Article
Environmental Sciences
Sumiko Morimoto, Edgar Solis-Lemus, Jesica Jimenez-Vivanco, Dafne Castellanos-Ruiz, Eulises Diaz-Diaz, C. Adriana Mendoza-Rodriguez
Summary: A study found that low doses of BPS affected glucose metabolism in rats, causing them to exhibit more female-like responses during the perinatal period. However, these effects disappeared in adulthood.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jessica K. Leet, Catherine A. Richter, Robert W. Gale, Donald E. Tillitt, Jill A. Jenkins
Summary: Reproductive abnormalities have been observed in wild fish in the United States, particularly in largemouth bass and smallmouth bass. Environmental contaminants such as E1, ATR, and EE2 have been found to affect the reproductive condition and function of adult male largemouth bass, with the effects of exposure during early gonad recrudescence persisting through the subsequent spawning cycle.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
N. Spinder, J. E. H. Bergman, M. van Tongeren, H. M. Boezen, H. Kromhout, H. E. K. de Walle
Summary: Maternal occupational exposure to specific EDCs early in pregnancy may increase the risk of CAKUT in offspring. No association was observed between EDC exposure and hypospadias.
HUMAN REPRODUCTION
(2022)
Article
Environmental Sciences
Jialu Bao, Yan Zhang, Linchao Zhang, Xiaodan Wang
Summary: Exposure of pregnant mice to PFOA was found to have a damaging effect on testicular development in male offspring mice, leading to reduced testosterone content and increased apoptosis. Genes associated with snRNA and THOC were dysregulated after PFOA exposure, indicating potential mechanisms underlying the observed effects.
Article
Environmental Sciences
Chengxi Li, Bo Wang, Xue Lu, Yichao Huang, Hua Wang, Dexiang Xu, Jun Zhang
Summary: The research found that maternal cadmium exposure can result in reproductive developmental issues in female offspring on PND21, including delayed vaginal opening, irregular estrous cycle, and inhibited follicular development.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Public, Environmental & Occupational Health
Katia Keglberg Haervig, Kajsa Ugelvig Petersen, Aleksander Giwercman, Karin Sorig Hougaard, Birgit Bjerre Hoyer, Christian Lindh, Cecilia Host Ramlau-Hansen, Anne-Marie Nybo Andersen, Gunnar Toft, Jens Peter Bonde, Sandra Sogaard Tottenborg
Summary: The study indicates that maternal smoking during pregnancy poses a significant risk to the reproductive function of adult males, with no mitigation of effects even if smoking cessation occurs prior to the fetal masculinization programming window.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Engineering, Environmental
Michiel A. van den Dries, Kelly K. Ferguson, Alexander P. Keil, Anjoeka Pronk, Suzanne Spaan, Akhgar Ghassabian, Susana Santos, Vincent W. V. Jaddoe, Leonardo Trasande, Henning Tiemeier, Monica Guxens
Summary: Prenatal exposure to nonpersistent chemical mixtures is associated with lower nonverbal IQ in children, but not emotional and behavioral problems. This exposure is universal and may impact neurodevelopment.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Environmental Sciences
Katia Keglberg Haervig, Kajsa Ugelvig Petersen, Karin Sorig Hougaard, Christian Lindh, Cecilia Host Ramlau-Hansen, Gunnar Toft, Aleksander Giwercman, Birgit Bjerre Hoyer, Esben Meulengracht Flachs, Jens Peter Bonde, Sandra Sogaard Tottenborg
Summary: The study found a consistent inverse association between maternal PFAS exposure and semen quality in young men from the general Danish population. Different PFAS contributed to the associations with varying strengths, with perfluoroheptanoic acid identified as the main contributor in the analyses of all three outcomes. No clear association was observed between exposure to maternal PFAS and testicular volume or reproductive hormones.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Environmental Sciences
Huan He, Wenjing Chen, Yu Wei, Taifa Zhang, Wenfeng Geng, Jinxia Zhai
Summary: This study found a significant association between endocrine-disrupting chemicals and reproductive system damage in F3 generation male rodents, particularly affecting the testis, prostate, and kidney. However, it does not prove that EDCs are adverse factors for puberty abnormalities.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
C. C. Paccola, G. S. Souza, I. M. M. Freitas, J. C. Souza, L. L. Martins, V. Vendramini, S. M. Miraglia
Summary: Nicotine exposure during pregnancy and breastfeeding can potentially harm female gametes, affecting reproductive capacity. However, it does not significantly impact the number of oocytes and fertility in adult rats. Nevertheless, morphological alterations in oocytes, mitochondrial changes, embryonic fragmentation, and disruption of fetal development can still occur as a result of nicotine exposure.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Food Science & Technology
Archana Molangiri, Saikanth Varma, M. Satyavani, Saikrishna Kambham, Asim K. Duttaroy, Sanjay Basak
Summary: Early exposure to bisphenol may result in adverse reproductive health issues in later life. This study investigated the effects of orally administered bisphenol S (BPS) and bisphenol A (BPA) on testicular development in rats. The results showed that prenatal exposure to BPS can lead to changes in plasma testosterone levels, testis histology, inflammation, oxidative stress, and sperm DNA damage, potentially affecting male reproductive functions.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Reproductive Biology
Alana Rezende Godoi, Vanessa Caroline Fioravante, Beatriz Melo Santos, Francisco Eduardo Martinez, Patricia Fernanda Felipe Pinheiro
Summary: The consumption of sodium saccharin by pregnant rats was found to program alterations in the reproductive parameters of male offspring, leading to abnormal testicular development, reduced sperm count, and disrupted reproductive capacity.
BIOLOGY OF REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Kajsa Ugelvig Petersen, Katia Keglberg Haervig, Jens Peter Bonde, Karin Sorig Hougaard, Gunnar Toft, Cecilia Host Ramlau-Hansen, Johan Hoy Jensen, Laura Deen, Sandra Sogaard Tottenborg
Summary: This study aimed to explore the association between maternal stress during pregnancy and reproductive function in young men. Through a nested cohort study in the Danish National Birth Cohort, the authors found no overall negative associations between maternal stress and male reproductive function. However, maternal emotional stress was associated with higher total sperm count, serum estradiol, and calculated free testosterone. The study highlights the need for further validation of stress measurement during pregnancy and improving our understanding of the full spectrum of fetal stress exposures and their consequences for health.
FERTILITY AND STERILITY
(2022)
Article
Environmental Sciences
Senlin Xue, Lianqin Liu, Mengmeng Dong, Wei Xue, Shenrui Zhou, Xiaotian Li, Sihui Guo, Wei Yan
Summary: This study found that prenatal exposure to Bisphenol AF (BPAF) can induce reproductive toxicity in adult male offspring, including testicular impairments and immunological responses through the Aim2-NF-kappa B-IFNs signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Pharmacology & Pharmacy
Maya Berlin, Hadar Flor-Hirsch, Elkana Kohn, Anna Brik, Rimona Keidar, Ayelet Livne, Ronella Marom, Amit Ovental, Dror Mandel, Ronit Lubetzky, Pam Factor-Litvak, Josef Tovbin, Moshe Betser, Miki Moskovich, Ariela Hazan, Malka Britzi, Itai Gueta, Matitiahu Berkovitch, Ilan Matok, Uri Hamiel
Summary: The study aimed to investigate the association between maternal PCBs levels and atopic reactions in their offspring. The findings showed no significant association between exposure to PCBs and asthma, allergic rhinitis, or atopic dermatitis in children. More multi-participant studies with longer follow-up into later pediatric age are needed to further explore these relationships.
FRONTIERS IN PHARMACOLOGY
(2022)