Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression

ERKs in Cancer: Friends or Foes?

(2014) Xavier Deschênes-Simard et al.   CANCER RESEARCH

Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis

(2014) Manuel Valiente et al.   CELL

EGR1 decreases the malignancy of human non-small cell lung carcinoma by regulating KRT18 expression

(2014) Huihua Zhang et al.   Scientific Reports

Tumor cell-expressed SerpinB2 is present on microparticles and inhibits metastasis

(2014) Wayne A. Schroder et al.   Cancer Medicine

Down-Regulation of Dual-Specificity Phosphatase 5 in Gastric Cancer by Promoter CpG Island Hypermethylation and Its Potential Role in Carcinogenesis

(2013) So-Hyun Shin et al.   AMERICAN JOURNAL OF PATHOLOGY

Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation

(2013) X. Deschenes-Simard et al.   GENES & DEVELOPMENT

Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance

(2013) Meghna Das Thakur et al.   NATURE

The Transcription Factor C/EBP-β Mediates Constitutive and LPS-Inducible Transcription of Murine SerpinB2

(2013) Ekemini A. Udofa et al.   PLoS One

TLR-induced PAI-2 expression suppresses IL-1  processing via increasing autophagy and NLRP3 degradation

(2013) S.-Y. Chuang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual-specificity MAP kinase phosphatases (MKPs)

(2012) Christopher J. Caunt et al.   FEBS Journal

Identification of Mutant K-Ras-dependent Phenotypes Using a Panel of Isogenic Cell Lines

(2012) Steffan Vartanian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis

(2012) Thomas Jamieson et al.   JOURNAL OF CLINICAL INVESTIGATION

EGR1 and the ERK-ERF axis drive mammary cell migration in response to EGF

(2011) Gabi Tarcic et al.   FASEB JOURNAL

Ink4a/Arf and Oncogene-Induced Senescence Prevent Tumor Progression during Alternative Colorectal Tumorigenesis

(2010) Moritz Bennecke et al.   CANCER CELL

Human papilloma virus transformed CaSki cells constitutively express high levels of functional SerpinB2

(2010) Lee Major et al.   EXPERIMENTAL CELL RESEARCH

RAS Mutations Affect Tumor Necrosis Factor-Induced Apoptosis in Colon Carcinoma Cells via ERK-Modulatory Negative and Positive Feedback Circuits Along with Non-ERK Pathway Effects

(2009) P. K. Kreeger et al.   CANCER RESEARCH

Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK

(2009) Anna Kucharska et al.   CELLULAR SIGNALLING

Multi-stage chemical carcinogenesis in mouse skin: Fundamentals and applications

(2009) Erika L Abel et al.   Nature Protocols

Identification of direct transcriptional targets ofV600EBRAF/MEK signalling in melanoma

(2009) Leisl M Packer et al.   Pigment Cell & Melanoma Research

V600EBRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway

(2009) C. A. Pratilas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide investigation of in vivo EGR-1 binding sites in monocytic differentiation

(2009) Atsutaka Kubosaki et al.   GENOME BIOLOGY

Dual-specificity MAP kinase phosphatases (MKPs) and cancer

(2008) Stephen M. Keyse   CANCER AND METASTASIS REVIEWS

SerpinB2 Protection of Retinoblastoma Protein from Calpain Enhances Tumor Cell Survival

(2008) L. Tonnetti et al.   CANCER RESEARCH

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

(2008) Kevin M Haigis et al.   NATURE GENETICS