Article
Biochemistry & Molecular Biology
Santosh L. Gawali, Sandeep B. Shelar, Jagriti Gupta, K. C. Barick, P. A. Hassan
Summary: A facile approach for the preparation of protein conjugated glutaric acid functionalized Fe3O4 magnetic nanoparticles is reported, showing improved colloidal stability and heating efficacy in different media. These nanoparticles exhibit good stability and superparamagnetism, with enhanced heating efficacy compared to the original nanoparticles due to surface passivation by protein. Additionally, they demonstrate biocompatibility with normal cells and substantial cellular internalization in cancer cells, suggesting potential application in hyperthermia therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Nanoscience & Nanotechnology
Julia Nowak-Jary, Beata Machnicka
Summary: Magnetic iron oxide nanoparticles have broad potential applications in medical and biological sciences. They can be used in targeted drug delivery, internal radiotherapy, magnetic resonance imaging, hyperthermia, and radiolabelling. The appropriate design of nanoparticles allows them to be delivered to desired tissues and organs, with an external magnetic field increasing their biodistribution. Factors such as size, shape, surface charge, coating molecules, and route of administration affect their biodistribution. Modern techniques can determine nanoparticle accumulation sites and concentration in isolated tissues or the body in vivo.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Polymer Science
Moises Bustamante-Torres, David Romero-Fierro, Jocelyne Estrella-Nunez, Belen Arcentales-Vera, Estefani Chichande-Proano, Emilio Bucio
Summary: In recent years, a wide range of nanomaterials, including magnetic nanoparticles, have been extensively studied for various purposes. Iron oxide nanoparticles and superparamagnetic iron oxide nanoparticles have attracted significant attention due to their physicochemical and magnetic properties, as well as their compatibility with organic or inorganic compounds. The incorporation of these nanoparticles into hydrogels has garnered interest in the field of biomedicine. This review discusses various synthesis methods for magnetite nanoparticles and introduces different processing techniques for magnetite-based nanocomposites in hydrogels. The characterization techniques commonly used to study magnetic nanoparticles and magnetic gels are also discussed.
Article
Chemistry, Multidisciplinary
Zuzanna Z. Janczuk, Agnieszka Jedrych, Sylwia Parzyszek, Anita Gardias, Jacek Szczytko, Michal Wojcik, Paola Tiberto
Summary: This study reports the preparation of MNPs composites using excess liquid crystal-like ligands, which allows for precise and reversible control of magnetic nanoparticles in thin films, showing great potential for various applications.
Article
Chemistry, Multidisciplinary
Lorenzo Cursi, Silvia Vercellino, Mura M. McCafferty, Emily Sheridan, Vanya Petseva, Laurent Adumeau, Kenneth A. Dawson
Summary: Magnetic nanoparticles are valuable tools for studying complex intracellular bio-nano interactions. By synthesizing biocompatible multifunctional nanoparticles with fluorescent properties, intracellular tracking of nanoparticles can be achieved, providing a promising approach for studying bio-nano interactions.
Article
Chemistry, Multidisciplinary
Xiang Yu, Tianyu Yang, Ruoshui Liu, Di'an Wu, Daming Tian, Tianshi Zhou, Haitao Yan, Shuli He, Hao Zeng
Summary: In this study, the efficiency of alternating current magnetic field and near-infrared heating is enhanced by co-doping Zn and Co in magnetite nanoparticles. Optimum magnetic anisotropy is achieved by tuning the doping concentration to maximize the loss power under each magnetic field. The specific loss power of the nanoparticles greatly exceeds previous levels, making it a promising nanoplatform for multi-modal local hyperthermia therapy.
