Article
Chemistry, Medicinal
Daniel L. Priebbenow, Mitch Mathiew, Da-Hua Shi, Jitendra R. Harjani, Julia G. Beveridge, Marina Chavchich, Michael D. Edstein, Sandra Duffy, Vicky M. Avery, Robert T. Jacobs, Stephen Brand, David M. Shackleford, Wen Wang, Longjin Zhong, Given Lee, Erin Tay, Helena Barker, Elly Crighton, Karen L. White, Susan A. Charman, Amanda De Paoli, Darren J. Creek, Jonathan B. Baell
Summary: A series of novel 3,3'-disubstituted-5,5'-bi(1,2,4-triazine) compounds with potent in vitro activity against Plasmodium falciparum parasites were recently discovered. The new structure-activity relationship investigation led to the identification of second-generation highly potent antimalarial bis-triazines, with improved in vitro metabolic stability and a fast-killing profile. This new class of orally available antimalarial compounds is of considerable interest.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Mihaela Peric, Dijana Pesic, Sulejman Alihodzic, Andrea Fajdetic, Esperanza Herreros, Francisco Javier Gamo, Inigo Angulo-Barturen, Maria Belen Jimenez-Diaz, Santiago Ferrer-Bazaga, Maria S. Martinez, Domingo Gargallo-Viola, Amanda Mathis, Albane Kessler, Mihailo Banjanac, Jasna Padovan, Vlatka Bencetic Mihaljevic, Vesna Munic Kos, Mirjana Bukvic, Vesna Erakovic Haber, Radan Spaventi
Summary: Novel fast-acting azalides showed high activity against drug-resistant Plasmodium falciparum in vitro and demonstrated excellent antimalarial activity in a murine model. Pharmacokinetic analysis revealed stable metabolism, making these compounds ideal candidates for antimalarial therapy.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Aleena L. Patel, Lili Zhang, Shannon E. Keenan, Christine A. Rushlow, Cecile Fradin, Stanislav Y. Shvartsman
Summary: This study investigates the dynamics of transcriptional repression by Capicua (Cic) in early Drosophila embryos, revealing the speed limit and mechanism of rapid gene repression by Cic. It sets quantitative constraints on potential mechanisms for gene regulation by Cic, providing insights for future studies in gene regulation mechanisms.
Review
Nanoscience & Nanotechnology
Wei Li, Jie Tang, Dennis Lee, Thomas R. Tice, Steven P. Schwendeman, Mark R. Prausnitz
Summary: Long-acting drug delivery formulations enable sustained and prolonged drug release, improving patient compliance. This review discusses FDA-approved long-acting drug delivery formulations, including different slow-release mechanisms and materials, and provides a comprehensive summary of their clinical applications and product information.
NATURE REVIEWS MATERIALS
(2022)
Article
Virology
Alberto Borghetti, Damiano Farinacci, Arturo Ciccullo, Alex Dusina, Davide Moschese, Valentina Iannone, Anna D'Angelillo, Francesca Lombardi, Valentina Delle Donne, Valentina Massaroni, Elena Visconti, Enrica Tamburrini, Simona Di Giambenedetto
Summary: This study examined the eligibility criteria for HIV-positive patients to switch to injectable therapy using cabotegravir and rilpivirine. The results showed a considerable proportion of patients did not meet the eligibility criteria, mainly due to virological failures, resistance mutations, etc. Additionally, fertile women were excluded due to the lack of data on this combination during pregnancy and breastfeeding.
JOURNAL OF MEDICAL VIROLOGY
(2022)
News Item
Medicine, General & Internal
Rita Rubin
Summary: This medical news article discusses zuranolone, the first approved medication for postpartum depression.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Chemistry, Medicinal
Guang Huang, Claribel Murillo Solano, Joel Melendez, Sabrina Yu-Alfonzo, Rachasak Boonhok, Hui Min, Jun Miao, Debopam Chakrabarti, Yu Yuan
Summary: A series of fast-acting, multistage antimalarial agents were synthesized, with compound 60 showing the strongest antimalarial activity and targeting both life stages of the malarial parasites. The results suggest that compound 60, as a fast-acting antimalarial compound, may serve as a candidate for new antimalarial drugs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Clemente F. Arias, Francisco J. Acosta, Cristina Fernandez-Arias
Summary: The initial stage of malaria infection occurs inside the host's hepatocytes. The parasite traverses multiple hepatocytes before infecting definitive host cells, possibly to trigger an immune response. This discovery challenges current understanding of malaria and suggests new strategies to combat the disease.
