期刊
NATURE COMMUNICATIONS
卷 6, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms6751
关键词
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资金
- Intramural Research Program of the National Institutes of Health, NCI, Division of Cancer Epidemiology and Genetics
- U.S. Public Health Service contracts [N01-CN-45165, N01-RC-45035, N01-RC-37004]
- Canadian Institutes for Health Research (CIHR)
- Canadian Cancer Society, Michael Smith Foundation for Health Research
- The American Cancer Society funds the creation, maintenance and updating of the CPS-II cohort
- National Cancer Institute Surveillance Epidemiology and End Results program
- Leukaemia & Lymphoma Research
- Fondation ARC pour la Recherche sur le Cancer
- Fondation de France
- French Agency for Food, Environmental and Occupational Health Safety (ANSES)
- French National Cancer Institute (INCa)
- Coordinated Action [006438, SP23-CT-2005-006438]
- HuGeF (Human Genetics Foundation), Torino, Italy
- EpiLymph-European Commission [QLK4-CT-2000-00422, FOOD-CT-2006-023103]
- Spanish Ministry of Health [PI11/01810, C03/09, C03/10, RD06/0020/0095]
- Marato de TV3 Foundation [051210]
- Agencia de Gestiod'AjutsUniversitarisi de Recerca-Generalitat de Catalunya [2009SGR1465]
- NIH [NO1-CO-12400]
- Compagnia di San Paolo-Programma Oncologia
- Federal Office for Radiation Protection grants [StSch4261, StSch4420]
- Jose Carreras Leukemia Foundation [DJCLS-R12/23]
- German Federal Ministry for Education and Research [BMBF-01-EO-1303]
- Health Research Board, Ireland
- Cancer Research Ireland
- MH CZ-DRO (MMCI) [00209805]
- RECAMO [CZ.1.05/2.1.00/03.0101]
- Association de Recherche Contre le Cancer
- National Institutes of Health [CA167552, CA97274, R01 CA92153, CA87969, CA49449, CA098122, CA098566, K07 CA115687, 5R01 CA69669-02, RO1CA1046282, RO1CA154643]
- Specialized Programs of Research Excellence (SPORE) in Human Cancer [P50 CA97274]
- Molecular Epidemiology of Non-Hodgkin Lymphoma Survival [R01 CA129539]
- Henry J. Predolin Foundation
- Italian Ministry for Education, University and Research [2007WEJLZB, 20092ZELR2]
- Italian Association for Cancer Research (AIRC) [11855]
- Regional Administration of Sardinia [CRP-59812/2012]
- Fondazione Banco di Sardegna [20102012]
- National Center for Advancing Translational Science [UL1 TR000135]
- VicHealth
- Cancer Council Victoria
- Australian NHMRC [209057, 251553, 504711]
- Geoffrey Beene Cancer Research Grant, Lymphoma Foundation [LF5541]
- Barbara K. Lipman Lymphoma Research Fund [74419]
- Robert and Kate Niehaus Clinical Cancer Genetics Research Initiative [57470, U01 HG007033]
- NCI-SEER-Intramural Research Program of the National Cancer Institute, National Institutes of Health
- Public Health Service [N01-PC-65064, N01-PC-67008, N01-PC-67009, N01-PC-67010, N02-PC-71105]
- Australian National Health and Medical Research Council [ID990920]
- Cancer Council NSW
- University of Sydney Faculty of Medicine
- NYU-WHS-National Cancer Institute [R01 CA098661, P30 CA016087]
- National Institute of Environmental Health Sciences [ES000260]
- Intramural Research Program of the National Cancer Institute
- Division of Cancer Prevention, National Cancer Institute, NIH, DHHS
- Swedish Cancer Society [2009/659]
- Stockholm County Council [20110209]
- Strategic Research Program in Epidemiology at Karolinska Institute
- Swedish Cancer Society grant [02 6661]
- Danish Cancer Research Foundation Grant
- Lundbeck Foundation Grant [R19-A2364]
- Danish Cancer Society Grant [DP 08-155]
- Plan Denmark
- California Department of Health Services
- National Cancer Institute's Surveillance, Epidemiology and End Results Program [HHSN261201000140C, HHSN261201000035C, HHSN261201000034C]
- Centers for Disease Control and Prevention's National Program of Cancer Registries [1U58 DP000807-01]
- National Heart, Lung and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services [HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, HHSN271201100004C]
- National Cancer Institute [CA62006]
- DIVISION OF CANCER CONTROL &POPULATION SCIENCE [N01PC065064, N01PC067009, N01PC067008, N01PC067010] Funding Source: NIH RePORTER
- DIVISION OF CANCER PREVENTION AND CONTROL [N01CN045165] Funding Source: NIH RePORTER
- NATIONAL CANCER INSTITUTE [P30CA016672, P30CA016359, R01CA092153, R01CA149445, U01CA167552, UM1CA182934, R21CA178800, K07CA115687, R01CA154643, P50CA097274, P30CA015083, P30CA016087, P30CA033572, P01CA087969, R01CA062006, R01CA049449, R01CA098661, R01CA129539, U01CA049449, P30CA008748, R25CA098566, ZIACP010170, R01CA098122, UM1CA167552] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR000142, UL1TR000135, UL1TR000430] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR CHRONIC DISEASE PREV AND HEALTH PROMO [U58DP000807] Funding Source: NIH RePORTER
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [U01HG007033] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES000260] Funding Source: NIH RePORTER
Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P - 3.95 x 10(-15)) and HLA-B (rs2922994, P - 2.43 x 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
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