Review
Cardiac & Cardiovascular Systems
Aish Sinha, Haseeb Rahman, Andrew Webb, Ajay M. Shah, Divaka Perera
Summary: CMD, characterized by impaired coronary flow reserve (CFR), plays a central role in the pathogenesis of HFpEF, involving subendocardial ischemia and impaired lusitropy. Future prospective follow-up studies are essential for a better understanding of these diseases and may lead to the development of tailored therapies to improve quality of life and prognosis in patients with CMD and HFpEF.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Rikuta Hamaya, Taishi Yonetsu, Kodai Sayama, Kazuki Matsuda, Hiroki Ueno, Tatsuhiro Nagamine, Toru Misawa, Masahiro Hada, Masahiro Hoshino, Tomoyo Sugiyama, Tetsuo Sasano, Tsunekazu Kakuta
Summary: This study investigated the determinants and prognostic implications of changes in coronary flow capacity (CFC) following percutaneous coronary intervention (PCI) in patients with chronic coronary syndrome (CCS). The results showed that changes in CFC were associated with the risk of incident target vessel failure (TVF) and were largely predicted by the pre-PCI CFC status.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Gabor Tamas Szabo, Aron Uveges, Balazs Tar, Andras Agoston, Azzaya Dorj, Csaba Jenei, Rudolf Kolozsvari, Benjamin Csippa, Daniel Czuriga, Zsolt Koszegi
Summary: A new evaluation method based on flow measurement can better guide treatment decisions for atherosclerotic coronary heart disease, with the flow separation index (FSi) showing correlation with the degree of stenosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Annagrazia Cecere, Peter L. M. Kerkhof, Giovanni Civieri, Annalisa Angelini, Antonio Gambino, Angela Fraiese, Tomaso Bottio, Elena Osto, Giulia Famoso, Marny Fedrigo, Enrico Giacomin, Giuseppe Toscano, Roberta Montisci, Sabino Iliceto, Gino Gerosa, Francesco Tona
Summary: Coronary microvascular dysfunction after heart transplantation can be classified into four endotypes, with one type showing higher mortality rate over a 28-year follow-up period. Independent predictors of mortality include CMD, DPVh < 75 cm/s and CCFVR < 80 cm/s.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Damien Collison, Matthaios Didagelos, Muhammad Aetesam-Ur-Rahman, Samuel Copt, Robert McDade, Peter McCartney, Thomas J. Ford, John McClure, Mitchell Lindsay, Aadil Shaukat, Paul Rocchiccioli, Richard Brogan, Stuart Watkins, Margaret McEntegart, Richard Good, Keith Robertson, Patrick O'Boyle, Andrew Davie, Adnan Khan, Stuart Hood, Hany Eteiba, Colin Berry, Keith G. Oldroyd
Summary: The TARGET-FFR trial examined the importance of FFR value >= 0.90 after PCI, finding that an FFR-guided optimization strategy did not significantly increase this proportion, but did reduce the proportion of patients with FFR value <= 0.80.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Damien Collison, Matthaios Didagelos, Muhammad Aetesam-ur-Rahman, Samuel Copt, Robert McDade, Peter McCartney, Thomas J. Ford, John McClure, Mitchell Lindsay, Aadil Shaukat, Paul Rocchiccioli, Richard Brogan, Stuart Watkins, Margaret McEntegart, Richard Good, Keith Robertson, Patrick O'Boyle, Andrew Davie, Adnan Khan, Stuart Hood, Hany Eteiba, Colin Berry, Keith G. Oldroyd
Summary: The study aimed to evaluate the feasibility and efficacy of a post-PCI FFR-guided optimization strategy compared to standard coronary angiography in achieving final post-PCI FFR values >= 0.90. While the FFR-guided optimization strategy did not significantly increase the proportion of patients with final FFR >= 0.90, it did significantly reduce the proportion of patients with final FFR <= 0.80.
EUROPEAN HEART JOURNAL
(2021)
Article
Multidisciplinary Sciences
Stefanos Drakos, Grigorios Chatzantonis, Michael Bietenbeck, Georg Evers, Arik Bernard Schulze, Michael Mohr, Helena Fonfara, Claudia Meier, Ali Yilmaz
Summary: COVID-19 patients may experience coronary microvascular disease, resulting in persistent symptoms of exercise dyspnea and fatigue.
