Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis

Phosphorylation of substrates destined for secretion by the Fam20 kinases

(2013) Vincent S. Tagliabracci et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Exome sequencing reveals FAM20c mutations associated with fibroblast growth factor 23-related hypophosphatemia, dental anomalies, and ectopic calcification

(2013) Silje Hjorth Rafaelsen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Crystal structure of the Golgi casein kinase

(2013) J. Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Cellular regulation by protein phosphorylation

(2012) Edmond H. Fischer   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Site-specific protein O-glycosylation modulates proprotein processing — Deciphering specific functions of the large polypeptide GalNAc-transferase gene family

(2012) Katrine T.-B.G. Schjoldager et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mechanism of FGF23 processing in fibrous dysplasia

(2012) Nisan Bhattacharyya et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The Raine Syndrome Protein FAM20C Is a Golgi Kinase That Phosphorylates Bio-Mineralization Proteins

(2012) Hiroyuki O. Ishikawa et al.   PLoS One

Secreted Kinase Phosphorylates Extracellular Proteins That Regulate Biomineralization

(2012) V. S. Tagliabracci et al.   SCIENCE

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Secreted protein kinases

(2012) Vincent S. Tagliabracci et al.   TRENDS IN BIOCHEMICAL SCIENCES

Fibroblast growth factor 23: state of the field and future directions

(2012) Nisan Bhattacharyya et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Amelogenesis Imperfecta and Other Biomineralization Defects in Fam20a and Fam20c Null Mice

(2012) P. Vogel et al.   VETERINARY PATHOLOGY

Inactivation of a Novel FGF23 Regulator, FAM20C, Leads to Hypophosphatemic Rickets in Mice

(2012) Xiaofang Wang et al.   PLoS Genetics

Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease

(2011) Gerald W. Hart et al.   Annual Review of Biochemistry

The expanding family of hypophosphatemic syndromes

(2011) Thomas O. Carpenter   JOURNAL OF BONE AND MINERAL METABOLISM

Iron Modifies Plasma FGF23 Differently in Autosomal Dominant Hypophosphatemic Rickets and Healthy Humans

(2011) Erik A. Imel et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice

(2011) E. G. Farrow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss-of-Function ENPP1 Mutations Cause Both Generalized Arterial Calcification of Infancy and Autosomal-Recessive Hypophosphatemic Rickets

(2010) Bettina Lorenz-Depiereux et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Regulation of Phosphate Homeostasis by PTH, Vitamin D, and FGF23

(2010) Clemens Bergwitz et al.   Annual Review of Medicine

Iron-Sensing Proteins that Regulate Hepcidin and Enteric Iron Absorption

(2010) Mitchell D. Knutson   Annual Review of Nutrition

Golgi apparatus casein kinase phosphorylates bioactive Ser-6 of bone morphogenetic protein 15 and growth and differentiation factor 9

(2010) Elena Tibaldi et al.   FEBS LETTERS

Expression of FAM20C in the Osteogenesis and Odontogenesis of Mouse

(2010) Xiaofang Wang et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Motif Analysis of Phosphosites Discloses a Potential Prominent Role of the Golgi Casein Kinase (GCK) in the Generation of Human Plasma Phospho-Proteome

(2010) Mauro Salvi et al.   JOURNAL OF PROTEOME RESEARCH

Recent advances in renal phosphate handling

(2010) Emily G. Farrow et al.   Nature Reviews Nephrology

Location, location, location: new insights into O-GalNAc protein glycosylation

(2010) David J. Gill et al.   TRENDS IN CELL BIOLOGY

Mutations in FAM20C also identified in non-lethal osteosclerotic bone dysplasia

(2009) MA Simpson et al.   CLINICAL GENETICS

Defective O-Glycosylation due to a Novel Homozygous S129P Mutation Is Associated with Lack of Fibroblast Growth Factor 23 Secretion and Tumoral Calcinosis

(2009) Clemens Bergwitz et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

An Initial Characterization of the Serum Phosphoproteome

(2009) Weidong Zhou et al.   JOURNAL OF PROTEOME RESEARCH

Characterization of the Human Cerebrospinal Fluid Phosphoproteome by Titanium Dioxide Affinity Chromatography and Mass Spectrometry

(2008) Justyna Maria Czarna Bahl et al.   ANALYTICAL CHEMISTRY

Phosphorylated Proteins and Control over Apatite Nucleation, Crystal Growth, and Inhibition

(2008) Anne George et al.   CHEMICAL REVIEWS

Characterization of the post-translational modification of recombinant human BMP-15 mature protein

(2008) Seiji Saito et al.   PROTEIN SCIENCE