Article
Pharmacology & Pharmacy
Hyemin Lee, Duen-Yi Huang, Hua-Ching Chang, Chia-Yee Lin, Wan-Yu Ren, Yang-Shia Dai, Wan-Wan Lin
Summary: B lymphocyte-induced maturation protein-1 (Blimp-1) can be transcriptionally upregulated by various stimuli in keratinocytes and squamous cell carcinoma (SCC) via EGFR transactivation and the AP-1 pathway. The nuclear localization of Blimp-1 remains unchanged under stimulation, and silencing Blimp-1 can enhance SCC cell migration. These findings suggest a potential therapeutic target in SCC by targeting Blimp-1 as a negative regulator of cell migration.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Khoa A. Nguyen, Madison J. Keith, Stephen B. Keysar, Spencer C. Hall, Anamol Bimali, Antonio Jimeno, Xiao-Jing Wang, Christian D. Young
Summary: Preneoplastic keratinocytes can directly promote the growth and drug resistance of head and neck squamous cell carcinoma (HNSCC) by activating EGFR. Ligands released by preneoplastic keratinocytes activate EGFR and FGFR, and inhibition of EGFR can weaken the drug resistance and CSC phenotypes induced by preneoplastic keratinocytes. Additionally, the tumor microenvironment plays an important role in the sensitivity of PI3K inhibitors and the maintenance of CSCs.
MOLECULAR CARCINOGENESIS
(2022)
Article
Oncology
Hechen Wang, Tianyu Wang, Zeying Zhang, Yu Fan, Lan Zhang, Kuan Gao, Shuya Luo, Qinghuan Xiao, Changfu Sun
Summary: High TMEM16A expression is associated with large tumor size, lymph node metastasis, and poor clinical outcome in patients with OSCC. TMEM16A overexpression promotes cell proliferation, while inhibition of TMEM16A channel activities suppresses cell proliferation in OSCC cells. Simvastatin suppresses TMEM16A channel activities and inhibits cell proliferation in OSCC cells through TMEM16A, providing a novel anti-tumor mechanism.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Dan Yang, Dan Yang, Yuqing He, Jiaxin Liu, Yansong Song, Yu Zhou, Lu Jiang, Xin Zeng, Xiaoping Xu, Hao Xu, Jing Li, Hongxia Dan
Summary: The overexpression of MRTF-A/SRF was found to inhibit the proliferation, migration, and invasion of oral squamous cell carcinoma (OSCC) cells in vitro. High expression of SRF and its co-activator MRTF-A was associated with better prognosis in OSCC patients on the hard palate, alveolar ridge, and oral tongue. It was also observed that overexpression of MRTF-A/SRF inhibited the epithelial-mesenchymal transformation (EMT) of OSCC cells.
Review
Medicine, General & Internal
Ashley Wysong
Summary: Squamous-cell carcinoma is a common type of cancer in humans, with most cases being localized and treatable, but a small percentage of cases that recur or spread can be fatal. Immunocompromised patients are at particularly high risk.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Oncology
Yuxi Cheng, Juan Chen, Yuxin Shi, Xiaodan Fang, Zhangui Tang
Summary: The aim of this review is to summarize our studies on the signaling pathways involved in the development of oral cancer and several molecular targeting technologies combined with immune checkpoint therapies to provide new therapeutic strategies for oral squamous cell carcinoma. Oral squamous cell carcinoma accounts for 95% of human head and neck squamous cell carcinoma cases and has a poor prognosis. The mitogen-activated protein kinase (MAPK) signaling pathway is activated in over 50% of human oral cancer cases. We review the research progress on the MAPK signaling pathway and discuss its potential as a therapeutic strategy for oral squamous cell carcinoma.
Review
Cell Biology
Joshua H. Choe, Simbarashe Mazambani, Tae Hoon Kim, Jung-whan Kim
Summary: Squamous cell carcinomas (SCCs) are common solid tumors that have not fully benefited from recent advances in molecularly targeted therapy or immunotherapy. A lack of a consolidated perspective on genetic aberrations and essential factors for SCC pathogenesis, as well as cellular heterogeneity in SCC, has contributed to a critical dearth in effective and specific therapies. Emerging evidence characterizing the distinct genomic, epigenetic, and metabolic landscapes of SCC may reveal targetable vulnerabilities at their intersection.