SCIENTIFIC REPORTS
(2021)
Review
Cardiac & Cardiovascular Systems
Tingting Liu, Mingyan Ding, Dandan Sun, Huihui Zhang, Lijuan Guo, Ying Li, Hanzhang Zhao, Fang Zhu
Summary: This study explored the correlation between heart rate reserve (HRR) and coronary flow velocity reserve (CFVR) in ANOCA patients. It was found that reduced HRR was associated with impaired CFVR, especially in females. A multivariate logistic regression identified HRR as the strongest predictor of impaired CFVR in women, with HRR < 35% being a strong indicator of impaired CFVR in females.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Bernard De Bruyne, Nico H. J. Pijls, Emanuele Gallinoro, Alessandro Candreva, Stephane Fournier, Danielle C. J. Keulards, Jeroen Sonck, Marcel Van't Veer, Emanuele Barbato, Jozef Bartunek, Marc Vanderheyden, Eric Wyffels, Annemiek De Vos, Mohamed El Farissi, Pim A. L. Tonino, Olivier Muller, Carlos Collet, William F. Fearon
Summary: This study proposes microvascular resistance reserve (MRR) as a specific index for assessing coronary microvascular function, independent of autoregulation and myocardial mass, based on absolute values of coronary flow and pressure. The research found a strong correlation between continuous thermodilution-derived MRR and Doppler MRR, suggesting MRR as a specific, quantitative, and operator-independent metric for quantifying coronary microvascular dysfunction.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Review
Medicine, General & Internal
Monica Verdoia, Andrea Rognoni
Summary: Recent evidence shows that ischemia, rather than coronary artery disease, is a major determinant of outcomes in ischemic heart disease. Guidelines recommend using functional criteria, rather than anatomical findings, to guide myocardial revascularization strategies. The assessment of coronary physiology, including fractional flow reserve (FFR) and instant-wave free ratio (iFR), is becoming increasingly important, but there are still debates over the best strategy due to technical and clinical conditions that may bias the evaluation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Ashkan Eftekhari, Tim P. van de Hoef, Masahiro Hoshino, Joo Myung Lee, Coen K. M. Boerhout, Guus A. de Waard, Ji-Hyun Jung, Seung Hun Lee, Hernan Mejia-Renteria, Mauro Echavarria-Pinto, Martijn Meuwissen, Hitoshi Matsuo, Maribel Madera-Cambero, Mohamed A. Effat, Koen Marques, Joon-Hyung Doh, Rupak Banerjee, Chang-Wook Nam, Giampaolo Niccoli, Tadashi Murai, Masafumi Nakayama, Nobuhiro Tanaka, Eun-Seok Shin, Paul Knaapen, Niels van Royen, Javier Escaned, Bon Kwon Koo, Steven A. J. Chamuleau, Tsunekazu Kakuta, Jan J. Piek, Evald Hoj Christiansen
Summary: This study investigated the association between changes in microvascular resistance (MR) and target vessel failure (TVF) in patients undergoing percutaneous coronary intervention (PCI). The results showed that increased MR post-PCI was associated with lesions of less severe hemodynamic influence at baseline and higher rates of TVF at follow-up.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Juwon Kim, Doosup Shin, Joo Myung Lee, Seung Hun Lee, David Hong, Ki Hong Choi, Doyeon Hwang, Coen K. M. Boerhout, Guus A. de Waard, Ji-Hyun Jung, Hernan Mejia-Renteria, Masahiro Hoshino, Mauro Echavarria-Pinto, Martijn Meuwissen, Hitoshi Matsuo, Maribel Madera-Cambero, Ashkan Eftekhari, Mohamed A. Effat, Tadashi Murai, Koen Marques, Joon-Hyung Doh, Evald H. Christiansen, Rupak Banerjee, Hyun Kuk Kim, Chang-Wook Nam, Giampaolo Niccoli, Masafumi Nakayama, Nobuhiro Tanaka, Eun-Seok Shin, Steven A. J. Chamuleau, Niels van Royen, Paul Knaapen, Bon Kwon Koo, Tsunekazu Kakuta, Javier Escaned, Jan J. Piek, Tim P. van de Hoef
Summary: This study aimed to evaluate the comparative prognosis of patients with intermediate FFR based on their CFR values and whether PCI should be deferred or performed. The results showed that PCI was associated with a lower risk of TVF when CFR was depressed, but there was no difference when CFR was preserved.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Nils P. Johnson, Hitoshi Matsuo, Masafumi Nakayama, Ashkan Eftekhari, Tsunekazu Kakuta, Nobuhiro Tanaka, Evald H. Christiansen, Richard L. Kirkeeide, K. Lance Gould
Summary: This study aimed to assess clinical outcomes after combined pressure and flow assessment of coronary lesions. Results showed discrepancies between FFR and CFR, with certain lesions experiencing higher event rates during the 2-year follow-up.
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Medicine, General & Internal
Clarissa Borguezan Daros, Quirino Ciampi, Lauro Cortigiani, Nicola Gaibazzi, Fausto Rigo, Karina Wierzbowska-Drabik, Jaroslaw D. Kasprzak, Claudio Dodi, Bruno Villari, Francesco Antonini-Canterin, Valentina Lorenzoni, Michele De Nes, Clara Carpeggiani, Eugenio Picano
Summary: In patients with non-ischemic heart failure, abnormal left ventricular contractile reserve (LVCR), coronary flow velocity reserve (CFVR), and heart rate reserve (HRR) are frequently observed during dipyridamole stress echocardiography (DSE) and are useful for outcome prediction, targeting different pathophysiological vulnerabilities.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Tim P. van de Hoef, Joo Myung Lee, Coen K. M. Boerhout, Guus A. de Waard, Ji-Hyun Jung, Seung Hun Lee, Hernan Mejia-Renteria, Masahiro Hoshino, Mauro Echavarria-Pinto, Martijn Meuwissen, Hitoshi Matsuo, Maribel Madera-Cambero, Ashkan Eftekhari, Mohamed A. Effat, Tadashi Murai, Koen Marques, Joon-Hyung Doh, Evald H. Christiansen, Rupak Banerjee, Chang-Wook Nam, Giampaolo Niccoli, Masafumi Nakayama, Nobuhiro Tanaka, Eun-Seok Shin, Niels van Royen, Steven A. J. Chamuleau, Paul Knaapen, Javier Escaned, Tsunekazu Kakuta, Bon Kwon Koo, Jan J. Piek
Summary: This study demonstrated the clinical implications of combined assessment of fractional flow reserve (FFR) and coronary flow reserve (CFR) in chronic coronary syndromes, showing that impaired coronary hemodynamics are uniformly associated with increased 5-year target vessel event rates.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)