Article
Biochemistry & Molecular Biology
Koushiro Fujimoto, Kentaro Nakano, Hidekazu Kuwayama, Shigehiko Yumura
Summary: The study demonstrates that GmfA plays a crucial role in cell migration, with its absence leading to changes in cell morphology and motility characteristics.
Article
Biochemistry & Molecular Biology
Ana Filipa Sobral, Fung-Yi Chan, Michael J. Norman, Daniel S. Osorio, Ana Beatriz Dias, Vanessa Ferreira, Daniel J. Barbosa, Dhanya Cheerambathur, Reto Gassmann, Julio Monti Belmonte, Ana Xavier Carvalho
Summary: The study demonstrates a synergy between the small rigid crosslinker plastin and the large flexible crosslinker spectrin in the C. elegans embryo, showing that their combined action stabilizes the actomyosin network in cytokinesis. Co-inhibition of plastin and beta H-spectrin results in cytokinesis failure, highlighting the importance of crosslinker interplay for network integrity.
Article
Biochemistry & Molecular Biology
Brittni A. Scruggs, Huber Martins Vasconcelos Jr, Mariana Matioli da Palma, Katie Kogachi, Mark E. Pennesi, Paul Yang, Steven T. Bailey, Andreas K. Lauer
Summary: This study characterized the intraoperative pressure levels for subretinal gene therapy delivery across eight retinal conditions and found that patient age affects the maximum injection pressures required for bleb propagation, with the relationship varying based on retinal condition. These findings have important implications for optimizing surgical protocols for subretinal injections.
Article
Psychology, Multidisciplinary
Thi Tuan Linh Pham, Tzu-Ling Huang, Gen-Yih Liao, Yu-Jen Chou, T. C. E. Cheng, Ching- Teng
Summary: Online games are global computer applications where gamers form teams to achieve gaming goals. Lack of in-game cooperation knowledge may make it difficult for gamers to integrate into gaming groups, thereby reducing their loyalty towards online games. However, there is limited understanding of how in-game cooperation knowledge influences gamer loyalty, creating a research gap. We used social capital theory to develop a model and collected data from 3036 online gamers. Our findings show that cooperation knowledge, team participation experience, and gaming community identification positively impact online gamer loyalty. Additionally, cooperation knowledge strengthens the relationship between team participation experience and loyalty, providing valuable insights for game providers.
COMPUTERS IN HUMAN BEHAVIOR
(2023)
Article
Genetics & Heredity
Wladyslaw A. Krajewski
Summary: Tight packaging of DNA in chromatin restricts DNA accessibility and dynamics, while studying the inherent dynamics and interactions of nucleosomes is crucial for understanding their functionality and diversifying epigenetic programming methods.
FRONTIERS IN GENETICS
(2022)
Article
Cardiac & Cardiovascular Systems
Ku-Chi Tsao, Yuh-Charn Lin, Yi-Ting Chen, Shih-Lei Lai, Ruey-Bing Yang
Summary: This study demonstrates the critical cooperation between SCUBE1 and SCUBE2 in regulating angiogenic cell behaviors and the formation of functional vessels during zebrafish embryonic development.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biology
Daria S. Morozova, Alexey A. Martyanov, Sergei Obydennyi, Julia-Jessica D. Korobkin, Alexey Sokolov, Ekaterina Shamova, Irina Gorudko, Anna L. Khoreva, Anna Shcherbina, Mikhail A. Panteleev, Anastasia N. Sveshnikova
Summary: In this study, an ex vivo experimental model for observation of granulocyte activity in thrombus formation was developed. Results showed that granulocytes from patients with WAS had reduced motility compared to healthy donors. The study suggests that WASP deficiency disrupts granulocyte behavior in thromboinflammatory conditions.