Review
Chemistry, Multidisciplinary
Is Fatimah, Ganjar Fadillah, Septian P. Yudha
Summary: The paper presents a review on the development of iron oxide-based magnetic nanocomposites, focusing on the synthesis methods, materials, and various factors influencing their properties. Future perspectives for development are also highlighted in the study.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Engineering, Chemical
Eva Krolitzki, Sabrina Steck, Andja Nazifi, Michael Abt, Sebastian P. Schwaminger, Sonja Berensmeier
Summary: Magnetic separation is a powerful tool for capturing and purifying biomolecules and cells directly from complex feed media. By characterizing the equipment using in-line analytics and conducting various experiments, we developed an optimized operation protocol for efficient buffer exchange and minimal particle carryover. We demonstrated the versatility of this approach by tailoring it for lactoferrin separation from crude acid whey.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Riku Kawasaki, Yoshihiro Sasaki, Tomoki Nishimura, Kiyofumi Katagiri, Kei-ichi Morita, Yurina Sekine, Shin-ichi Sawada, Sada-atsu Mukai, Kazunari Akiyoshi
Summary: Protein transduction using magnetic nanogel chaperone (MC) shows efficient delivery of anti-cancer proteins into tumor cells and inhibits cell proliferation via apoptosis. In vivo imaging demonstrates that MC accumulates in tumor tissues three times more under a magnetic field, showing promise for cancer therapeutics.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Engineering, Chemical
Jesus Roberto Vargas-Ortiz, Carmen Gonzalez, Karen Esquivel
Summary: This review discusses the role, physicochemical properties, potential applications, and toxicological effects of magnetic nanoparticles (MNPs) in complex biological systems. MNPs have been widely used in various industries, leading to increased interactions with biological organisms. However, the full impact of these particles on complex biological systems and the toxicology aspects of their biomedical applications remain unclear, with mixed and inconclusive results. A consolidative framework that considers the physicochemical properties and potential risks of MNPs is necessary for their future manageable applications.
Article
Chemistry, Multidisciplinary
Feixiang Hu, Dan Wang, Xiaowen Ma, Tingdan Hu, Yali Yue, Wei Tang, PuYe Wu, Tong Tong, Weijun Peng
Summary: The purpose of this study is to develop a T (2) MRI negative contrast agent with a controllable size and explore the feasibility of dual contrast enhancement by combining T (2) with CEST contrast agents. The study was conducted in vitro with HCT-116 human colon cancer cells. Fe3O4 nanoparticles (NPs) with a controllable size and no toxicity were successfully synthesized, and by combining them with a CEST contrast agent, the two contrast agents could be imaged simultaneously.
Article
Chemistry, Physical
Russell J. Wilson, Yue Hui, Andrew K. Whittaker, Chun-Xia Zhao
Summary: A novel biomimetic method for preparing silica nanocapsules loaded with iron oxide nanoparticles is reported in this study, showing excellent stability and drug loading efficiency for drug delivery applications.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Applied
Mahboobeh Zare, Malihe Noruzi Sarkati
Summary: In this study, Fe3O4 magnetic nanoparticles (MNPs) functionalized hyaluronic acid (HA)-folic acid (FA) were synthesized and piperine (PIP) was loaded into MNPs. The synthesized MNPs released a higher amount of piperine in acidic ambience, exhibited higher antioxidant activity, and showed no hemolysis effect. Moreover, the MNPs demonstrated significant antiproliferative effects in MCF-7 cancer cells. These findings suggest that Fe3O4-NH-HA-FA MNPs can enhance the therapeutic effect of piperine as a targeted delivery system.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Pedro Farinha, Joao M. P. Coelho, Catarina Pinto Reis, Maria Manuela Gaspar
Summary: Magnetic nanoparticles (MNPs) have been widely studied for diagnostic purposes in medicine, especially in Magnetic Resonance Imaging (MRI). Current research focus is on developing MNPs with better safety profiles and enhanced magnetic properties to overcome challenges in their market entry.
