Article
Medicine, Research & Experimental
Rasha M. S. M. Mohamed, Enssaf Ahmad Ahmad, Bothina H. F. Omran, Amr T. Sakr, Islam A. A. E-H Ibrahim, Mona F. Mahmoud, Mostafa E. El-Naggar
Summary: This study investigated the role of a and 13-adrenergic receptors (13ARs) in the dexamethasone-induced nephrotoxicity and found that blocking either a1ARs or 13ARs can effectively protect against the nephrotoxicity. However, the combined blocking of a1ARs and 13ARs does not enhance the renal protective effects.
Review
Pharmacology & Pharmacy
Jinhai Luo, Zhiling Yu, Juscelino Tovar, Anne Nilsson, Baojun Xu
Summary: Phytochemicals inhibit adipogenesis and lipid accumulation by activating the Wnt/β-catenin signaling pathway, potentially serving as anti-obesity drugs.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Immunology
Ruqing Gao, Xiaoqiang Zheng, Aimin Jiang, Wangxiao He, Tianya Liu
Summary: The tumor-specific biomimetic Wnt pathway suppressor CM-CA effectively inhibits the Wnt/β-catenin signaling pathway and cellular proliferation in lung adenocarcinoma, leading to significant tumor growth inhibition. CM-CA also promotes T cell infiltration and enhances the immune response within tumor tissues.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Dan Li, Yanan Cao, Juan Wang, Haiyan Yang, Weina Liu, Jinfeng Cui, Wenxin Wu
Summary: High expression of HMGA2 in colorectal cancer tissues compared with adjacent normal tissues suggests its potential involvement in the carcinogenesis of sporadic colorectal tubular adenoma, possibly through synergistic interaction with the Wnt/beta-catenin signaling pathway. Experimental results also indicate coordinated regulation between HMGA2 and Wnt/beta-catenin signaling pathway in carcinogenesis of sporadic colorectal tubular adenoma.
Article
Multidisciplinary Sciences
Yinan Hu, Qi Wang, Jun Yu, Qing Zhou, Yanhan Deng, Juan Liu, Lei Zhang, Yongjian Xu, Weining Xiong, Yi Wang
Summary: This study reveals the involvement of ACP5 in the initiation and progression of pulmonary fibrosis. Acp5 deficiency protects mice from lung injury and fibrosis, and the upregulation of Acp5 by TGF-beta 1 enhances β-catenin signaling, promoting fibroblast differentiation, proliferation, and migration. Furthermore, treatment with Acp5 siRNA or inhibitor can reverse established lung fibrosis.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Yutao Li, Shanhe Wang, Wei Sun
Summary: SRY-box transcription factor 18 (SOX18) is expressed in dermal papilla cells (DPCs) of sheep hair follicles and plays a crucial role in promoting DPC proliferation through activating the Wnt/β-Catenin signaling pathway. Inhibition of the Wnt/β-Catenin signaling pathway can be rescued by SOX18, suggesting the essential role of SOX18 in governing DPC proliferation and hair growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Yangyang Tian, Jiarui Xia, Guo Yang, Chao Li, Yuanmeng Qi, Kai Dai, Chenchen Wu, Yonghua Guo, Wu Yao, Changfu Hao
Summary: We found that A2aR inhibits fibrosis and the EMT process in silicosis by regulating the Wnt/β-catenin pathway. Our study provides an experimental basis for elucidating the role of A2aR in the development of silicosis and offers new ideas for further exploration of interventions for silicosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Nutrition & Dietetics
Pratibha Pandey, Fahad Khan, Sara A. Seifeldin, Khalid Alshaghdali, Samra Siddiqui, Mohamed Elfatih Abdelwadoud, Manish Vyas, Mohd Saeed, Avijit Mazumder, Amir Saeed
Summary: The Wnt pathway is crucial for human development and homeostasis. Dysregulation of this pathway has been linked to cancer. Wnt signaling plays a significant role in the development and metastasis of cancer, and targeting this pathway has become an important focus of cancer research. Flavonoids derived from plants have shown anticancer effects by influencing the Wnt pathway and other signaling pathways. This review comprehensively evaluates the impact of flavonoids on cancer development and metastasis through the Wnt pathway, providing evidence of their impact on molecular targets.
