Review
Biochemistry & Molecular Biology
Geoffrey Brown, Kevin Petrie
Summary: Cancer stem cells (CSCs) drive the hierarchies of dividing cells in cancer and are a major factor in cancer metastasis and relapse. Targeting non-dividing CSCs could improve cancer therapy, with RAR gamma antagonism potentially offering a strategy to treat metastatic disease, relapse, and cure some cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yuzhou Feng, Jiahao Yi, Lin Yang, Yanfei Wang, Jianguo Wen, Weiling Zhao, Pora Kim, Xiaobo Zhou
Summary: This article discusses the severe consequences of the COVID-19 pandemic caused by SARS-CoV-2, including the impact of virus mutations on transmission and immune evasion. The article points out that there is currently a lack of research on the relationship between mutations and factors such as disease severity and viral transmission. To address this gap, the authors constructed a functional annotation database for SARS-CoV-2 genetic variation.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Meizi Wang, Shudong Li, Ee-Chon Teo, Gusztav Fekete, Yaodong Gu
Summary: The therapeutic benefit of high heel shoes for plantar fasciitis treatment is controversial. Elevating heel height may help distribute body weight and reduce plantar fascia strain, but can also increase the risk of developing plantar fasciitis. The study found that as heel height increased from 3 to 7 cm, strain on the plantar fascia also increased, with the highest strain occurring near the heel pain site.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Neurosciences
P. R. Protachevicz, C. A. Bonin, K. C. Iarosz, I. L. Caldas, A. M. Batista
Summary: The study investigates spike variability in a typical stellate cell under different noise environments using a Hodgkin-Huxley model. Results show that spike variability is influenced by the magnitude of noise current, with the highest variability observed for non-maximal noise currents.
COGNITIVE NEURODYNAMICS
(2022)
Article
Biology
Anish Nag, Subhabrata Paul, Ritesh Banerjee, Rita Kundu
Summary: The world is currently facing a pandemic outbreak of COVID-19 caused by SARS-CoV-2, with the virus entering the human host through interaction with ACE2 protein. While vaccines target the S spike protein, recent mutations in the region may escape vaccine immunity. Curcumin and piperine have been identified as potential therapeutic compounds that can effectively target mutated S spike protein and limit viral entry.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Plant Sciences
Jiazi Zhang, Hongchun Xiong, Huijun Guo, Yuting Li, Xiaomei Xie, Yongdun Xie, Linshu Zhao, Jiayu Gu, Shirong Zhao, Yuping Ding, Luxiang Liu
Summary: This study identified the direct target genes of the wheat Q gene and proposed a possible regulatory network, which helps clarify the mechanism of wheat spike morphology and improve wheat grain yield.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Mechanics
H. K. Moffatt
Summary: This paper provides an informal introduction to topics in fluid dynamics with a topological character, covering flows with boundary singularities, Lagrangian chaos, magnetohydrodynamic analogies, magnetic relaxation, and more. The conclusion poses several open questions regarding these topics.
JOURNAL OF FLUID MECHANICS
(2021)
Article
Biology
Monif AlRashidi
Summary: Bar-tailed Larks prefer nesting under shrub trunks for camouflage and protection. The study found differences in their incubation behavior between day and night, with parents increasing nest attendance at night to prevent lethal temperatures affecting the eggs.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Physics, Multidisciplinary
Francois Gelis
Summary: This article reviews the theoretical aspects relevant to the description of high-energy heavy ion collisions, focusing on the insights into the underlying quantum chromodynamics phenomena that have emerged from these collisions.
REPORTS ON PROGRESS IN PHYSICS
(2021)
Article
Engineering, Multidisciplinary
Anqing Li, Binglei Wang, Shengyou Yang
Summary: This paper reexamines the origin and characteristics of flexoelectricity, proposes a method to decompose the strain gradient into four parts, and reformulates the general isotropic flexoelectric theory based on these decomposed strain gradients.
INTERNATIONAL JOURNAL OF ENGINEERING SCIENCE
(2021)
Article
Biology
Kathryn E. Kistler, Trevor Bedford
Summary: Seasonal coronaviruses, including OC43 and 229E, are undergoing adaptive evolution in regions of the viral spike protein exposed to human immune response, potentially leading to reinfection. This adaptive change may require continual vaccine updates for effective protection against these viruses.
Article
Mathematics, Applied
Muhammad Qasim, Arbaz Jehan Khan, Samirah Alsulami, Shoaib Assar
Summary: In this paper, we investigate the characteristics of separated objects, T0, T1, Pre-T2, and various types of Hausdorff objects in the category of interval spaces and interval-preserving mappings. We also examine their relationships with each other. Additionally, we study the properties of closedness and D-connectedness in interval spaces and introduce the notion of zero-dimensionality in this category, demonstrating its connection to D-connectedness.
Article
Mathematics, Applied
Nasr Anwer Zeyada, Makkiah S. Makki
Summary: This article discusses the properties of Noetherian rings and their relation to injective hulls of modules, and extends these results to simple singular right modules and strongly singular injectivity.
Article
Engineering, Electrical & Electronic
Dao Thanh Hai
Summary: This article represents the first attempt to uncover vulnerabilities in proposals for optical network designs and performance comparisons. The current approach of using heuristic algorithms based on optimization models may lead to unreliable conclusions, as the performance in small-scale tests may not generalize to large-scale scenarios.
OPTICAL AND QUANTUM ELECTRONICS
(2022)
Review
Chemistry, Multidisciplinary
Kyuichi Yasui
Summary: This article reviews the theoretical studies on bulk nanobubbles (UFBs) and discusses their stability, generation, and interaction with solid surfaces. The dynamic equilibrium model is found to be a promising model for UFB stability, and the formation of UFBs is attributed to the production of OH radicals during hydrodynamic or acoustic cavitation. The presence of UFBs accelerates the rupture of liquid film and reduces surface tension. Additionally, the interaction between UFBs and solid surfaces is explored.