Review
Biochemistry & Molecular Biology
Khouloud Ayed, Lamis Nabi, Rym Akrout, Hela Mrizak, Amal Gorrab, Dhouha Bacha, Hamouda Boussen, Asma Gati
Summary: Obesity has become a global epidemic in recent decades and is associated with an increased risk of cancer. The mechanisms underlying the obesity-cancer connection are not fully understood, but adipokines, particularly leptin, may play a critical role. This review summarizes the current literature on the involvement of leptin in tumorigenesis, its effects on the immune response, its impact on anti-cancer treatments, and its potential as a target for cancer prevention and treatment.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Laura Bergantini, Miriana d'Alessandro, Sara Gangi, Francesco Bianchi, Paolo Cameli, Beatrice Perea, Martina Meocci, Gaia Fabbri, Sofia Marrucci, Moftah Ederbali, Elena Bargagli
Summary: Coronavirus disease 2019 (COVID-19) may lead to a chronic syndrome in some patients even after the infection is resolved. Persistent cytokine dysregulation can cause long-lasting inflammation and tissue damage, resulting in a variety of debilitating symptoms. This study evaluated the value of serum biomarkers in predicting severity, prognosis, and development of post-COVID lung sequelae.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Prachi Wele, Xian Wu, Haifei Shi
Summary: Colorectal cancer is the third most common cancer globally, with the second highest cancer-related mortality. Obesity has been identified as one of the contributing factors to the increase in colorectal cancer, but the mechanistic link between obesity, sex hormones, and colorectal cancer development is not well understood.
Review
Biochemistry & Molecular Biology
Lisa Wrba, Rebecca Halbgebauer, Julian Roos, Markus Huber-Lang, Pamela Fischer-Posovszky
Summary: Despite efforts to improve patient outcomes, trauma remains a significant issue in clinical practice and society, particularly among younger individuals. Adipose tissue plays an essential role in regulating the posttraumatic inflammatory response, both through its secretory products and as an immune target of injured remote organs.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Sebastian Dommel, Matthias Bluher
Summary: Obesity is associated with adipose tissue dysfunction, leading to metabolic inflammation and increased immune cell infiltration, with CCL2 playing a crucial role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Hui Qian, Xiaojuan Chao, Shaogui Wang, Yuan Li, Xiaoxiao Jiang, Zhaoli Sun, Thomas Ruelicke, Kurt Zatloukal, Hong-Min Ni, Wen -Xing Ding
Summary: Loss of SQSTM1/p62 leads to adipose tissue dysfunction and mature-onset obesity in mice. Loss of SQSTM1/p62 leads to brown adipose tissue maladaptation to alcohol consumption resulting in more severe liver injury.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Oncology
Ibrahim AlZaim, Aya Al-Saidi, Safaa H. Hammoud, Nadine Darwiche, Yusra Al-Dhaheri, Ali H. Eid, Ahmed F. El-Yazbi
Summary: As overweight and obesity increase, the number of individuals diagnosed with prostate cancer also rises. The increase in fat tissue can lead to inflammation, which may increase the aggressiveness of prostate cancer. The production of blood clotting factors is also increased in obesity, fat tissue inflammation, and prostate cancer. This article explores the role of these clotting factors in the progression of prostate cancer due to increased body weight and proposes new treatment approaches.
Review
Oncology
Guido Eibl, Enrique Rozengurt
Summary: Obesity is recognized as a chronic progressive disease and a risk factor for diseases like pancreatic cancer. The link between obesity and pancreatic cancer may involve pathways related to adipose tissue and adipose tissue inflammation. Therefore, preventive and interceptive strategies targeting obesity-associated adipose tissue inflammation could help attenuate the promoting effects of obesity on pancreatic cancer development.
Article
Biochemistry & Molecular Biology
Stephan Wueest, Eleonora Seelig, Katharina Timper, Mark P. Lyngbaek, Kristian Karstoft, Marc Y. Donath, Helga Ellingsgaard, Daniel Konrad
Summary: Blocking IL-6 receptor increases circulating adiponectin levels and decreases leptin levels in obese individuals, positively impacting insulin sensitivity.
Article
Oncology
Nazli Bahrami, Shakila Jabeen, Andliena Tahiri, Torill Sauer, Hilde Presterud Odegard, Stephanie Beate Geisler, Berit Gravdehaug, Laurens Cornelus Reitsma, Knut Selsas, Vessela Kristensen, Jurgen Geisler
Summary: The study found that exemestane treatment significantly decreased serum levels of leptin, while letrozole caused a slight increase in leptin levels, providing new insights into the lack of cross-resistance between non-steroidal and steroidal aromatase inhibitors in breast cancer patients.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Review
Pharmacology & Pharmacy
Mei Yu, Mengxian Ju, Penghua Fang, Zhenwen Zhang
Summary: Consumption of a high calorie diet with irregular eating and sedentary behavior habits is typical of the current suboptimal lifestyle, contributing to the development of metabolic diseases such as obesity and type 2 diabetes mellitus. The adipokines spexin and leptin play important roles in regulating adipogenesis and glucose metabolism. Their levels and interaction in patients with obesity and diabetes also affect the development of these diseases.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Neurosciences
Cheng-Chun Liu, Qing-Hua Wang, Jia-Yan Xin, Yu-Hao Liu, Fan Zeng, Dong-Wan Chen, Hui-Yun Li, Xu Yi, Gui-Hua Zeng, Yan-Jiang Wang, Yang Xiang, Yang Chen
Summary: This study investigated the associations between adiponectin, leptin, and resistin levels and Alzheimer's Disease (AD). The results showed that plasma adiponectin and leptin levels were associated with the presence, symptomatic severity, and diagnostic power of AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Carlos Jimenez-Cortegana, German Ortiz-Garcia, Amalia Serrano, David Moreno-Ramirez, Victor Sanchez-Margalet
Summary: Atopic dermatitis is a common and complex chronic inflammatory skin disease, with increasing incidence in developed countries in recent years. Obesity, a global health issue on the rise, has been associated with diseases like atopic dermatitis. Research suggests that leptin, an important adipokine, may play a key role in the pathogenesis of atopic dermatitis.
Review
Physiology
Micael Deivison de Jesus Alves, Devisson dos Santos Silva, Erika Vitoria Moura Pereira, Danielle Dutra Pereira, Matheus Santos de Sousa Fernandes, Dayane Franciely Conceicao Santos, Davi Pereira Monte Oliveira, Lucio Marques Vieira-Souza, Felipe J. Aidar, Raphael Fabricio de Souza
Summary: Long-distance running leads to increased inflammation, particularly in IL-6 levels. The impact of running distance on inflammatory response is not significant. Besides IL-6, other cytokines also show changes in concentration. Prolonged aerobic exercise provides protection against chronic systemic inflammation. Variability in running volume modulates compounds involved in homeostasis and cell signaling.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Annamaria Schaffer, Eszter Ducza, Nikolett Bodi, Maria Bagyanszki, Zita Szalai, Mohsen Mirdamadi, Tamara Barna, Kalman F. Szucs, Robert Gaspar
Summary: Leptin and adiponectin play a role in the relaxation of the pregnant uterus, but their efficacy decreases towards the end of gestation. The endometrial receptors have a fine-tuning role in uterine contractions, indicating the importance of these adipokines under altered adipokine level conditions.