Article
Oncology
Osamu Maehara, Goki Suda, Mitsuteru Natsuizaka, Taku Shigesawa, Gouki Kanbe, Megumi Kimura, Masaya Sugiyama, Masashi Mizokami, Masato Nakai, Takuya Sho, Kenichi Morikawa, Koji Ogawa, Shinya Ohashi, Shingo Kagawa, Hideaki Kinugasa, Seiji Naganuma, Naoto Okubo, Shunsuke Ohnishi, Hiroshi Takeda, Naoya Sakamoto
Summary: Fibroblast growth factors (FGFs) and their receptors (FGFRs) play an important role in maintaining cancer stem-like cells in esophageal squamous cell carcinoma (ESCC). This study reveals that FGFR2, particularly the IIIb isoform, is highly expressed in non-CSCs, inducing keratinocyte differentiation and decreasing CSC populations. Analysis using The Cancer Genome Atlas (TCGA) dataset shows a significant correlation between FGFR2 expression and cancer cell differentiation in ESCC clinical samples, suggesting FGFR2-AKT signaling as a potential therapeutic target for ESCC.
CANCER BIOLOGY & THERAPY
(2021)
Article
Health Care Sciences & Services
Shyng-Shiou F. Yuan, Amos C. Hung, Ching-Wei Hsu, Ting-Hsun Lan, Chang-Wei Su, Tsung-Chen Chi, Yu-Chiuan Chang, Yuk-Kwan Chen, Yen-Yun Wang
Summary: Oral cancer is a highly prevalent malignancy worldwide, and cancer stemness may hinder its management. This study reveals that MRE11 enhances the malignancy of OSCC cells through the induction of CD44.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, Research & Experimental
Zhanzhan Li, Yanyan Li, Na Li, Liangfang Shen, Aibin Liu
Summary: The study found that GOLGA8B is highly expressed in LUSC metastasis tissue and is significantly associated with distant metastasis-free survival in LUSC patients. Functional assays demonstrated that GOLGA8B promotes tumor metastasis in LUSC cells through the inactivation of STAT3 signaling. These results suggest that GOLGA8B could be a promising target for anti-tumor metastasis therapy in LUSC patients.
Article
Integrative & Complementary Medicine
Shih-Chi Su, Yi-Tzu Chen, Yi-Hsien Hsieh, Wei-En Yang, Chun-Wen Su, Wen-Yu Chiu, Shun-Fa Yang, Chiao-Wen Lin
Summary: Gambogic acid can inhibit cell proliferation and induce apoptosis in oral squamous cell carcinoma by activating the p38-dependent apoptotic pathway. These findings provide potential directions for the development of new treatments for oral cancer.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Hongyu Yuan, Zitong Zhao, Zichan Guo, Liying Ma, Jing Han, Yongmei Song
Summary: This study reveals that TMTC3 activates the GRP78/PERK signaling pathway during ER stress-induced EMT, serving as a potential therapeutic target in SCCs.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ji-Rong Xie, Xiao-Jie Chen, Gang Zhou
Summary: Nuciferine shows potential as a therapeutic agent for oral squamous cell carcinoma (OSCC) by inhibiting cell growth and infiltration, and suppressing the STAT3 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Vahide Saeidi, Nicole Doudican, John A. Carucci
Summary: Primary cutaneous squamous cell carcinoma (cSCC) is the second most common human cancer with a rising incidence of about 1.8 million in the United States annually. Surgery is usually curative, but in some cases, cSCC can metastasize and result in death. The introduction of checkpoint inhibitor immunotherapy has significantly improved treatment outcomes for advanced or metastatic cSCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gink N. Yang, Xanthe L. Strudwick, Claudine S. Bonder, Zlatko Kopecki, Allison J. Cowin
Summary: Cutaneous squamous cell carcinoma (cSCC) is a common type of skin cancer in Caucasian populations, with aggressive metastatic forms having poor patient outcomes. Studies have shown that the actin-remodeling protein Flightless (Flii) plays a role in regulating cSCC proliferation and tumor progression through the Wnt/β-catenin signaling pathway. Knockdown of Flii led to decreased β-catenin and a reduction in the downstream effector protein SOX9, indicating its potential as a target for aggressive metastatic cSCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Ji Su Sun, Dong Joo Yang, Ann W. Kinyua, Seul Gi Yoon, Je Kyung Seong, Juwon Kim, Seok Jun Moon, Dong Min Shin, Yun-Hee Choi, Ki Woo Kim
Summary: The dysfunction of primary cilia in the ventromedial hypothalamus is linked to impaired energy and skeletal homeostasis, resulting in obesity and increased bone density. Dysfunction of VMH primary cilia leads to decreased sympathetic activation and central leptin resistance, impacting energy expenditure and bone metabolism.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Dentistry, Oral Surgery & Medicine
Sukjoon Lee, Dongzi Chen, Munsu Park, Sunil Kim, Yoon Jeong Choi, Seok Jun Moon, Dong Min Shin, Ji Hyun Lee, Euiseong Kim
Summary: Single-cell RNA sequencing revealed distinct gene expression patterns in specific clusters of human dental pulp stem cells (hDPSCs) and human periodontal ligament stem cells (hPDLSCs). hDPSCs exhibited osteogenic and neurogenic cell populations, while hPDLSCs mainly comprised osteogenic and myofibroblastic populations. The results can serve as valuable resources for further research in dental therapeutics.
