Review
Chemistry, Multidisciplinary
Tingrui Zhang, Zongguang Tai, Zhen Cui, Rongrong Chai, Quangang Zhu, Zhongjian Chen
Summary: Immune cells, with their good biocompatibility and safety, are promising candidates for drug delivery systems, especially in anti-tumor therapy. The methods of loading nanoparticles on immune cells can be divided into backpacks and Trojan horses. However, challenges such as off-target problems and effective release strategies still need to be addressed when using immune cells as cell carriers.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Computer Science, Information Systems
Keyvan Aghababaiyan, Hamed Kebriaei, Vahid Shah-Mansouri, Behrouz Maham, Dusit Niyato
Summary: The novel concept of Internet of Nano Things (IoNT) and Internet of Bio-Nano Things (IoBNT) have opened up new possibilities for IoT applications by connecting nanomachines and biological entities seamlessly. Molecular communication, inspired by biological systems, plays a crucial role in these nanonetworks. By releasing molecules in specific directions, the performance of molecular communication systems can be enhanced.
IEEE INTERNET OF THINGS JOURNAL
(2022)
Article
Computer Science, Information Systems
Lokendra Chouhan, Mohamed-Slim Alouini
Summary: The communication system for health-monitoring applications is a significant research area, and the Internet of Every Nano Things (IoENT) is a potential technology in this field. This work demonstrates the interface between molecular communication (MC) and other nano-communication systems in IoENT, such as human body communication (HBC), acoustic communication (AC), and tera-Hertz (Thz) communication systems. It also highlights the various possibilities and issues related to IoENT applications.
IEEE INTERNET OF THINGS JOURNAL
(2023)
Article
Telecommunications
Mustafa Alper Akkas, Radosveta Sokullu
Summary: This article discusses the potential applications of terahertz and nano-technologies in the Beyond 5G networks, particularly in the healthcare sector. It explores the characteristics of terahertz waves, nano-scale communications, and nano-scale nodes. The article also explores the integration of Internet of Nano Things, molecular communications, and Internet of Bio-Nano Things in healthcare related applications.
WIRELESS PERSONAL COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Wenchang Wei, Yiyi Zhang, Haiqiang Chen, Chuqi Xu, Junwei Zha, Shuangxi Nie
Summary: With the increase in power loads and voltage level, insulating papers face new challenges in their mechanical and electrical properties. However, conventional trial and error experiments are not efficient for preparing cellulose composite insulating paper. To address this issue, nano-SiO2/PI/cellulose composite models were designed and their properties were predicted using molecular dynamics simulation. The results guided the preparation of corresponding insulating paper with nano-SiO2/PI/cellulose, and the surface morphology, mechanical properties, and electrical properties were investigated. The experiment results matched the simulation results, demonstrating the feasibility and effectiveness of using molecular dynamics simulation to guide the development of new insulating papers.
MATERIALS & DESIGN
(2023)
Article
Biochemistry & Molecular Biology
Angelo Felline, Michele Seeber, Francesca Fanelli
Summary: Structure graphs, known as Protein Structure Network (PSN), are cutting-edge tools for investigating macromolecular function. PSNtools is a standalone software that allows calculation and post-processing of PSN analyses. It can perform network comparisons and consensus calculations. Additionally, an updated version of the webPSN server enables interactive graphical analysis of PSN-MD.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Multidisciplinary Sciences
Guillaume Rapin, Nirvana Caballero, Iaroslav Gaponenko, Benedikt Ziegler, Audrey Rawleigh, Ermanno Moriggi, Thierry Giamarchi, Steven A. Brown, Patrycja Paruch
Summary: Cell-cell interactions play a crucial role in both normal tissue development and tumor invasion, affecting the geometry and dynamics of biological interfaces. Pharmacological modulation significantly influences the proliferation speed and roughness evolution of cell fronts. Interactions at different cell length scales exhibit distinct hierarchies of effects on cell front roughness.
SCIENTIFIC REPORTS
(2021)
Review
Engineering, Electrical & Electronic
Xiao-Xia Yin, Alireza Baghai-Wadji, Yanchun Zhang
Summary: Terahertz-band communications are crucial for future healthcare scenarios. Broadband THz sources have high detectability and non-ionization properties. They have great potential for medical diagnostics and treatment technologies, although challenges such as biological safety need to be addressed.
