Two novel proteinO-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling

Biological functions of fucose in mammals

(2017) Michael Schneider et al.   GLYCOBIOLOGY

O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking

(2017) Hideyuki Takeuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recognition of EGF-like domains by the Notch-modifying O-fucosyltransferase POFUT1

(2017) Zhijie Li et al.   Nature Chemical Biology

Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity

(2017) Vincent C. Luca et al.   SCIENCE

Structural basis of Notch O-glucosylation and O–xylosylation by mammalian protein–O-glucosyltransferase 1 (POGLUT1)

(2017) Zhijie Li et al.   Nature Communications

Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations

(2016) Hongjun Yu et al.   Nature Chemical Biology

Notch signalling in context

(2016) Sarah J. Bray   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ST8SIA4-Dependent Polysialylation is Part of a Developmental Program Required for Germ Layer Formation from Human Pluripotent Stem Cells

(2016) Ryan P. Berger et al.   STEM CELLS

Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies

(2016) Philip C. Weisshuhn et al.   STRUCTURE

Structural basis for Notch1 engagement of Delta-like 4

(2015) V. C. Luca et al.   SCIENCE

Significance of glycosylation in Notch signaling

(2014) Hideyuki Takeuchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands

(2014) P. Taylor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrinsic Selectivity of Notch 1 for Delta-like 4 Over Delta-like 1

(2013) Marie Blanke Andrawes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1

(2012) Yuta Sakaidani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Site-specificO-Glucosylation of the Epidermal Growth Factor-like (EGF) Repeats of Notch

(2012) Hideyuki Takeuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch signaling in human development and disease

(2012) Andrea L. Penton et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Fringe benefits: Functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptors

(2011) Nadia A Rana et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi

(2011) R. Fernandez-Valdivia et al.   DEVELOPMENT

O-Glucose Trisaccharide Is Present at High but Variable Stoichiometry at Multiple Sites on Mouse Notch1

(2011) Nadia A. Rana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase

(2011) H. Takeuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

O-Linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell–matrix interactions

(2011) Yuta Sakaidani et al.   Nature Communications

Role of glycans and glycosyltransferases in the regulation of Notch signaling

(2010) H. Jafar-Nejad et al.   GLYCOBIOLOGY

Role of glycosylation of Notch in development

(2010) Hideyuki Takeuchi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling

(2008) Melih Acar et al.   CELL