期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 115, 期 42, 页码 E9981-E9990出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1803003115
关键词
visual word recognition; visual word form area; functional and structural MRI; reading; quantitative MRI
资金
- European Molecular Biology Organization (EMBO) [158-2015]
- Marie Sklodowska-Curie [H2020-MSCA-IF-2017-795807-ReCiModel]
- Spanish Ministry of Economy and Competitiveness (MINECO) [PSI2015-67353-R, SEV-2015-0490]
- European Research Council (ERC) [ERC-2011-ADG-295362]
- MINECO [SEV-2015-0490, RYC-2014-15440, PSI2012-32093]
- Departamento de Desarrollo Economico y Competitividad, Gobierno Vasco grants [PI2016-12]
The ventral occipitotemporal cortex (vOTC) is crucial for recognizing visual patterns, and previous evidence suggests that there may be different subregions within the vOTC involved in the rapid identification of word forms. Here, we characterize vOTC reading circuitry using a multimodal approach combining functional, structural, and quantitative MRI and behavioral data. Two main wordresponsive vOTC areas emerged: a posterior area involved in visual feature extraction, structurally connected to the intraparietal sulcus via the vertical occipital fasciculus; and an anterior area involved in integrating information with other regions of the language network, structurally connected to the angular gyrus via the posterior arcuate fasciculus. Furthermore, functional activation in these vOTC regions predicted reading behavior outside of the scanner. Differences in the microarchitectonic properties of gray-matter cells in these segregated areas were also observed, in line with earlier cytoarchitectonic evidence. These findings advance our understanding of the vOTC circuitry by linking functional responses to anatomical structure, revealing the pathways of distinct reading-related processes.
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