Article
Pharmacology & Pharmacy
Minyoung Noh, Haiying Zhang, Hyejeong Kim, Songyi Park, Young-Myeong Kim, Young-Guen Kwon
Summary: Endothelial barrier integrity is crucial for vascular homeostasis, while hyperpermeability is involved in the progression of various pathological conditions. Primaquine diphosphate (PD), originally an antimalarial drug, shows potential as a blocker of vascular leakage by maintaining endothelial integrity. This effect is achieved by inhibiting VEGF-induced disruption and stabilizing cortactin actin rings through the mechanism of ubiquitin specific protease 1 (USP1) inhibition.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Matthew N. O'Brien Laramy, Karthik Nagapudi
Summary: Ocular long-acting injectables and implants can reduce treatment burden, improve treatment adherence, and persistence. Further technological advancement is needed to create biodegradable LAIIs with extended release durations and compatibility with a broader array of therapeutic modalities.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Biochemistry & Molecular Biology
Liyuan Zhang, Zhaohua Liu, Yunrui Zhang, Yuewu Xie, Jie Xing
Summary: Hepatotoxicity and nephrotoxicity were observed in mice after exposure to high doses of piperaquine (PQ), while its metabolite M1 showed weaker toxicity. The inflammatory NF-KB pathway and apoptosis pathway mediated the hepatotoxicity of PQ and its N-oxidation metabolite.
CURRENT DRUG METABOLISM
(2021)
Article
Cell Biology
Olivier Benichou, Tamer Coskun, Malgorzata D. Gonciarz, Parag Garhyan, Andrew C. Adams, Yu Du, James D. Dunbar, Jennifer A. Martin, Kieren J. Mather, Richard T. Pickard, Vincent L. Reynolds, Deborah A. Robins, Simbarashe P. Zvada, Paul J. Emmerson
Summary: GDF15 and its receptor GFRAL/RET have a role in regulating food intake and body weight. A GDF15 analog, LY3463251, is a potent agonist at the GFRAL/RET receptor with prolonged pharmacokinetics. In preclinical and clinical studies, LY3463251 reduces food intake and body weight, although the weight loss is modest and there are side effects of nausea and emesis.
Article
Multidisciplinary Sciences
Manse Kim, Claire E. Johnson, Alan A. Schmalstig, Ayano Annis, Sarah E. Wessel, Brian Van Horn, Amanda Schauer, Agata A. Exner, Jason E. Stout, Angela Wahl, Miriam Braunstein, J. Victor Garcia, Martina Kovarova
Summary: This study develops a long-acting delivery system for the anti-tuberculosis drug rifabutin, which is made of biodegradable polymers and biocompatible solvents. The formulation shows high drug load and sustained drug release, and demonstrates translational potential in animal models.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Miaomiao Wang, Yang Wang, Wang Yao, Xing Du, Qifa Li
Summary: This study identifies a novel long noncoding RNA (lncRNA) lnc2300 that regulates the miR-365-3p/CYP11A1 signaling pathway, and contributes to the regulation of granulosa cell (GC) apoptosis during ovarian follicular atresia.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Eleanor Williams, Jana Bagarova, Georgina Kerr, Dong-Dong Xia, Elsie S. Place, Devaveena Dey, Yue Shen, Geoffrey A. Bocobo, Agustin H. Mohedas, Xiuli Huang, Philip E. Sanderson, Arthur Lee, Wei Zheng, Aris N. Economides, James C. Smith, Paul B. Yu, Alex N. Bullock
Summary: Saracatinib, identified as a potent ALK2 kinase inhibitor, demonstrated efficacy in inhibiting heterotopic ossification in FOP models, offering accelerated path to clinical proof-of-efficacy studies and potentially significant benefits to individuals with this condition.