Article
Engineering, Chemical
David Lokhat, Sonal Brijlal, Durante Emil Naidoo, Cemaine Premraj, Ebrahim Kadwa
Summary: This study demonstrates the effect of in situ magnetic separation on the size and shape of iron oxide nanoparticles produced through coprecipitation. The magnetic array efficiently removes the nanoparticles from the reaction front, preventing their further growth and agglomeration. This method is applicable for large-scale production of iron oxide nanoparticles with tuned size and morphology.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2022)
Article
Immunology
Wan-Chi Liu, Chao-Shun Lin, Chun-Chieh Yeh, Hsin-Yun Wu, Yuarn-Jang Lee, Chi-Li Chung, Yih-Giun Cherng, Ta-Liang Chen, Chien-Chang Liao
JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Multidisciplinary Sciences
Chuen-Chau Chang, Ta-Liang Chen, Chao-Shun Lin, Chi-Li Chung, Chun-Chieh Yeh, Chaur-Jong Hu, Hsin-Long Lane, Chien-Chang Liao, Chun-Chuan Shih
Article
Multidisciplinary Sciences
Yih-Giun Cherng, Chao-Shun Lin, Chun-Chuan Shih, Yung-Ho Hsu, Chun-Chieh Yeh, Chaur-Jong Hu, Ta-Liang Chen, Chien-Chang Liao
Article
Multidisciplinary Sciences
Chao-Shun Lin, Chun-Chuan Shih, Chun-Chieh Yeh, Chaur-Jong Hu, Chi-Li Chung, Ta-Liang Chen, Chien-Chang Liao
Article
Transplantation
Chun-Chieh Yeh, Arshad Khan, Chih-Hsin Muo, Horng-Ren Yang, Ping-Chun Li, Chao-Hsiang Chang, Ta-Liang Chen, Long-Bin Jeng, Chien-Chang Liao
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2020)
Article
Oncology
Chun-Chieh Yeh, Pei-Ying Liao, Sudhir Pandey, Su-Yung Yung, Hsueh-Chou Lai, Long-Bin Jeng, Wei-Chun Chang, Wen-Lung Ma
FRONTIERS IN ONCOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Tuyen Thi Do, Chun-Chieh Yeh, Guo-Wei Wu, Chia-Chen Hsu, Hung-Chih Chang, Hui-Chen Chen
Summary: TRIM37 plays a crucial role in promoting pancreatic cancer progression by enhancing cancer cell proliferation and invasion. Knockdown of TRIM37 inhibits tumor growth and reduces the proportion of immunosuppressive macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Immunology
H. -R Yang, A. Thorat, L. -B Jeng, S. -C Hsu, T. -H Chen, C. -C Yeh, P-C Li, K. -S Poon
Meeting Abstract
Surgery
A. Thorat, L. -B. Jeng, S. -C. Hsu, C. -C. Yeh, T. -H. Chen, H. -R. Yang, K. -S. Poon, P. -C. Li
AMERICAN JOURNAL OF TRANSPLANTATION
(2018)
Article
Surgery
Horng-Ren Yang, Ashok Thorat, Long-Bin Jeng, Shih-Chao Hsu, Ping-Chun Li, Chun-Chieh Yeh, Te-Hung Chen, Kin-Shing Poon
ANNALS OF TRANSPLANTATION
(2018)
Meeting Abstract
Immunology
A. Thorat, S. -C. Hsu, H. -R. Yang, K. -S. Poon, C. -C. Yeh, T. -H. Chen, L. -B. Jeng
Meeting Abstract
Immunology
A. Thorat, L. -B. Jeng, S. -C. Hsu, H. -R. Yang, C. -C. Yeh, T. -H. Chen, P. -C. Li, K. -S. Poon
Article
Integrative & Complementary Medicine
Chun-Chuan Shih, Lu-Hsiang Huang, Chun-Chieh Yeh, Hsin-Long Lane, Chang-Ju Hsieh, Chin-Chuan Tsai, Li-Wei Lin, Ta-Liang Chen, Chien-Chang Liao
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2017)
Article
Surgery
Shih-Chao Hsu, Ashok Thorat, Kin-Shing Poon, Chun-Chieh Yeh, Te-Hung Chen, Horng-Ren Yang, Long-Bin Jeng
ANNALS OF TRANSPLANTATION
(2017)
Article
Anesthesiology
H. C. Chang, C. C. Liao, C. C. Chang, S. Y. Huang, C. C. Yeh, C. J. Hu, Y. G. Cherng, T. L. Chen