JOURNAL OF ENDODONTICS
(2022)
Article
Toxicology
Dongun Lee, Peter Chang-Whan Lee, Jeong Hee Hong, Dong Min Shin
Summary: The study found that 8-estradiol treatment attenuated the oxalate or bicarbonate transporting activities through SLC26A6 and enhanced cancer cell migration. Even in the presence of 8-estradiol treatment, increased SLC26A6 expression weakened cellular migration. These results suggest that 8-estradiol treatment enhances cancer cell migration by inhibiting SLC26A6 activity.
TOXICOLOGY IN VITRO
(2022)
Article
Oncology
Meiling Pei, Dawool Han, Ki-Yeol Kim, Dong Wook Kim, Woong Nam, Hyung Jun Kim, Eunae Sandra Cho, Hyun Sil Kim, In-Ho Cha, Xianglan Zhang
Summary: The width and dysplasia of surgical margins were not significantly associated with the outcome of OSCC patients. Higher age, Axin2, and Snail expression had independent impacts on worsened overall survival. Lesion site, extranodal extension, perineural invasion, and Snail expression had independent impacts on worsened recurrence-free survival. Axin2 and Snail are potential predictive biomarkers for the risk assessment of surgical margins in OSCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jin-Kyoung Shim, Seonah Choi, Seon-Jin Yoon, Ran Joo Choi, Junseong Park, Eun Hee Lee, Hye Joung Cho, Suji Lee, Wan-Yee Teo, Ju Hyung Moon, Hyun Sil Kim, Eui Hyun Kim, Jae-Ho Cheong, Jong Hee Chang, Jong In Yook, Seok-Gu Kang
Summary: The inhibition of fatty acid oxidation (FAO) has been found to significantly affect the treatment outcomes of glioblastoma (GBM). The combination of etomoxir (ETO) and temozolomide (TMZ) shows superior suppression effects on GBM cell growth and invasiveness, leading to improved survival rates.
CANCER CELL INTERNATIONAL
(2022)
Article
Orthopedics
Cheol-Hee Jeong, Jooseong Kim, Hyun Sil Kim, Song-Yi Lim, Dawool Han, Aaron J. Huser, Sang Bae Lee, Yeonji Gim, Jeong Hyun Ji, Dohun Kim, Amaal M. Aldosari, Kyelim Yun, Yoon Hae Kwak
Summary: In this study, three types of OCPs were compared to commercially available 8-TCP for their potential to promote bone formation in rat tibias with defects. The results showed that OCP/Alg was equivalent to 8-TCP in promoting bone bridge formation and had better biodegradability. OCP/Col accelerated bone formation in defect repair.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Oncology
Seo Jin Kim, Soo Jeong Park, Junseong Park, Hye Joung Cho, Jin-Kyoung Shim, Jieun Seon, Ran Joo Choi, Seon-Jin Yoon, Ju Hyung Moon, Eui Hyun Kim, Eui Kyo Seo, Sun Ho Kim, Hyun Sil Kim, Wan-Yee Teo, Jong Hee Chang, Jong In Yook, Seok-Gu Kang
Summary: The study evaluated the therapeutic effects and underlying mechanisms of dual inhibition of CPT1A and G6PD in GBM, and found that this treatment approach effectively suppressed tumor growth and invasion, and extended survival in GBM mice models.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Sang Hyun Song, Dawool Han, Kyeonghui Park, Jo Eun Um, Seonghun Kim, Minhee Ku, Jaemoon Yang, Tae-Hyun Yoo, Jong In Yook, Nam Hee Kim, Hyun Sil Kim
Summary: Diabetic nephropathy is a common complication of diabetes. The newly discovered cell death mechanism called ferroptosis, induced by TGF-beta, is involved in kidney damage in diabetic nephropathy. BMP7, a known antagonist of TGF-beta, can inhibit TGF-beta-induced fibrosis and play a role in the regeneration of pancreatic beta cells in diabetic animal models.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Engineering, Biomedical
Cheol Hee Jeong, Song-Yi Lim, Jo Eun Um, Hyo Won Lim, Kyu Ho Hwang, Kyeong-Mee Park, Jun Seop Yun, Dohun Kim, Jong-Ki Huh, Hyun Sil Kim, Jong In Yook, Nam Hee Kim, Yoon Hae Kwak
Summary: This study introduces micellized bone morphogenetic protein-2 (mPTD-BMP-2), a next-generation osteogenic supplement that combines protein transduction domain (PTD) and nano-sized micelle formulation technique to improve transduction efficiency and stability. The use of PTD represents a novel approach, and our results demonstrate the superiority of mPTD-BMP-2 over rh-BMP-2 in terms of in vivo pharmacokinetic profile and osteogenic potential, particularly in a rat tibial model of distraction osteogenesis.
