期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 111, 期 52, 页码 18727-18732出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1417017112
关键词
memory; intracranial EEG; oscillations; reinstatement
资金
- National Institute of Neurological Disorders and Stroke
- National Institutes of Health [MH055687, MH061975, NS067316, MH017168]
- National Science Foundation (NSF) [1055560]
- Burroughs Wellcome Fund Career Award at the Scientific Interface [1007274]
- NSF Graduate Research Fellowship Program (GRFP) [DGE-1232825]
- Achievement Rewards for College Scientists (ARCS) Foundation
- Epilepsy Foundation Pre-doctoral Research Training Fellowship
Reinstatement of neural activity is hypothesized to underlie our ability to mentally travel back in time to recover the context of a previous experience. We used intracranial recordings to directly examine the precise spatiotemporal extent of neural reinstatement as 32 participants with electrodes placed for seizure monitoring performed a paired-associates episodic verbal memory task. By cueing recall, we were able to compare reinstatement during correct and incorrect trials, and found that successful retrieval occurs with reinstatement of a gradually changing neural signal present during encoding. We examined reinstatement in individual frequency bands and individual electrodes and found that neural reinstatement was largely mediated by temporal lobe theta and high-gamma frequencies. Leveraging the high temporal precision afforded by intracranial recordings, our data demonstrate that high-gamma activity associated with reinstatement preceded theta activity during encoding, but during retrieval this difference in timing between frequency bands was absent. Our results build upon previous studies to provide direct evidence that successful retrieval involves the reinstatement of a temporal context, and that such reinstatement occurs with precise spatiotemporal dynamics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据