Article
Biochemistry & Molecular Biology
Emmelie Eckhardt, Max Bastian
Summary: The CD1 antigen presenting system is evolutionarily conserved and can be found in mammals, birds, and reptiles. Research on the role of CD1a, CD1b, and CD1c in mice has been hindered by their lack of expression in mice, but alternative animal models have provided valuable insights into CD1-dependent antimicrobial immune functions. Transgenic mouse models have also contributed to a better understanding of the mechanisms involved in CD1-restricted T cell responses.
MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Aparajita Saha, Jaclyn Escudero, Troy Layouni, Barbra Richardson, Sharon Hou, Nelly Mugo, Andrew Mujugira, Connie Celum, Jared M. Baeten, Jairam Lingappa, Grace C. John-Stewart, Sylvia M. LaCourse, Javeed A. Shah
Summary: This study found that immune activation changes during pregnancy and postpartum may contribute to increased risk for tuberculosis progression. Specifically, pregnant women with latent tuberculosis infection showed diminished M. tuberculosis-specific CD4(+) cytokine responses in the third trimester, while M. tuberculosis-specific CD8(+) cytokines and nonspecifically activated T-cells increased during late pregnancy.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Julia Y. Kam, Elinor Hortle, Elizabeth Krogman, Sherridan E. Warner, Kathryn Wright, Kaiming Luo, Tina Cheng, Pradeep Manuneedhi Cholan, Kazu Kikuchi, James A. Triccas, Warwick J. Britton, Matt D. Johansen, Laurent Kremer, Stefan H. Oehlers
Summary: This study investigates the differences in immunopathogenesis induced by R and S variants of M. abscessus using an adult zebrafish model.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Hye-Soo Park, Seunga Choi, Yong-Woo Back, Kang-In Lee, Han-Gyu Choi, Hwa-Jung Kim
Summary: The study found that PGE2 produced by RpfE-activated dendritic cells via the MAPK and cyclooxygenase 2 signaling pathways induces Th1 and Th17 cell responses mainly via the EP4 receptor, contributing to defense against Mycobacterium tuberculosis infection. Moreover, adding optimal amount of PGE2 to IL-2-IL-6-IL-23p19-IL-1 beta is essential for promoting differentiation into Th1/Th17 cells with strong bactericidal activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Alex J. Warr, Christine Anterasian, Javeed A. Shah, Stephen C. De Rosa, Felicia K. Nguyen, Elizabeth Maleche-Obimbo, Lisa M. Cranmer, Daniel Matemo, Jerphason Mecha, John Kinuthia, Sylvia M. LaCourse, Grace C. John-Stewart, Thomas R. Hawn
Summary: This study investigates the relationship between immune cell responses after BCG vaccination and Mycobacterium tuberculosis (Mtb) infection in HIV-exposed but uninfected infants, as well as their impact on tuberculin skin test (TST) induration. The results show that a monofunctional TNF+ CD4+ effector memory T-cell response at 6-10 weeks of age is associated with Mtb infection at 14 months, while mycobacterial antigen-specific polyfunctional effector memory Th1 responses at 6-10 weeks correlate positively with TST induration in infants without evidence of Mtb infection, which is attenuated by INH therapy.
Article
Immunology
Ahmed Esmael, Tamrat Abebe, Adane Mihret, Daniel Mussa, Sebsib Neway, Joel Ernst, Jyothi Rengarajan, Liya Wassie, Rawleigh Howe
Summary: This study investigated the discriminatory role of polychromatic flow cytometry of M. tuberculosis antigen-specific T cells in distinguishing smear-negative TB from health controls and non-TB respiratory illnesses. The results showed that PPD-specific T cells expressing activation/proliferation markers and cytokines were significantly higher in patients with smear-positive and smear-negative pulmonary TB compared to healthy controls and patients with non-TB illness.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Immunology
Jess A. Millar, J. Russell Butler, Stephanie Evans, Joshua T. Mattila, Jennifer J. Linderman, JoAnne L. Flynn, Denise E. Kirschner
Summary: Tuberculosis is a global health issue, and understanding the immune response to Mycobacterium tuberculosis infection is crucial for successful interventions. Research suggests that the structural organization of lung granulomas and recruitment of non-specific T cells may contribute to reduced T cell responsiveness in TB infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xueting Fan, Xiaoyan Li, Kanglin Wan, Xiuqin Zhao, Yunli Deng, Zixin Chen, Xiuli Luan, Shuangshuang Lu, Haican Liu
Summary: This study cloned the genes of the immunodominant antigen of M. tuberculosis and evaluated the immunity and immunogenicity of PstS1 and PstS1p. The results indicate that PstS1p is highly immunogenic in mice and may be a promising candidate vaccine for controlling tuberculosis.