ACTA BIOMATERIALIA
(2023)
Article
Veterinary Sciences
Chun-Geun Kim, Ga-Won Lee, Hyun Sil Kim, Seung-Yong Han, Dawool Han, Hee-Myung Park
Summary: This article describes the clinical features, diagnostic imaging, and histologic features of an unreported ghost cell odontogenic carcinoma (GCOC) in a dog, as well as the favorable outcome following surgical resection.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Seul Ki Kim, Le Trung Tran, Cherl NamKoong, Hyung Jin Choi, Hye Jin Chun, Yong-ho Lee, MyungHyun Cheon, ChiHye Chung, Junmo Hwang, Hyun-Ho Lim, Dong Min Shin, Yun-Hee Choi, Ki Woo Kim
Summary: Small humanin-like peptide 2 (SHLP2), a mitochondrial-derived peptide, plays a crucial role in energy homeostasis. The study demonstrates that SHLP2 can protect mice from high-fat diet-induced obesity and improve insulin sensitivity. It activates pro-opiomelanocortin (POMC) neurons in the hypothalamus, which suppresses food intake and promotes thermogenesis. The researchers also discover that SHLP2 binds to and activates chemokine receptor 7 (CXCR7).
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Jun Seop Yun, Hyeeun Song, Nam Hee Kim, So Young Cha, Kyu Ho Hwang, Jae Eun Lee, Cheol-Hee Jeong, Sang Hyun Song, Seonghun Kim, Eunae Sandra Cho, Hyun Sil Kim, Jong In Yook
Summary: The N protein of SARS-CoV-2 is phosphorylated by GSK-3, and this phosphorylation is critical for viral replication. This study identified the GSK-3 interacting domain (GID) and mutations in N that contribute to increased phosphorylation, potentially influencing the evolution of variants.
MOLECULES AND CELLS
(2022)
Article
Ophthalmology
Bo Yi Kim, Soo Hyun Choi, Ji-Young Kim, JaeSang Ko, Jong In Yook, Hyun Sil Kim, Eun Jig Lee, Don O. Kikkawa, Jin Sook Yoon
Summary: This study aimed to investigate the role of bone morphogenic protein 7 (BMP7) in the pathogenic mechanism of Graves' orbitopathy (GO). The results showed that BMP7 mRNA levels were lower in GO orbital tissues compared to normal control tissues. Treatment with recombinant human BMP7 (rhBMP7) suppressed the production of fibrosis-related proteins and pro-inflammatory cytokines in orbital fibroblasts. These findings suggest that BMP7 has potential therapeutic effects by counteracting the profibrotic TGF-beta/SMAD signaling and proinflammatory cytokine production.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Minjeong Ji, Hee Jung Ryu, Hyeon-Man Baek, Dong Min Shin, Jeong Hee Hong
Summary: The study found that modulation of the migratory module of fibroblast-like synoviocytes (FLSs) can attenuate the severity of rheumatoid arthritis (RA). The sodium bicarbonate cotransporter n1 (NBCn1) was identified in RA-FLSs and inhibiting NBCs reduced FLS migration and RA symptoms.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Oncology
Kyungjoo Cho, Nam Hee Kim, Sang Hyun Seo, Sang Hyun Song, Chul Hee Jeong, Hyun Sil Kim, Jo Eun Um, Minhee Ku, Jaemoon Yang, Jun Yong Park, Sang Hoon Ahn, Jong In Yook, Seung Up Kim
Summary: In this study, a micelle formulation containing bone morphogenetic protein-7 (BMP-7) was designed and tested in a mouse liver fibrosis model. The results showed that the formulation effectively suppressed the signaling pathway of transforming growth factor-beta (TGF-beta), leading to improvement in liver fibrosis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)