Potentiating KCC2 activity is sufficient to limit the onset and severity of seizures

Role of KCC2-dependent potassium efflux in 4-Aminopyridine-induced Epileptiform synchronization

(2018) Oscar C. González et al.   NEUROBIOLOGY OF DISEASE

Locally Reducing KCC2 Activity in the Hippocampus is Sufficient to Induce Temporal Lobe Epilepsy

(2018) Matt R. Kelley et al.   EBioMedicine

N-Ethylmaleimide increases KCC2 cotransporter activity by modulating transporter phosphorylation

(2017) Leslie C. Conway et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The small molecule CLP257 does not modify activity of the K+–Cl− co-transporter KCC2 but does potentiate GABAA receptor activity

(2017) Ross A Cardarelli et al.   NATURE MEDICINE

Simultaneous two-photon imaging of intracellular chloride concentration and pH in mouse pyramidal neurons in vivo

(2017) Sebastian Sulis Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Seizing Control of KCC2: A New Therapeutic Target for Epilepsy

(2017) Yvonne E. Moore et al.   TRENDS IN NEUROSCIENCES

Compromising KCC2 transporter activity enhances the development of continuous seizure activity

(2016) Matthew R. Kelley et al.   NEUROPHARMACOLOGY

Cl-out is a novel cooperative optogenetic tool for extruding chloride from neurons

(2016) Hannah Alfonsa et al.   Nature Communications

Impaired neuronal KCC2 function by biallelic SLC12A5 mutations in migrating focal seizures and severe developmental delay

(2016) Hirotomo Saitsu et al.   Scientific Reports

Enhanced expression of potassium-chloride cotransporter KCC2 in human temporal lobe epilepsy

(2015) Mária R. Karlócai et al.   Brain Structure & Function

Selective Inhibition of KCC2 Leads to Hyperexcitability and Epileptiform Discharges in Hippocampal Slices and In Vivo

(2015) S. Sivakumaran et al.   JOURNAL OF NEUROSCIENCE

The Contribution of Raised Intraneuronal Chloride to Epileptic Network Activity

(2015) H. Alfonsa et al.   JOURNAL OF NEUROSCIENCE

KCC2 function modulates in vitro ictogenesis

(2015) Shabnam Hamidi et al.   NEUROBIOLOGY OF DISEASE

Could tuning of the inhibitory tone involve graded changes in neuronal chloride transport?

(2015) Stefan Titz et al.   NEUROPHARMACOLOGY

KCC2 activity is critical in limiting the onset and severity of status epilepticus

(2015) Liliya Silayeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons

(2015) Perrine Friedel et al.   Science Signaling

Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures

(2015) Tommy Stödberg et al.   Nature Communications

WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons

(2015) Perrine Friedel et al.   Science Signaling

Molecular Mechanism Underlying the Plant NRT1.1 Dual-Affinity Nitrate Transporter

(2015) Ji Sun et al.   Frontiers in Physiology

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+–Cl−co-transporters

(2014) Paola de los Heros et al.   BIOCHEMICAL JOURNAL

GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy

(2014) Susan L. Campbell et al.   GLIA

Molecular Motions Involved in Na-K-Cl Cotransporter-mediated Ion Transport and Transporter Activation Revealed by Internal Cross-linking between Transmembrane Domains 10 and 11/12

(2014) Michelle Y. Monette et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Excitatory Effects of Parvalbumin-Expressing Interneurons Maintain Hippocampal Epileptiform Activity via Synchronous Afterdischarges

(2014) T. J. Ellender et al.   JOURNAL OF NEUROSCIENCE

Disrupted Cl−homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited states

(2013) Tarek Z. Deeb et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Taurine Inhibits K+-Cl−Cotransporter KCC2 to Regulate Embryonic Cl−Homeostasis via With-no-lysine (WNK) Protein Kinase Signaling Pathway

(2012) Koichi Inoue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity-Dependent Cleavage of the K-Cl Cotransporter KCC2 Mediated by Calcium-Activated Protease Calpain

(2012) M. Puskarjov et al.   JOURNAL OF NEUROSCIENCE

Adverse effects of antiepileptic drugs

(2012) Piero Perucca et al.   LANCET NEUROLOGY

Pyramidal cells accumulate chloride at seizure onset

(2012) Kyle P. Lillis et al.   NEUROBIOLOGY OF DISEASE

The K+-Cl−cotransporter KCC2 promotes GABAergic excitation in the mature rat hippocampus

(2010) Tero Viitanen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity

(2009) Jesse Rinehart et al.   CELL

Fast activity at seizure onset is mediated by inhibitory circuits in the entorhinal cortex in vitro

(2008) Vadym Gnatkovsky et al.   ANNALS OF NEUROLOGY