Article
Urology & Nephrology
Zhenjie Wu, Qi Chen, Hooman Djaladat, Andrea Minervini, Robert G. Uzzo, Chandru P. Sundaram, Koon H. Rha, Mark L. Gonzalgo, Reza Mehrazin, Elio Mazzone, Jamil Marcus, Alyssa Danno, James Porter, Aeen Asghar, Fady Ghali, Georgi Guruli, Antoin Douglawi, Giovanni Cacciamani, Alireza Ghoreifi, Giuseppe Simone, Vitaly Margulis, Matteo Ferro, Riccardo Tellini, Andrea Mari, Abhishek Srivastava, James Steward, Ali Al-Qathani, Ahmad Al-Mujalhem, Amit Satish Bhattu, Alexander Mottrie, Firas Abdollah, Daniel D. Eun, Ithaar Derweesh, Alessandro Veccia, Riccardo Autorino, Linhui Wang
Summary: A scoring system based on clinical variables can accurately predict renal insufficiency for cisplatin-based adjuvant chemotherapy after minimally invasive RNU, and it may serve as a tool for patient selection.
EUROPEAN UROLOGY FOCUS
(2022)
Article
Microbiology
Mariko Kanai, Tomas Yeo, Victor Asua, Philip J. Rosenthal, David A. Fidock, Sachel Mok
Summary: The study presents a SNP-based genotyping method that enables the rapid characterization of drug resistance in Plasmodium falciparum parasites. The method utilizes both multiplexed fragment analysis and gel electrophoresis to distinguish different strains. The results demonstrate the potential applications of the method in drug resistance screening, verifying SNP-editing, identifying novel genetic cross progeny, and inferring geographical origins.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Chemistry, Physical
Maksym F. Prodanov, Chengbin Kang, Swadesh K. Gupta, Valerii V. Vashchenko, Yuhao Li, Minchao Qin, Xinhui Lu, Abhishek K. Srivastava
Summary: In this study, a new ligand combination is proposed to achieve mutually parallel alignment of nanorods, leading to the fabrication of high concentration and high brightness hybrid films. These films exhibit excellent performance in display backlight applications.
Editorial Material
Biochemistry & Molecular Biology
Photini Sinnis, David A. Fidock
Summary: In 2020, malaria caused the death of an estimated 627,000 individuals worldwide, with a majority of deaths occurring in children under the age of five in Africa. The recent approval of the RTS,S/AS01 vaccine by the World Health Organization (WHO) offers hope in combating the current resurgence of malaria through combined interventions.
Review
Microbiology
Sudhir K. Upadhyay, Abhishek K. Srivastava, Vishnu D. Rajput, Prabhat K. Chauhan, Ali Asger Bhojiya, Devendra Jain, Gyaneshwer Chaubey, Padmanabh Dwivedi, Bechan Sharma, Tatiana Minkina
Summary: The interaction between plant roots and microorganisms in the rhizosphere has a significant impact on plant growth and productivity. The components of root exudates are closely associated with the microbial population, particularly plant growth-promoting rhizobacteria (PGPR). However, there is currently insufficient information available to develop effective bio-inoculation/bio-fertilizers for specific crops. It is necessary to identify suitable PGPR candidates to meet the needs of plant growth and yield.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Applied
Abhishek Srivastava, Radhey Mohan Naik, Jyoti Rai, Indresh Kumar, Bushra Yaseen, Chinky Gangwar
Summary: The kinetic investigation of the Hg(II)-promoted reaction between [Fe(CN)(6)](4-) and 2,2'-bipyridine (Bipy) in anionic SDS micellar medium was examined. The results showed that pH, [Hg2+], and [SDS] were the crucial factors affecting the reaction rate.