Article
Agriculture, Dairy & Animal Science
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Kai Quan, Tesfaye Getachew, Joram M. M. Mwacharo, Aynalem Haile, Yutao Li, Shanhe Wang, Wei Sun
Summary: In our study, we found that CRABP2 was highly expressed in Hu sheep hair follicles, indicating its potential influence on dermal papilla cells (DPCs). Our experiments demonstrated that overexpression of CRABP2 promoted DPC proliferation and activated the Wnt/beta-catenin pathway. These findings highlight the crucial role of CRABP2 in Hu sheep DPC proliferation and shed light on its function in hair follicles.
Article
Neurosciences
Tao Lv, Min Wang, He-Sheng Zheng, Fan Yang, Le Yang, Ming -Gao Zhao, Shui-Bing Liu, Kun Zhang, Rui Liu, Yu-Mei Wu
Summary: Electroacupuncture (EA) alleviates post-traumatic stress disorder (PTSD) symptoms by regulating the Wnt/beta-catenin signaling pathway, which corrects abnormal synaptic plasticity in the hippocampus (Hipp) by promoting the expression of PSD95 and Syn, increasing the number of dendritic spines, and enhancing the levels of Wnt3a and beta-catenin.
BRAIN RESEARCH BULLETIN
(2023)
Review
Oncology
Esther Martinez-Font, Marina Perez-Capo, Oliver Vogler, Javier Martin-Broto, Regina Alemany, Antonia Obrador-Hevia
Summary: Soft tissue sarcomas are a heterogeneous group of rare tumors originating from mesenchymal tissue, with chemotherapy based on doxorubicin remaining the standard first-line treatment. Understanding the molecular alterations of the WNT signaling pathway in STS is crucial for developing new therapeutic approaches and identifying drug targets.
Article
Biochemistry & Molecular Biology
Ramona D'Amico, Marika Cordaro, Rosalba Siracusa, Daniela Impellizzeri, Angela Trovato Salinaro, Maria Scuto, Maria Laura Ontario, Roberto Crea, Salvatore Cuzzocrea, Rosanna Di Paola, Roberta Fusco, Vittorio Calabrese
Summary: The study investigated the potential beneficial effects of a new compound, Hidrox(R) (HD), in counteracting pain associated with fibromyalgia. Results showed that daily treatment with HD could modulate the WNT/beta-catenin and Nrf2 pathways to attenuate behavioral deficits and microglia activation induced by reserpine injection. This suggests that nutritional consumption of HD could be a new therapeutic approach for human fibromyalgia.
Review
Biochemistry & Molecular Biology
Xiaobin Shang, Kai Oliver Boeker, Shahed Taheri, Thelonius Hawellek, Wolfgang Lehmann, Arndt F. Schilling
Summary: Osteoarthritis is a chronic disease that lacks disease-modifying treatment, with the Wnt/beta-catenin pathway playing a key role in its pathophysiology. Both excessive stimulation and suppression of this pathway can contribute to the development of OA. MicroRNAs have been found to regulate various cellular processes in different diseases, offering potential insights for the development of miRNA-based therapeutics for OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Tabinda Sidrat, Zia-Ur Rehman, Myeong-Don Joo, Kyeong-Lim Lee, Il-Keun Kong
Summary: The Wnt/beta-catenin signaling pathway is crucial in early embryonic development, regulating cell proliferation and maintaining ESCs in a pluripotent state. Dysregulation of this pathway can lead to hereditary diseases and abnormalities. The interaction of Wnt signaling with other molecules and with PPAR delta is important in embryonic development and gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Xinbing Yang, Yajing Du, Lulu Luo, Xinru Xu, Shizheng Xiong, Xueni Yang, Li Guo, Tingming Liang
Summary: Dysregulated expression of specific non-coding RNAs (ncRNAs) has been strongly linked to tumorigenesis, cancer progression, and therapeutic resistance. Recent evidence suggests that ncRNAs can interact with the Wnt/beta-catenin signaling pathway, influencing the expression of Wnt target genes in cancer cells. This review aims to unravel the complex associations between ncRNAs and the Wnt/beta-catenin signaling pathway and explore their potential implications for cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Rizwana Afroz, E. M. Tanvir, Mousumi Tania, Junjiang Fu, Mohammad Amjad Kamal, Md. Asaduzzaman Khan
Summary: This review article focuses on the role of toll-like receptors (TLRs), particularly TLR4, in breast cancer. TLRs are widely investigated pattern recognition receptors and TLR4 is the most studied TLR, associated with the development of various cancers, including breast cancer. Activation of TLR4 occurs through the binding of its ligand lipopolysaccharide (LPS), leading to gene expression related to cancer cell proliferation, survival, invasion, and metastasis. The role of TLR4 in breast cancer growth, invasion, and metastasis is attracting significant attention in oncology research, with potential for therapeutic applications.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ju Zhou, Saber Imani, Marzieh Dehghan Shasaltaneh, Shuguang Liu, Tao Lu, Junjiang Fu