Article
Management
Minyue Jin, Gendao Li, Marc Reimann
Summary: This paper examines the impact of authorization on cooperation between OEMs and IRs, as well as the different elements of authorization strategies. The study finds that whether cooperation is achieved depends on the effect of authorization on customers' willingness to pay for remanufactured products, and environmental and social impact is also an important factor to consider in cooperation.
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
(2022)
Article
Immunology
Tamar Kapanadze, Jaba Gamrekelashvili, Stefan Sablotny, Dustin Kijas, Hermann Haller, Kai Schmidt-Ott, Florian P. Limbourg
Summary: Ischemia induces an inflammatory response involving monocyte-derived macrophages (MF) that contribute to angiogenesis and tissue repair. Notch signaling, mediated by Notch ligand Delta-like 1 (Dll1), plays a role in regulating angiogenesis and ischemic macrophage differentiation. Colony stimulating factor 1 (CSF-1) is essential for MF lineage development, but its interaction with Notch signaling in ischemic macrophage development is not well understood.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Xuehua Xu, Miao Pan, Tian Jin
Summary: The discovery of how phagocytes effectively find and kill pathogens through chemotaxis and phagocytosis sheds light on the evolutionarily conserved mechanisms underlying these processes in mammals.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Catherine Fleitas, Pau Marfull-Oromi, Disha Chauhan, Daniel del Toro, Blanca Peguera, Bahira Zammou, Daniel Rocandio, Rudiger Klein, Carme Espinet, Joaquim Egea
Summary: Neuron migration is important in nervous system development, with FLRTs controlling the distribution of cortical inhibitory interneurons through Unc5 receptors, potentially impacting the development of psychiatric disorders.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biology
Ines Lahmann, Joscha Griger, Jie-Shin Chen, Yao Zhang, Markus Schuelke, Carmen Birchmeier
Summary: MET and CXCR4 cooperate to protect muscle stem cells against the harsh inflammatory environment encountered in acute muscle injury. Lack of these factors leads to severe apoptosis in early stages of regeneration.
Article
Multidisciplinary Sciences
Farshad Babaeijandaghi, Adrianna Paiero, Reece Long, Lin Wei Tung, Shannon Percival Smith, Ryan Cheng, Joshua Smandych, Nasim Kajabadi, Chih-Kai Chang, Amirhossein Ghassemi, William D. M. Kennedy, Hesham Soliman, Peter W. Schutz, Fabio M. Rossi
Summary: In this study, it is found that natural killer (NK) cells are the main source of IFN gamma in regenerating muscle. The production of IFN gamma is also limited to a small population of T cells. However, NK cells do not play a major role in muscle regeneration. The absence of IFN gamma per se has no effect on muscle regeneration, but its role is partially unmasked when TNF alpha is also neutralized.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Cell Biology
Jan Schick, Erez Raz
Summary: In the context of cell development, migration, and pathological conditions, cells commonly form protrusions called blebs. The inflation of blebs depends on actomyosin contraction, and they play an important role in cell locomotion. Different cells produce different forms of protrusions, with blebs being one of them.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Carolina M. Polonio, Patrick da Silva, Fabiele B. Russo, Brendo R. N. Hyppolito, Nagela G. Zanluqui, Cecilia Benazzato, Patricia C. B. Beltrao-Braga, Sandra M. Muxel, Jean Pierre S. Peron
Summary: Viral infections, particularly Zika virus, have a significant impact on public health, causing severe fetal neuropathogenesis and microcephaly. MiRNAs play a role in infected neuronal precursor cells and directly contribute to the pathogenesis of fetal microcephaly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biology
Jason S. King, Robert R. Kay
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2019)
Article
Multidisciplinary Sciences
Nishit Srivastava, David Traynor, Matthieu Piel, Alexandre J. Kabla, Robert R. Kay
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Review
Genetics & Heredity
Evgeny Zatulovskiy, Jan M. Skotheim
TRENDS IN GENETICS
(2020)
Review
Biochemistry & Molecular Biology
Bjorn Stinner, Till Bretschneider
BIOCHEMICAL SOCIETY TRANSACTIONS
(2020)
Article
Computer Science, Interdisciplinary Applications
E. Josiah Lutton, Sharon Collier, Till Bretschneider
Summary: This work focuses on detailed 3D segmentation of Dictyostelium cells using high-resolution 3D microscopy, proposing a novel random walker-based method with a curvature enhancement term. Experimental results demonstrate the method's superior performance in segmentation of 3D images, accurately capturing cell features, and also introducing an automated seeding method to facilitate the process.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Article
Biochemistry & Molecular Biology
Michael C. Lanz, Evgeny Zatulovskiy, Matthew P. Swaffer, Lichao Zhang, Ilayda Ilerten, Shuyuan Zhang, Dong Shin You, Georgi Marinov, Patrick McAlpine, Joshua E. Elias, Jan M. Skotheim
Summary: Cell size influences various aspects of cell physiology, including cellular senescence. Increasing cell size leads to changes in protein concentration, specifically those associated with senescence. Larger cells are more prone to senescence, but this is not observed when cell size increase is accompanied by an increase in ploidy.
