期刊
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 275, 期 1649, 页码 2389-2392出版社
ROYAL SOC
DOI: 10.1098/rspb.2008.0506
关键词
haemopoiesis; allometry; scaling; stem cells
资金
- Mayo Foundation
- German Research Foundation
- FCT Portugal
Haemopoiesis is a fundamental physiologic process found in many animals. Among mammals, the diversity in size and function required suitable adaptations of this process. In this work, we use allometric principles to determine whether this required a change in the basic architecture of haemopoiesis. We show that it is possible to express both the number and rate with which haemopoietic stem cells replicate as well as total marrow output across all mammals as a function of adult mass. This unified view, which is compatible with the existing data, suggests that there was no need for major adaptations in the architecture of haemopoiesis across mammals.
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