Review
Agriculture, Dairy & Animal Science
J. L. Pate, C. H. K. Hughes
Summary: The corpus luteum plays a critical role in pregnancy in all mammals. However, the fate of the corpus luteum in ruminants depends on the presence of a functional uterus or signals from a developing embryo. Prostaglandin F2alpha, secreted by the uterus, is a key molecule that needs to be modified. The sensitivity of the corpus luteum to prostaglandin F2alpha can be influenced by internal mechanisms. Understanding the molecular changes that occur during different stages of luteal development and pregnancy can provide insight into the regulation of luteolytic capacity in ruminants.
Article
Agriculture, Dairy & Animal Science
Uxia Yanez, Monica Barrio, Ismael Fernandez, Juan J. Becerra, Pedro G. Herradon, Ana I. Pena, Luis A. Quintela
Summary: The selection of recipients is crucial in embryo transfer programs. This study confirmed the usefulness of rectal palpation and ultrasonography in selecting recipients, while progesterone determination did not provide additional information. The volume of the corpus luteum and the presence of a cavity were also found to be poor indicators of embryo transfer outcome.
Article
Agriculture, Dairy & Animal Science
Cecily Bishop, Vimal Selvaraj, David H. Townson, Joy L. Pate, Milo C. Wiltbank
Summary: The corpus luteum (CL) forms from the cellular remnants of the follicle and produces progesterone required for successful pregnancy. The CL and the embryo have a symbiotic relationship, both relying on each other for survival. The Northeast Multistate Project has contributed to our understanding of the regulation and function of the CL in cattle, providing valuable insights for improving fertility.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Bartlomiej Maria Jaskowski, Hartwig Bostedt, Marek Gehrke, Jedrzej Maria Jaskowski
Summary: The study shows that recipients with a cavitary corpus luteum have higher progesterone levels and pregnancy rates during embryo transfer. Therefore, the presence of a cavity inside the corpus luteum should not be a reason to exclude recipients from embryo transfer.
Article
Reproductive Biology
Megan A. Mezera, Wenli Li, Lihe Liu, Rina Meidan, Francisco Penagaricano, Milo C. Wiltbank
Summary: Research suggests that early subluteolytic PGF pulses impact the luteal transcriptome during natural luteolysis, though not by directly affecting steroidogenesis or inhibiting cellular function. Instead, these early pulses mainly alter pathways related to local steroid and glutathione metabolism.
BIOLOGY OF REPRODUCTION
(2021)
Article
Multidisciplinary Sciences
Yi-Fan Jiang, Pin-Huan Yu, Yovita Permata Budi, Chih-Hsien Chiu, Chi-Yu Fu
Summary: This study investigated the dynamics of mitochondria in mammalian ovaries during folliculogenesis and luteal formation. The results showed that mitochondrial networks shifted from branched structures in follicles to spherical and tubular mitochondria in large luteal cells. Additionally, mitochondrial diameter and volume increased from folliculogenesis to luteal formation, indicating mitochondrial enlargement as an event during these processes. Modulation of mitochondrial morphology and respiratory enzyme expressions may be related to tissue remodeling during luteal formation.
SCIENTIFIC REPORTS
(2021)
Article
Reproductive Biology
Hongwei Duan, Shuai Yang, Longfei Xiao, Shanshan Yang, Zhenxing Yan, Fang Wang, Xiaofei Ma, Lihong Zhang, Yong Zhang, Junjie Hu, Xingxu Zhao
Summary: This study first elucidated the mechanism by which melatonin regulates progesterone secretion in the corpus luteum of sheep, namely by promoting progesterone secretion through the regulation of autophagy. This has important implications for further exploring the role of melatonin in regulating sheep ovarian function.