Article
Biology
Tamao Saito, Tomoyuki Iijima, Kohei Koyama, Tomonori Shinagawa, Ayaka Yamanaka, Tsuyoshi Araki, Noriyuki Suzuki, Toyonobu Usuki, Robert R. Kay
Summary: The soil is a complex ecosystem where various ecological interactions occur. Dictyostelium discoideum, a social amoeba with a high genomic potential, produces polyketides to regulate these interactions. This study reveals that D. discoideum utilizes specific enzymes to produce chlorinated signal molecules and antibacterial polyketides. These compounds play a role in protecting mature spores from bacterial infection.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Shuyuan Zhang, Evgeny Zatulovskiy, Julia Arand, Julien Sage, Jan M. M. Skotheim
Summary: Every type of cell in an animal maintains a specific size, and the RB-dilution mechanism plays a role in controlling cell size by linking cell growth to the G1/S transition, as demonstrated in the mouse liver.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Evgeny Zatulovskiy, Michael C. C. Lanz, Shuyuan Zhang, Frank McCarthy, Joshua E. E. Elias, Jan M. M. Skotheim
Summary: Increasing cell size affects the proteome and cell physiology. Cell size and growth rate are interdependent and they remodel the proteome in similar ways. The effects of cell size on proteome composition may be primarily due to changes in the cell's growth rate.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Editorial Material
Cell Biology
Jette Lengefeld, Evgeny Zatulovskiy
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemical Research Methods
Adam Platt, E. Josiah Lutton, Edward Offord, Till Bretschneider
Summary: Advances in 3D live cell microscopy have made it possible to capture previously unobserved processes with high-resolution. However, utilizing modern machine learning methods to fully benefit from these technologies is hindered by the difficulty of manually annotating 3D training data. MiCellAnnGELo virtual reality software provides an immersive environment for viewing and interacting with 4D microscopy data, including efficient annotation tools. This software offers a wide range of applications, such as labeling cell surfaces for cell motility, endocytosis, and transmembrane signaling.
Meeting Abstract
Cell Biology
E. Zatulovskiy, M. Lanz, S. Zhang, J. Elias, J. Skotheim
MOLECULAR BIOLOGY OF THE CELL
(2023)
Meeting Abstract
Cell Biology
S. Zhang, E. Zatulovskiy, L. F. Valenzuela, J. Skotheim
MOLECULAR BIOLOGY OF THE CELL
(2023)
Article
Multidisciplinary Sciences
Evgeny Zatulovskiy, Shuyuan Zhang, Daniel F. Berenson, Benjamin R. Topacio, Jan M. Skotheim
Article
Developmental Biology
Robert R. Kay, Thomas D. Williams, James D. Manton, David Traynor, Peggy Paschke
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
(2019)