Summary: This study evaluated the antitumor effect of thymoquinone, an active component in Nigella sativa, on two PIK3CA hotspot mutations in breast cancer cells and investigated the mechanistic effects of these mutations on the PI3K/Akt1 pathway using molecular dynamics. The findings demonstrated that the mutations reduced the inhibitory effect of Delta Np63 alpha on PIK3CA, leading to enhanced activity of the PI3K downstream signals.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Junhong Li, Lei Qu, Lingjie Sang, Xinyu Wu, Anlan Jiang, Jian Liu, Aifu Lin
Summary: This review examines the rapidly developing field of micropeptides translated from putative non-coding RNAs, discusses the strategies for their identification, and elucidates their critical roles in many fundamental biological processes.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Oncology
Md. Asaduzzaman Khan, Meiling Zheng, Jiewen Fu, Mousumi Tania, Jun Li, Junjiang Fu
Summary: This study identified IL17RD as a novel target of Thymoquinone (TQ) in triple negative breast cancer (TNBC) cells. TQ treatment inhibited the growth and migration of TNBC cells, and IL17RD overexpression in combination with TQ treatment showed the most effective anti-TNBC effects. Higher expression of IL17RD was associated with longer survival in TNBC patients.
Review
Biochemistry & Molecular Biology
Lei Qui, Xinyu He, Qian Tang, Xiao Fan, Jian Liu, Aifu Lin
Summary: This review summarizes the associations among iron metabolism, ferroptosis, and ferroptosis-related long noncoding RNA (lncRNA) in tumorigenesis. It provides insights into the role of lncRNA in iron metabolism and raises the possibility of targeting lncRNA and ferroptosis in cancer combination therapy.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Biochemistry & Molecular Biology
Lisha Yang, Jiewen Fu, Jingliang Cheng, Baixu Zhou, Xiaoyan Liu, Songyot Anuchapreeda, Junjiang Fu
Summary: A novel pathogenic variant in the NF1 gene was identified in a large Chinese pedigree with NF1 disorder, expanding the NF1 mutation spectrum. Additionally, the expression of NF1 showed low tissue specificity in different human tissues, which may impact the phenotypes of multiple organs.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Jiayue He, Shuguang Liu, Qi Tan, Zhiying Liu, Jiewen Fu, Ting Li, Chunli Wei, Xiaoyan Liu, Zhiqiang Mei, Jingliang Cheng, Kai Wang, Junjiang Fu
Summary: This study evaluated the inhibitory effects of cordycepin, thymoquinone, and N6, N6-dimethyladenosine on ADAM17 in cancer cells and predicted their potential in anti-COVID-19 therapy. The results showed that these compounds suppressed the expression of ADAM17 and had potential against SARS-CoV-2. Pharmacological analysis indicated that ADAM17 might be a target for anti-COVID-19 therapy with these compounds.
Article
Multidisciplinary Sciences
Chengyu Shi, Ying Wang, Minjie Wu, Yu Chen, Fangzhou Liu, Zheyuan Shen, Yiran Wang, Shaofang Xie, Yingying Shen, Lingjie Sang, Zhen Zhang, Zerui Gao, Luojia Yang, Lei Qu, Zuozhen Yang, Xinyu He, Yu Guo, Chenghao Pan, Jinxin Che, Huaiqiang Ju, Jian Liu, Zhijian Cai, Qingfeng Yan, Luyang Yu, Liangjing Wang, Xiaowu Dong, Pinglong Xu, Jianzhong Shao, Yang Liu, Xu Li, Wenqi Wang, Ruhong Zhou, Tianhua Zhou, Aifu Lin
Summary: The TMUB1 protein is involved in regulating the post-translational modifications of PD-L1 in tumor cells. It competes with HUWE1 to interact with PD-L1, inhibiting its polyubiquitination and promoting its stability. Higher levels of TMUB1 are associated with poor patient survival rates. Blocking the TMUB1/PD-L1 interaction can enhance anti-tumor immunity and suppress tumor growth.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Xin-yu He, Xiao Fan, Lei Qu, Xiang Wang, Li Jiang, Ling-jie Sang, Cheng-yu Shi, Siyi Lin, Jie-cheng Yang, Zuo-zhen Yang, Kai Lei, Jun-hong Li, Huai-qiang Ju, Qingfeng Yan, Jian Liu, Fudi Wang, Jianzhong Shao, Yan Xiong, Wenqi Wang, Aifu Lin
Summary: In this study, the authors discovered that an iron-triggered long noncoding RNA called LncRIM regulates cellular iron metabolism through the Hippo-YAP signaling pathway, promoting breast cancer development. They found that LncRIM directly binds NF2 to inhibit NF2-LATS1 interaction, leading to YAP activation and increased intracellular iron levels. Clinical data showed that high expression of LncRIM is associated with poor patient survival, indicating its potential as a biomarker and therapeutic target. This study highlights a novel mechanism involving the LncRIM-NF2 axis in iron-mediated feedback loop that hyperactivates YAP and promotes breast cancer development.