JOURNAL OF SURFACTANTS AND DETERGENTS
(2023)
Article
Biotechnology & Applied Microbiology
P. K. Tiwari, J. Yadav, A. K. Singh, R. Srivastava, A. K. Srivastava, P. K. Sahu, A. K. Saxena
Summary: In this study, the fungal plant growth promoter Penicillium oxalicum T4 was found to have the potential to promote wheat growth and improve root architecture. Gene expression studies revealed that T4 modulated key genes affecting root hair development. These findings suggest that P. oxalicum T4 could be beneficial for wheat and other cereal crops.
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Editorial Material
Parasitology
Mariko Kanai, Laura M. Hagenah, Elizabeth A. Ashley, Kelly Chibale, David A. Fidock
Summary: Recent progress has been made in the field of malaria research, specifically in the areas of antimalarial drug resistance and discovery. A conference held in Breckenridge, Colorado in April 2022 provided a platform for scientists to share advancements in this field, bringing together experts, postdocs, and students from around the world.
TRENDS IN PARASITOLOGY
(2022)
Article
Chemistry, Physical
Priya Singh, Neelam Kumari, Ankur Kaul, Abhishek Srivastava, Vijay Kumar Singh, Krishna Srivastava, Anjani Kumar Tiwari
Summary: In this study, a new molecule DOTA-MBP was designed and its binding affinity towards translocator protein (TSPO) was evaluated through in-silico studies. The stability of DOTA-MBP as a magnetic resonance contrast agent was assessed. In vivo studies using a mouse model showed that DOTA-MBP could locate lung inflammation and monitor the severity of the disease through radioactivity imaging techniques.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Computer Science, Information Systems
Arun Kumar, Zhijie Wang, Abhishek Srivastava
Summary: This article presents a technique for simplifying classification in resource-constrained IoT nodes. The technique involves selecting representative data points and deploying them on IoT nodes to correctly classify new input data.
ACM TRANSACTIONS ON INTERNET OF THINGS
(2022)
Article
Urology & Nephrology
Seyed Behzad Jazayeri, Lauren Folgosa Cooley, Abhishek Srivastava, Neal Shore
Summary: The treatment landscape for metastatic hormone-sensitive prostate cancer (mHSPC) has undergone significant changes. Combinatorial therapy with ADT and docetaxel or an androgen receptor pathway inhibitor has become the standard of care. Scientific evidence supports the optimization and intensification of this treatment strategy.
EUROPEAN UROLOGY OPEN SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Chengbin Kang, Zhicong Zhou, Jonathan E. Halpert, Abhishek K. Srivastava
Summary: This study proposes a new ink composition using oleylamine and hexylphosphonic acid ligands in combination with a liquid crystal monomer, forming a superior solution for an inkjet-printed color conversion layer. This work provides a simple technique for preparing high-quality perovskite pixels for high-performance displays.
Proceedings Paper
Engineering, Electrical & Electronic
Sheng Ni, Yang Bu, Hanliang Zhu, Valerii V. Vashchenko, Abhishek K. Srivastava, Pavel Neuzil, Levent Yobas
Summary: This paper presents a sub-nL DSC chip capable of measuring liquid samples at a sub-nL volume capacity. The chip achieves a heat-flow resolution of 6.29 nW, the highest among state-of-the-art demonstrations. It features suspended twin membranes and self-enclosed microchannels for minimizing deformations and shifts in the DSC measurements.
2022 IEEE 35TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS CONFERENCE (MEMS)
(2022)
Article
Management
Abhishek Srivastava, Deepti Mehrotra, P. K. Kapur, Vijay Kumar
Summary: This paper presents a method for analyzing and measuring Agile software development attributes using statistical analysis. It proposes a framework to accelerate this process. Through exploratory and confirmatory factor analysis, key independent attributes are identified and their impact on the maturity of Agile adoption is measured.
INTERNATIONAL JOURNAL OF APPLIED MANAGEMENT SCIENCE
(2022)
Article
Computer Science, Software Engineering
In-Young Ko, Abhishek Srivastava, Michael Mrissa
JOURNAL OF WEB ENGINEERING
(2022)