IEEE SENSORS JOURNAL
(2022)
Article
Chemistry, Physical
Luis Estronca, Vitor Francisco, Patricia Pitrez, Ines Honorio, Lara Carvalho, Helena Vazao, Josephine Blersch, Akhilesh Rai, Xavier Nissan, Ulrich Simon, Mario Graos, Leonor Saude, Lino Ferreira
Summary: The study evaluated the vascular bioactivity and safety of 30 different nanoparticle formulations using a zebrafish model and personal humanized models. The results showed that the toxicity profile of the nanoparticles was influenced by the age of endothelial cells and vascular network format, with endothelial cells cultured in flow conditions showing less susceptibility to cytotoxicity effects. The study highlights the importance of in vitro hiPSC-derived vascular systems in screening interactions with vascular nanomaterials.
NANOSCALE HORIZONS
(2021)
Article
Multidisciplinary Sciences
Niall W. Duncan, Russell Shean
Summary: Scientific conferences are increasingly including online aspects, with some becoming entirely virtual and others adopting hybrid models. The development of virtual conference participation has the potential to reduce environmental impact and increase equitable access, but it also raises concerns about the reduction in informal communication between attendees.
Article
Computer Science, Information Systems
Muneer M. Al-Zubi, Ananda S. Mohan, Peter Plapper, Sai Ho Ling
Summary: Molecular communication (MC) is a promising communication paradigm for biomedical applications such as targeted drug delivery and health monitoring systems. Overcoming the blood-tissue barrier (BTB) is a main challenge for MC, and spatiotemporal modeling can help in understanding this process.
IEEE INTERNET OF THINGS JOURNAL
(2022)
Article
Telecommunications
Mustafa Alper Akkas
Summary: The author evaluated the propagation of electromagnetic waves in human tissue, analyzed the propagation characteristics of the Intra-Body Nano-Network communication channel using a theoretical approach, and assessed the single-path and multi-path effects. The research provides guidance for designing nano sensor antennae and utilizing THz range for communication.
WIRELESS PERSONAL COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Romualdo Troisi, Nicole Balasco, Luigi Vitagliano, Filomena Sica
Summary: This study utilized molecular dynamics simulations to investigate the dynamic interactions of thrombin with aptamers TBA and HD22_27mer in binary/ternary complexes, revealing the mechanism of stabilization of these complexes in a crystal-free environment. The dynamics analysis indicated a communication between the exosites in different thrombin binding states, providing insights into the cooperativity of TBA/HD22_27mer binding experimentally detected.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Nanoscience & Nanotechnology
Esme Isik
Summary: The study focuses on nano-scale systems in nano-technology and analyzes the transmission of information via molecules in diffusion medium, highlighting the importance of channel parameters like diffusion constant. It involves obtaining the diffusion constant, developing a new model, predicting medium diffusion constant, and comparing predicted values with simulation results for received molecules. The research explores the impact of environmental parameters on information transfer in nano-scale systems.
Article
Oncology
Kathryn M. Muilenburg, Carly C. Isder, Prakash Radhakrishnan, Surinder K. Batra, Quan P. Ly, Mark A. Carlson, Michael Bouvet, Michael A. Hollingsworth, Aaron M. Mohs
Summary: Pancreatic cancer is difficult to resect completely. Fluorescence-guided surgery (FGS) can help achieve complete tumor resections by using contrast agents that target biomarkers expressed in malignant tissue. Mucins, a family of glycoproteins, are upregulated in pancreatic cancer and have the potential to serve as biomarkers for FGS. This review summarizes the biomarker traits of mucins and their potential use in FGS for pancreatic cancer.
