan, Haaris Ahsan Safdari, Ahmad Almatroudi, Mohammad A. Alzohairy, Mohammadreza Safdari, Mehran Amirizadeh, Suriya Rehman, Mohammad Javed Equbal, Mehboob Hoque
Summary: The review collates the pharmacological properties of Tanshinone IIA (Tan IIA) with a special emphasis on its therapeutic potential against diverse diseases, while also discussing possible applications of various therapeutic formulations based on nanotechnology. The convergence of nanomedicine and the therapeutic potential of Tan IIA shows great promise in clinical application.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Federico De Leonardis, Gaia Colalillo, Enrico Finazzi Agro, Roberto Miano, Andrea Fuschi, Anastasios D. Asimakopoulos
Summary: Erectile dysfunction is a common condition, mainly caused by vascular factors and endothelial dysfunction, which has a close connection with cardiovascular disease. Early detection of ED can help prevent cardiovascular risks. Therefore, patients presenting with ED should undergo cardiac assessment and treatment.
Review
Biochemistry & Molecular Biology
Teresa Salvatore, Raffaele Galiero, Alfredo Caturano, Luca Rinaldi, Anna Di Martino, Gaetana Albanese, Jessica Di Salvo, Raffaella Epifani, Raffaele Marfella, Giovanni Docimo, Miriam Lettieri, Celestino Sardu, Ferdinando Carlo Sasso
Summary: SGLT2 inhibitors play a critical role in glycemic regulation in diabetes and also prevent damage to the heart and kidneys. In addition to their target effects, SGLT2 inhibitors have beneficial actions on various pathways, including improving cardiac metabolism and regulating load conditions in the heart and kidneys.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Marianne Uhre Jakobsen, Anette Bysted, Heddie Mejborn, Anders Stockmarr, Ellen Trolle
Summary: This study conducted an overview of systematic reviews on the intake of unprocessed and processed meat in relation to cardiovascular disease, finding that unprocessed red meat is moderately associated with stroke and processed meat is moderately associated with CHD and stroke. Overall confidence in the results was rated as critically low.
Review
Biochemistry & Molecular Biology
Parveen Abdul Rahim, Devika Rengaswamy
Summary: Cardiovascular diseases are the leading cause of death worldwide, and current treatments have limitations. Fibrinolytic enzymes derived from various sources are being studied for their therapeutic potential in treating these diseases. This review provides an overview of the mechanisms, sources, and therapeutic potential of fibrinolytic enzymes.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Stanley T. Crooke, Brenda F. Baker, Rosanne M. Crooke, Xue-hai Liang
Summary: Antisense technology is delivering on its promise to treat diseases by targeting RNA, with nine single-stranded ASO drugs approved for commercial use. In addition to rare diseases, ASOs in development are intended to treat common diseases and show potential for increased potency and performance.
NATURE REVIEWS DRUG DISCOVERY
(2021)
Review
Medicine, Research & Experimental
Anamika Gupta, Hezlin Marzook, Firdos Ahmad
Summary: The novel coronavirus SARS-CoV-2 causes major challenges to the healthcare system, with millions of deaths worldwide and a high mortality rate associated with pre-existing clinical conditions. The presence of cardiometabolic diseases and certain medical factors are strongly linked to poor outcomes in COVID-19 patients, leading to severe complications and death.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Environmental Sciences
Noushin Zahedi, Samaneh Pourajam, Erfan Zaker, Shirin Kouhpayeh, Seyedeh Mahnaz Mirbod, Mehrsa Tavangar, Mohsen Boshtam, Kaveh Hatami Kahkesh, Qiuping Qian, Feng Zhang, Laleh Shariati, Hossein Khanahmad, Maryam Boshtam
Summary: Cardiovascular diseases are major concerns worldwide and can be influenced by the environment. Natural compounds, such as trehalose, offer a promising alternative for CVD treatment due to their ability to regulate molecular pathways with minimal adverse effects. Trehalose has cardio-protective properties through its induction of autophagy, mediated by TFEB and FOXO1 transcription factors.
ENVIRONMENTAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Karen Julissa Loaeza-Reyes, Edgar Zenteno, Adriana Moreno-Rodriguez, Rafael Torres-Rosas, Liliana Argueta-Figueroa, Roberta Salinas-Marin, Lizet Monserrat Castillo-Real, Socorro Pina-Canseco, Yobana Perez Cervera
Summary: The cardiovascular system relies on glycosylation for various functions, involving N-glycosylation, O-glycosylation, and O-GlcNAcylation. These modifications play crucial roles in signal reception, transduction, and cellular response to external stimuli in different conditions such as physiological states, ischemia/reperfusion, exercise, and low-grade inflammation in diabetes and aging. Mutations in glycosyltransferases and receptors have been linked to cardiovascular diseases, suggesting that understanding glycosylation and its effects may provide potential therapeutic interventions.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Clinical Neurology
Q. Lisan, P. Marques-Vidal, N. Hausler, N. Danchin, P. Boutouyrie, A. Asselin, X. Jouven, R. Heinzer, J. P. Empana
Summary: This study aimed to compare the patterns of microRNAs expression between OSA and control patients with and without incident CVD. The results showed that there was no association between a large panel of microRNAs and OSA patients with and without incident CVD.
Review
Geriatrics & Gerontology
Christina Pagiatakis, Elettra Musolino, Rosalba Gornati, Giovanni Bernardini, Roberto Papait
Summary: The review discusses the critical role of aging in diseases such as cancer and cardiovascular diseases, as well as the mechanisms of epigenetics in these diseases, emphasizing the close relationship between changes in gene expression and cellular alterations during the aging process.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Review
Chemistry, Analytical
Fakhara Sabir, Mahmood Barani, Mahwash Mukhtar, Abbas Rahdar, Magali Cucchiarini, Muhammad Nadeem Zafar, Tapan Behl, Simona Bungau
Summary: Cardiovascular diseases are a leading cause of death worldwide, and there is a need for more effective early diagnosis methods. Nanomaterial systems are recognized as potential candidates to enhance diagnostic instrument functionality, with their unique properties effectively targeting cardiovascular diseases.
Article
Clinical Neurology
Andras Bikov, Sebastien Bailly, Dries Testelmans, Francesco Fanfulla, Athanasia Pataka, Izolde Bouloukaki, Holger Hein, Zoran K. Dogas, Ozen Basoglu, Richard Staats, Gianfranco Parati, Carolina Lombardi, Ludger Grote, Stefan Mihaicuta, ESADA Study Grp
Summary: Periodic limb movements during sleep may be an additional risk factor for cardiovascular disease in patients with obstructive sleep apnea, as it is associated with dyslipidemia. This study aimed to determine the impact of periodic limb movements during sleep on serum lipid levels in obstructive sleep apnea patients.
JOURNAL OF SLEEP RESEARCH
(2023)
Review
Medicine, Research & Experimental
Lucas Zangerolamo, Jean F. Vettorazzi, Lucas R. O. Rosa, Everardo M. Carneiro, Helena C. L. Barbosa
Summary: TUDCA, a bile acid found in bear bile, has been shown to have neuroprotective effects in various neurodegenerative disorders like Alzheimer's disease, Parkinson's disease, and Huntington's disease by inhibiting apoptosis, attenuating oxidative stress, and reducing endoplasmic reticulum stress in experimental models. This research expands the understanding of TUDCA's actions in ND and provides novel perspectives and opportunities for the treatment of these diseases.
Review
Biochemistry & Molecular Biology
Kohsuke Shirakawa, Motoaki Sano
Summary: Recent advances in pharmacotherapy have improved the prognosis of cardiovascular disease, but there is still residual risk. Inflammation is a potential target for treating this residual risk. Neutrophil-induced inflammation plays a key role in the pathogenesis of cardiovascular disease, and neutrophils exhibit diversity due to circadian rhythm-related and disease-specific microenvironment changes.
