Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore

Structural Basis for Antibody Recognition in the Receptor-binding Domains of Toxins A and B fromClostridium difficile

(2013) Tomohiko Murase et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Segment of 97 Amino Acids within the Translocation Domain of Clostridium difficile Toxin B Is Essential for Toxicity

(2013) Yongrong Zhang et al.   PLoS One

Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex

(2013) M. A. Farrow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Determinants ofClostridium difficileToxin A Glucosyltransferase Activity

(2012) Rory N. Pruitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clostridium difficile Toxin B Causes Epithelial Cell Necrosis through an Autoprocessing-Independent Mechanism

(2012) Nicole M. Chumbler et al.   PLoS Pathogens

Structural determinants for membrane insertion, pore formation and translocation of Clostridium difficile toxin B

(2011) Selda Genisyuerek et al.   MOLECULAR MICROBIOLOGY

The Repetitive Oligopeptide Sequences Modulate Cytopathic Potency but Are Not Crucial for Cellular Uptake of Clostridium difficile Toxin A

(2011) Alexandra Olling et al.   PLoS One

Autoproteolytic cleavage mediates cytotoxicity of Clostridium difficile toxin A

(2010) Isa Kreimeyer et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Clostridial Glucosylating Toxins Enter Cells via Clathrin-Mediated Endocytosis

(2010) Panagiotis Papatheodorou et al.   PLoS One

Roles of Glu 349 and Asp 352 in membrane insertion and translocation by diphtheria toxin

(2010) Poonam Kaul et al.   PROTEIN SCIENCE

Variations in TcdB Activity and the Hypervirulence of Emerging Strains of Clostridium difficile

(2010) Jordi M. Lanis et al.   PLoS Pathogens

The Membrane Topography of the Diphtheria Toxin T Domain Linked to the A Chain Reveals a Transient Transmembrane Hairpin and Potential Translocation Mechanisms

(2009) Jie Wang et al.   BIOCHEMISTRY

Membrane translocation by anthrax toxin

(2009) R. John Collier   MOLECULAR ASPECTS OF MEDICINE

Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium

(2008) Guilin Yang et al.   BMC MICROBIOLOGY

Conformational Changes and Reaction of Clostridial Glycosylating Toxins

(2008) Mathias O.P. Ziegler et al.   JOURNAL OF MOLECULAR BIOLOGY

Clostridium difficile— More Difficult Than Ever

(2008) Ciarán P. Kelly et al.   NEW ENGLAND JOURNAL OF MEDICINE