期刊
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
卷 39, 期 8, 页码 756-763出版社
CHINESE ACAD SCIENCES, INST BIOPHYSICS
DOI: 10.3724/SP.J.1206.2012.00297
关键词
Alzheimer's disease (AD); metal iron homeostasis disruption; oxidative stress; beta-amyloid (A beta); amyloid precursor protein (APP); iron regulatory protein (IRP); divalent metal transporter 1 (DMT1); natural antioxidants
资金
- National Natural Science Foundation of China [30930036, 30870587]
Many studies have shown there is a close relationship between metal homeostasis disruption and Alzheimer's disease (AD), but the mechanism needs to be discussed. Recent progresses about these studies are reviewed especially the results in author's laboratory are discussed. lion and copper homeostasis disruption, oxidative stress, beta-amyloid (A beta), amyloid precursor protein (APP), iron regulatory protein (IRP) and divalent metal transporter 1(DMT1) are discussed in detail. We suggested that the overload of iron and copper might have closer relationship with the oxidative stress damage in the later phase in AD and the deficiency of iron and copper might have closer relationship with the early initiation of AD. The protective effects of natural antioxidant against AD through regulating iron and copper homeostasis disruption and oxidative stress are also discussed. This review may be useful for further research and prevention and therapy of AD.
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