Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery

Diagnostic discrepancies in malignant astrocytoma due to limited small pathological tumor sample can be overcome by IDH1 testing

(2014) Betty Y. S. Kim et al.   JOURNAL OF NEURO-ONCOLOGY

Molecular assessment of surgical-resection margins of gastric cancer by mass-spectrometric imaging

(2014) L. S. Eberlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

(2013) J.-A. Losman et al.   GENES & DEVELOPMENT

Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate

(2013) Ovidiu C. Andronesi et al.   JOURNAL OF CLINICAL INVESTIGATION

Mass spectrometry imaging as a tool for surgical decision-making

(2013) David Calligaris et al.   JOURNAL OF MASS SPECTROMETRY

The impact of extent of resection on malignant transformation of pure oligodendrogliomas

(2013) Laura A. Snyder et al.   JOURNAL OF NEUROSURGERY

IDH/MGMT-driven molecular classification of low-grade glioma is a strong predictor for long-term survival

(2013) S. Leu et al.   NEURO-ONCOLOGY

IDH1 mutant malignant astrocytomas are more amenable to surgical resection and have a survival benefit associated with maximal surgical resection

(2013) Jason Beiko et al.   NEURO-ONCOLOGY

Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors

(2013) L. S. Eberlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

(2013) J.-A. Losman et al.   SCIENCE

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

(2013) D. Rohle et al.   SCIENCE

Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation

(2013) F. Wang et al.   SCIENCE

Prospective, high-throughput molecular profiling of human gliomas

(2012) Andrew S. Chi et al.   JOURNAL OF NEURO-ONCOLOGY

Morbidity profile following aggressive resection of parietal lobe gliomas

(2012) Nader Sanai et al.   JOURNAL OF NEUROSURGERY

IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2012) Chao Lu et al.   NATURE

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

(2012) Peppi Koivunen et al.   NATURE

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas

(2012) Changho Choi et al.   NATURE MEDICINE

Ambient mass spectrometry for in vivo local analysis and in situ molecular tissue imaging

(2012) Peter Nemes et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Biological Tissue Diagnostics Using Needle Biopsy and Spray Ionization Mass Spectrometry

(2011) Jiangjiang Liu et al.   ANALYTICAL CHEMISTRY

Ambient Sampling/Ionization Mass Spectrometry: Applications and Current Trends

(2011) Glenn A. Harris et al.   ANALYTICAL CHEMISTRY

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Classifying Human Brain Tumors by Lipid Imaging with Mass Spectrometry

(2011) L. S. Eberlin et al.   CANCER RESEARCH

Nondestructive, Histologically Compatible Tissue Imaging by Desorption Electrospray Ionization Mass Spectrometry

(2011) Livia S. Eberlin et al.   CHEMBIOCHEM

Isocitrate dehydrogenase mutations: A challenge to traditional views on the genesis and malignant progression of gliomas

(2011) Michael Weller et al.   GLIA

Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy

(2011) Whitney B. Pope et al.   JOURNAL OF NEURO-ONCOLOGY

An extent of resection threshold for newly diagnosed glioblastomas

(2011) Nader Sanai et al.   JOURNAL OF NEUROSURGERY

IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

(2011) M Fernanda Amary et al.   JOURNAL OF PATHOLOGY

Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping

(2011) D. R. Borger et al.   ONCOLOGIST

BRAF V600E Mutations Are Common in Pleomorphic Xanthoastrocytoma: Diagnostic and Therapeutic Implications

(2011) Dora Dias-Santagata et al.   PLoS One

Desorption electrospray ionization and other ambient ionization methods: current progress and preview

(2010) Demian R. Ifa et al.   ANALYST

Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine

(2010) Dora Dias-Santagata et al.   EMBO Molecular Medicine

The genetic basis of kidney cancer: a metabolic disease

(2010) W. Marston Linehan et al.   Nature Reviews Urology

Intraoperative Real-Time Querying of White Matter Tracts During Frameless Stereotactic Neuronavigation

(2010) Haytham Elhawary et al.   NEUROSURGERY

Development of Stereotactic Mass Spectrometry for Brain Tumor Surgery

(2010) Nathalie Y.R. Agar et al.   NEUROSURGERY

Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas

(2009) Christian Hartmann et al.   ACTA NEUROPATHOLOGICA

Characterization of R132H Mutation-specific IDH1 Antibody Binding in Brain Tumors

(2009) David Capper et al.   BRAIN PATHOLOGY

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

(2009) Elaine R. Mardis et al.   NEW ENGLAND JOURNAL OF MEDICINE

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of Extent of Resection in the Long-Term Outcome of Low-Grade Hemispheric Gliomas

(2008) Justin S. Smith et al.   JOURNAL OF CLINICAL ONCOLOGY

Established and emerging atmospheric pressure surface sampling/ionization techniques for mass spectrometry

(2008) Gary J. Van Berkel et al.   JOURNAL OF MASS SPECTROMETRY

Ambient molecular imaging by desorption electrospray ionization mass spectrometry

(2008) Justin M Wiseman et al.   Nature Protocols

GLIOMA EXTENT OF RESECTION AND ITS IMPACT ON PATIENT OUTCOME

(2008) Nader Sanai et al.   NEUROSURGERY

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE