Article
Biochemistry & Molecular Biology
Pablo Cruz, Ulises Ahumada-Castro, Galdo Bustos, Jordi Molgo, Daniela Sauma, Alenka Lovy, Cesar Cardenas
Summary: T-cell acute lymphoblastic leukemia is an aggressive hematological malignancy characterized by high mitochondrial respiration levels. Inhibiting InsP3R can lead to T-ALL cell death without affecting normal cells, potentially serving as an alternative therapeutic approach for T-ALL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Serhii Chornyi, Claudio F. Costa, Lodewijk IJlst, Marc Fransen, Ronald J. A. Wanders, Carlo W. T. van Roermund, Hans R. Waterham
Summary: This study developed a method to measure intraperoxisomal NADH levels in human cells and found that the NAD+/NADH ratio in cytosol and peroxisomes are closely connected, mediated by intraperoxisomal lactate and malate dehydrogenases. This study provides evidence for the existence of two independent redox shuttle systems in human peroxisomes that regulate peroxisomal NAD+/NADH homeostasis. It also demonstrates the specific metabolic function of protein isoforms generated by translational stop codon readthrough in humans.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cell Biology
James Kealey, Heiko Dussmann, Irene Llorente-Folch, Natalia Niewidok, Manuela Salvucci, Jochen H. M. Prehn, Beatrice D'Orsi
Summary: The study reveals that activating KRAS mutations and loss of TP53 remodel cancer metabolism and lead to alterations in bioenergetics under metabolic stress conditions by modulating cellular ATP production, NADH oxidation, mitochondrial respiration and function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shivani Nanda, Marc-Antoine Jacques, Wen Wang, Chad L. Myers, L. Safak Yilmaz, Albertha J. M. Walhout
Summary: A new study reveals that three-quarters of metabolic genes in the nematode Caenorhabditis elegans are transcriptionally regulated, and generates a co-regulated subpathway map of metabolism. The researchers also develop a web application to query gene associations with metabolic pathways. This study sheds light on the ubiquity of transcriptional regulation in metabolism and provides a blueprint for similar studies in other organisms.
MOLECULAR SYSTEMS BIOLOGY
(2023)
Editorial Material
Multidisciplinary Sciences
Pingzhu Zhou, William T. Pu
Summary: A fatty acid in the milk of nursing mice initiates a metabolic shift in newborn heart muscle cells, promoting their rapid maturation.
Article
Cell Biology
GuoYan Wang, SenLin Qin, Lei Chen, HuiJun Geng, YiNing Zheng, Chao Xia, JunHu Yao, Lu Deng
Summary: This study found that sodium butyrate (NaB) enhances RSL3- and erastin-induced cell ferroptosis by downregulating the expression of SLC7A11 and GPX4, leading to lipid ROS production. The FFAR2-AKT-NRF2 and FFAR2-mTORC1 axes mediate the downregulation of SLC7A11 and GPX4 by NaB in a cAMP-PKA-dependent manner. Functionally, NaB inhibits tumor growth and this effect can be reversed by the mTORC1 activator MHY1485 and the ferroptosis inhibitor Ferr-1. Overall, NaB treatment can induce mTOR-dependent ferroptosis and suppress tumor growth, suggesting its potential clinical applications for colorectal cancer treatment.
CELL DEATH & DISEASE
(2023)
Article
Neurosciences
Mei Makino, Enkhjin Ulzii, Riku Shirasaki, Jeongho Kim, Young-Jai You
Summary: Sleep and metabolism are interconnected homeostatic states, with diet regulating the sleep cycle. Specific combinations of neuropeptides released in Caenorhabditis elegans play a role in controlling satiety quiescence, allowing animals to gauge their metabolic state and induce a feeding-induced sleep-like state.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Physiology
Gayathri K. Natarajan, Jyotsna Mishra, Amadou K. S. Camara, Wai-Meng Kwok
Summary: Despite being discovered nearly two decades ago, the exact function and mechanism of LETM1 protein in the inner mitochondrial membrane remain unresolved. However, LETM1 has been associated with regulating fundamental cellular processes such as development, cellular respiration, metabolism, and apoptosis.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Elizabeth S. Li, Margaret S. Saha
Summary: Novel methods for calcium ion detection have diverse applications in vitro and in vivo, especially when matched with advances in fluorescence imaging techniques. The limitations presented by organic calcium dyes, genetically encoded calcium indicators, and calcium-responsive nanoparticles suggest a potential path for more rapid optimization using a synthetic biology approach. This engineering-oriented discipline can offer a promising toolkit for interfacing with calcium signaling in eukaryotic systems.
Review
Biochemistry & Molecular Biology
Nikita Arnst, Nelly Redolfi, Annamaria Lia, Martina Bedetta, Elisa Greotti, Paola Pizzo
Summary: Alzheimer's disease is a neurodegenerative illness characterized by the loss of neurons in specific brain areas. The calcium hypothesis is at the forefront of current research as a potential key pathway in Alzheimer's disease.
Article
Neurosciences
Abel Eraso-Pichot, Sandrine Pouvreau, Alexandre Olivera-Pinto, Paula Gomez-Sotres, Urszula Skupio, Giovanni Marsicano
Summary: The study of astrocytic contribution to brain functions has gained popularity in neuroscience. Recent discoveries have shown the involvement of astrocytes in synaptic functions and revealed their previously unimaginable multiple functions. Additionally, research on cannabinoids has identified different ways they interact with astrocytes, modify their functions, alter their communication with neurons, and impact behavior. This review discusses the expression of endocannabinoid system members in astrocytes and the latest findings on cannabinoid modulation of important astroglial functions, such as calcium dynamics, gliotransmission, metabolism, and inflammation.
Review
Multidisciplinary Sciences
Hehe He, Youran Li, Liang Zhang, Zhongyang Ding, Guiyang Shi
Summary: This article aims to provide a systematic introduction to nitrogen metabolism in Bacillus, an important industrial microorganism, and apply its regulatory logic to synthetic biology to improve biosynthesis competitiveness. Understanding the meticulous regulation process of nitrogen metabolism not only facilitates metabolic engineering research but also provides constructive insights and inspiration for studies of other microorganisms.
JOURNAL OF ADVANCED RESEARCH
(2023)
Review
Cell Biology
Bhagwati Joshi, Jagdish Chandra Joshi, Dolly Mehta
Summary: This review summarizes the regulatory mechanisms of cGAS activity, including structure, sub-cellular localization, post-translational modifications, and Ca2+ signaling. The role of cGAS activation in different diseases and clinical outcomes is also discussed.
Review
Cardiac & Cardiovascular Systems
Chrishan J. A. Ramachandra, Jasper Chua, Shuo Cong, Myu Mai Ja Kp, Winston Shim, Joseph C. Wu, Derek J. Hausenloy
Summary: Normal cardiac functions depend on continuous energy supply. Metabolic disturbances and impaired mitochondrial bioenergetics underlie various cardiac diseases, but specific treatments are lacking. Patient-derived iPSCs show promise for studying cardiomyopathies and novel therapies.
CARDIOVASCULAR RESEARCH
(2021)
Review
Cell Biology
Qiu Xue, Ru Yan, Shengtao Ji, Shu Yu
Summary: O-GlcNAcylation is an important post-translational modification that rapidly modulates protein activity and is involved in multiple metabolic pathways. Its regulatory role in mitochondrial function is crucial for maintaining mitochondrial homeostasis, and dysregulation can lead to various mitochondrial dysfunctions.