NATURE COMMUNICATIONS
(2023)
Review
Immunology
Xintong He, Ye Sun, Jianzhang Lu, Faiza Naz, Shenglin Ma, Jian Liu
Summary: Cytoplasmic DNA plays a crucial role in the pathogenesis of inflammatory diseases and cancer, including COVID-19 and lung carcinoma. However, understanding the specific roles of various cytoplasmic DNA-related pathways and their interactions in different inflammatory diseases is challenging. This review summarizes the latest findings on cytoplasmic DNA and its signaling pathways in inflammatory lung conditions and lung cancer progression. It provides insights into the development of common lung diseases and discusses the potential immunotherapy strategies by targeting cytoplasmic DNA.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, Legal
Binghui Song, Jie Qian, Junjiang Fu
Summary: Epigenetic markers, particularly non-coding RNAs (ncRNAs) such as miRNA, circRNA, lncRNA, and piRNA, have been extensively studied in forensic medicine due to their unique mode of inheritance. They offer potential strategies and methods for tissue and body fluid identification, cause-of-death analysis, time-related estimation, age estimation, and monozygotic twin identification. This review discusses the research progress, application status, and the value of ncRNAs in forensic practice.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ting Li, Qi Tan, Chunli Wei, Hui Zou, Xiaoyan Liu, Zhiqiang Mei, Pengfei Zhang, Jingliang Cheng, Junjiang Fu
Summary: TQFL12, a novel derivative of Thymoquinone (TQ) extracted from Nigella sativa seeds, was found to be more effective in treating TNBC than TQ. Through in vivo experiments, it was discovered that TQFL12 had significantly lower acute toxicity than TQ, possibly through the AMPK signaling pathway.
Article
Genetics & Heredity
Binghui Song, Jiewen Fu, Jie Qian, Lisha Yang, Jingliang Cheng, Junjiang Fu
Summary: This study evaluated 21 autosomal STR loci in 1959 Han-Chinese individuals from Luzhou area and found no substantial linkage disequilibrium among the markers. These loci were in Hardy-Weinberg equilibrium and had high discrimination power and exclusion probability. The results suggest that historical influences, geographical distribution, cultural integration, and economic development may impact the Luzhou Han population and other Chinese populations.
Article
Genetics & Heredity
Jiewen Fu, Binghui Song, Jie Qian, Ting He, Hanchun Chen, Jingliang Cheng, Junjiang Fu
Summary: This study analyzed the Y-STRs genetic data of male individuals from the Han population in Luzhou, demonstrating high polymorphism. Comparisons with 11 other related Han populations revealed close genetic relationships between Luzhou Han people and Han populations in Sichuan, Guangdong, and Hunan, consistent with geographical distribution, historical influence, and economic development. These findings are of great value for forensic applications and population genetics research.
Article
Biochemistry & Molecular Biology
Xilin Shen, Bingbing Wu, Wei Jiang, Yu Li, Yuping Zhang, Kun Zhao, Nanfang Nie, Lin Gong, Yixiao Liu, Xiaohui Zou, Jian Liu, Jingfen Jin, HongWei Ouyang
Summary: This study quantitatively measured the aging blood transcriptome and identified age-related genes. It revealed the characteristics of linear and non-linear dimensions of aging and evaluated the rejuvenation effect of molecules using an aging clock.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)