Article
Genetics & Heredity
Kristina Ritter, Jochen Behrends, Hanna Erdmann, Jasmin Rousseau, Alexandra Hoelscher, Johanna Volz, Immo Prinz, Thomas Lindenstrom, Christoph Hoelscher
Summary: IL-23 plays a key role in early protection against Mtb infection after vaccination, while IL-17A does not mediate this protection in the short term, but has an impact on long-term protection.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Immunology
Cheleka A. M. Mpande, Pia Steigler, Tessa Lloyd, Virginie Rozot, Boitumelo Mosito, Constance Schreuder, Timothy D. Reid, Nicole Bilek, Morten Ruhwald, Jason R. Andrews, Mark Hatherill, Francesca Little, Thomas J. Scriba, Elisa Nemes
Summary: This study investigated the association between QuantiFERON-TB Gold (QFT) reversion and decline of M.tb-specific functional T cell responses. The findings suggest that individuals with QFT reversion exhibit lower M.tb-specific T cell responses, potentially due to assay variability or well-controlled M.tb infection in some cases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Yolanda M. Jacobo-Delgado, Adrian Rodriguez-Carlos, Carmen J. Serrano, Bruno Rivas-Santiago
Summary: Mycobacterium tuberculosis is a major infectious agent causing millions of deaths each year, and its drug resistance has become a significant issue. Antimicrobial peptides have shown effectiveness against multidrug-resistant bacteria, but their efficiency against Mycobacterium tuberculosis remains uncertain due to the complexity of its cell wall.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Ana B. Enriquez, Angelo Izzo, Shannon M. Miller, Erica L. Stewart, Robert N. Mahon, Daniel J. Frank, Jay T. Evans, Jyothi Rengarajan, James A. Triccas
Summary: Tuberculosis remains a leading cause of death worldwide, with recent advancements in vaccine research showing potential for more effective vaccines in the future. More research and development are needed to improve TB vaccine efficacy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Cheleka A. M. Mpande, Virginie Rozot, Boitumelo Mosito, Munyaradzi Musvosvi, One B. Dintwe, Nicole Bilek, Mark Hatherill, Thomas J. Scriba, Elisa Nemes
Summary: Recent M.tb infection is associated with highly activated and moderately differentiated functional M.tb-specific T cell subsets, which can be used as biomarkers to distinguish recent from remote infection. This study provides new insights into the immunobiology of M.tb infection and potential diagnostic tools.