Article
Food Science & Technology
Dainan Yu, Xun Jiang, Wenjing Ge, Bo Qiao, Dalei Zhang, Hui Liu, Haibin Kuang
Summary: This study found that acrylamide exposure during early- and mid-pregnancy had negative effects on luteal function, including decreased levels of serum progesterone and estradiol, reduced numbers and relative areas of ovarian corpora lutea, dysregulation of ovarian angiogenesis, increased oxidative stress, and induced apoptosis of ovarian cells.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Giuseppina Basini, Simona Bussolati, Simone Bertini, Fausto Quintavalla, Francesca Grasselli
Summary: The study identified that triclosan disrupts cellular function, particularly interfering with hormone production and cell proliferation, suggesting a critical evaluation of its effects.
Article
Agriculture, Dairy & Animal Science
R. S. Bisinotto, E. S. Ribeiro, L. F. Greco, D. Taylor-Rodriguez, A. D. Ealy, H. Ayres, F. S. Lima, N. Martinez, W. W. Thatcher, J. E. P. Santos
Summary: This study evaluated the effects of follicular wave and progesterone concentration on growth of the ovulatory follicle, conceptus elongation, uterine IFN-tau concentration, and transcriptome of conceptus and endometrium in pregnant cows. The results indicated that progesterone concentration had an impact on the growth of ovulatory follicle, but overall had minimal effects on the conceptus and endometrium transcriptome.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Piotr Kaczynski, Monika Baryla, Ewelina Goryszewska, Agnieszka Waclawik
Summary: Intrauterine infusions of E2 can alter the expression of genes involved in CL function, potentially regulating DNA methylation as a physiological mechanism controlling luteal gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Reproductive Biology
Haolin Li, Xiaomeng Pei, Hao Yu, Wei Wang, Dagan Mao
Summary: This study investigated the effects of APN/AdipoRon on autophagy and apoptosis in goat luteal cells, and found that autophagy and apoptosis play important roles in the structural regression of goat corpus luteum.
Article
Agriculture, Dairy & Animal Science
Julia Ribeiro Bevilaqua, Mariana Garcia Kako Rodriguez, Giovanna Serpa Maciel, Gabriel Brun Vergani, Jeferson Ferreira da Fonseca, Pawel Mieczyslaw Bartlewski, Maria Emilia Franco Oliveira
Summary: This study evaluated the effects of different superovulatory doses of porcine follicle-stimulating hormone (pFSH) on luteal morphology and vascularization and assessed if serum progesterone (P-4) measurements and ovarian ultrasonography could be used for early detection of premature regression of corpora lutea (PRCL) in superovulated Santa Ines ewes. The results showed that the total doses of 100 mg and 200 mg of pFSH resulted in similar ovulatory responses and luteal function, but the percentage of donor ewes with normal corpora lutea (nCL) was higher for the 100 mg dose. Serum progesterone concentrations, ultrasonographic estimates of total luteal area, and pixel heterogeneity were identified as potential markers of luteal inadequacy in superovulated ewes.
Article
Reproductive Biology
Tomomi Kanazawa, Motohide Seki, Kosuke Iga
Summary: The present study aimed to evaluate the applicability of corpus luteum (CL) morphology and blood flow for early pregnancy diagnosis in Japanese Black (JB) cattle. The results showed that CL area and CL tissue area were greater in the pregnant group compared to the non-pregnant group on and after Day 19. Blood flow area (BFA) was also greater in the pregnant group on and after Day 18. Logistic regression analysis revealed that BFA on Days 17-20 was the best single predictor for pregnancy diagnosis, while CL area or CL tissue area on Day 21 was the most accurate predictor. BFA and central cavity area (CCA) were identified as effective predictors for early pregnancy diagnosis on Days 18-20.
Article
Agriculture, Dairy & Animal Science
Benjamin R. Crites, Sarah N. Carr, James C. Matthews, Phillip J. Bridges
Summary: Supplementing grazing cattle in selenium-deficient regions with an isomolar 1:1 mix of inorganic and organic selenium can increase early luteal phase progesterone levels, promoting embryonic development. The form of supplemental selenium affects the luteal transcriptome, regulating cholesterol biosynthesis and immune function in the corpus luteum.
JOURNAL OF ANIMAL SCIENCE
(2022)