Article
Ecology
Matthew D. Servinsky, Jessica L. Terrell, Chen-Yu Tsao, Hsuan-Chen Wu, David N. Quan, Amin Zargar, Patrick C. Allen, Christopher M. Byrd, Christian J. Sund, William E. Bentley
Article
Biochemical Research Methods
Xiaolong Luo, Chen-Yu Tsao, Hsuan-Chen Wu, David N. Quan, Gregory F. Payne, Gary W. Rubloff, William E. Bentley
Article
Chemistry, Multidisciplinary
Yuan-Chia Kuo, Hsuan-Chen Wu, Dao Hoang, William E. Bentley, Warren D. D'Souza, Srinivasa R. Raghavan
Article
Biotechnology & Applied Microbiology
Amin Zargar, David N. Quan, Milad Emamian, Chen Yu Tsao, Hsuan-Chen Wu, Chelsea R. Virgile, William E. Bentley
METABOLIC ENGINEERING
(2015)
Article
Materials Science, Biomaterials
Yi Liu, Hsuan-Chen Wu, Melanie Chhuan, Jessica L. Terrell, Chen-Yu Tsao, William E. Bentley, Gregory F. Payne
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2015)
Article
Materials Science, Biomaterials
Yi Liu, Hsuan-Chen Wu, Melanie Chhuan, Jessica L. Terrell, Chen-Yu Tsao, William E. Bentley, Gregory F. Payne
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2015)
Article
Biotechnology & Applied Microbiology
Hsuan-Chen Wu, David N. Quan, Chen-Yu Tsao, Yi Liu, Jessica L. Terrell, Xiaolong Luo, Jen-Chang Yang, Gregory F. Payne, William E. Bentley
BIOTECHNOLOGY AND BIOENGINEERING
(2017)
Article
Biochemical Research Methods
David N. Quan, Chen-Yu Tsao, Hsuan-Chen Wu, William E. Bentley
PLOS COMPUTATIONAL BIOLOGY
(2016)
Article
Multidisciplinary Sciences
Tanya Tschirhart, Eunkyoung Kim, Ryan McKay, Hana Ueda, Hsuan-Chen Wu, Alex Eli Pottash, Amin Zargar, Alejandro Negrete, Joseph Shiloach, Gregory F. Payne, William E. Bentley
NATURE COMMUNICATIONS
(2017)
Article
Polymer Science
Chun-Yu Chen, Szu Ying Huang, Hung-Yu Wan, Yi-Ting Chen, Sheng-Ka Yu, Hsuan-Chen Wu, Ta- Yang
Article
Materials Science, Biomaterials
Shan-Ru Wu, Jheng-Liang Chen, Hsuan-Chen Wu
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2020)
Article
Nanoscience & Nanotechnology
Jessica L. Terrell, Tanya Tschirhart, Justin P. Jahnke, Kristina Stephens, Yi Liu, Hong Dong, Margaret M. Hurley, Maria Pozo, Ryan McKay, Chen Yu Tsao, Hsuan-Chen Wu, Gary Vora, Gregory F. Payne, Dimitra N. Stratis-Cullum, William E. Bentley
Summary: Living electrodes facilitate signaling within microbial communities, coordinating behavior. This study developed a bioelectronic communication system that allows exchange of information between living cells and an engineered microbial network, enabling real-time control and feedback. The system demonstrates how molecular communication can be propagated to drive biological signal propagation and programmed tasks concurrently.
NATURE NANOTECHNOLOGY
(2021)
Article
Biochemical Research Methods
Jui-Chung Hong, Hao-Chun Fan, Po-Jiun Yang, Da-Wei Lin, Hsuan-Chen Wu, Hsiao-Chun Huang
Summary: The study shows that localized proteolysis can be employed to construct intracellular asymmetry in Escherichia coli, providing a new strategy for polarization in developmental cell biology. Circuits designed in this study may help to expand the synthetic biology repository for the engineering of synthetic morphogenesis.
ACS SYNTHETIC BIOLOGY
(2021)
Article
Polymer Science
Shin-Da Wu, Wei-Tsung Chuang, Jo-Chen Ho, Hsuan-Chen Wu, Shan-hui Hsu
Summary: Biomimetic recombinant spider silk with self-healing properties was fabricated using genetic engineering. The self-assembled recombinant spider silk hydrogel exhibited autonomous self-healing and high strain-sensitive properties, which were attributed to the stick-slip behavior of the 8-sheet nanocrystals. In addition, the recombinant spider silk as a dry coating material demonstrated self-healing under humidity and showed good affinity towards neural stem cells.