Article
Immunology
Sofya A. Kust, Maria A. Streltsova, Alexander V. Panteleev, Natalya L. Karpina, Irina V. Lyadova, Alexander M. Sapozhnikov, Elena I. Kovalenko
Summary: NK cells expressing HLA-DR play a critical role in the control of tuberculosis infection by exhibiting higher proliferative activity and increased expression of NK receptors. These cells show higher IFN-γ production and degranulation level in response to mycobacteria stimulation, serving as an important link to the adaptive immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Samantha Donnellan, Shaun H. Pennington, Alessandra Ruggiero, Carmen Martinez-Rodriguez, Marion Pouget, Jordan Thomas, Steve A. Ward, Georgios Pollakis, Giancarlo A. Biagini, William A. Paxton
Summary: The coinfection of tuberculosis and HIV is a major global health concern. This study used fluorescent labeled viral particles and bacteria to investigate the pathogenesis and treatment of coinfection. It was found that HIV infection inhibited the replication of tuberculosis, and antiviral and antimicrobial treatments showed therapeutic efficacy. This method can be used for mechanistic studies to develop novel treatment strategies.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Elvire A. Bourgeois, Sumithra Subramaniam, Tan-Yun Cheng, Annemieke De Jong, Emilie Layre, Dalam Ly, Maryam Salimi, Annaliza Legaspi, Robert L. Modlin, Mariolina Salio, Vincenzo Cerundolo, D. Branch Moody, Graham Ogg
JOURNAL OF EXPERIMENTAL MEDICINE
(2015)
Article
Immunology
Sobhan Roy, Dalam Ly, Caitlin D. Castro, Nan-Sheng Li, Andrew J. Hawk, John D. Altman, Stephen C. Meredith, Joseph A. Piccirilli, D. Branch Moody, Erin J. Adams
JOURNAL OF IMMUNOLOGY
(2016)
Article
Oncology
Dalam Ly, Chang-Qi Zhu, Michael Cabanero, Ming-Sound Tsao, Li Zhang
CANCER IMMUNOLOGY RESEARCH
(2017)
Review
Immunology
Si-si Wang, Wei Liu, Dalam Ly, Hao Xu, Limei Qu, Li Zhang
CELLULAR & MOLECULAR IMMUNOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Dalam Ly, D. Branch Moody
CELLULAR AND MOLECULAR LIFE SCIENCES
(2014)
Article
Immunology
P. Achita, D. Dervovic, D. Ly, J. B. Lee, T. Haug, B. Joe, N. Hirano, L. Zhang
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2018)
Article
Immunology
Dalam Ly, Anne G. Kasmar, Tan-Yun Cheng, Annemieke de Jong, Shouxiong Huang, Sobhan Roy, Apoorva Bhatt, Ruben P. van Summeren, John D. Altman, William R. Jacobs, Erin J. Adams, Adriaan J. Minnaard, Steven A. Porcelli, Branch Moody
JOURNAL OF EXPERIMENTAL MEDICINE
(2013)
Article
Oncology
Junlin Yao, Dalam Ly, Dzana Dervovic, Linan Fang, Jong Bok Lee, Hyeonjeong Kang, Yu-Hui Wang, Nhu-An Pham, Hongming Pan, Ming-Sound Tsao, Li Zhang
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2019)
Article
Oncology
Dennis Wang, Nhu-An Pham, Timothy M. Freeman, Vibha Raghavan, Roya Navab, Jonathan Chang, Chang-Qi Zhu, Dalam Ly, Jiefei Tong, Bradly G. Wouters, Melania Pintilie, Michael F. Moran, Geoffrey Liu, Frances A. Shepherd, Ming-Sound Tsao
Article
Biology
Kenji Murata, Munehide Nakatsugawa, Muhammed A. Rahman, Linh T. Nguyen, Douglas G. Millar, David T. Mulder, Kenji Sugata, Hiroshi Saijo, Yukiko Matsunaga, Yuki Kagoya, Tingxi Guo, Mark Anczurowski, Chung-Hsi Wang, Brian D. Burt, Dalam Ly, Kayoko Saso, Alexandra Easson, David P. Goldstein, Michael Reedijk, Danny Ghazarian, Trevor J. Pugh, Marcus O. Butler, Tak W. Mak, Pamela S. Ohashi, Naoto Hirano
Article
Hematology
Fraser Soares, Branson Chen, Jong Bok Lee, Musaddeque Ahmed, Dalam Ly, Enoch Tin, Hyeonjeong Kang, Yong Zeng, Nayeema Akhtar, Mark D. Minden, Housheng Hansen He, Li Zhang
Summary: AMl remains a devastating disease for which new therapies are needed. Targeted adoptive T-cell therapies have shown promise in some leukemias but not in AML. A study utilizing CRISPR/Cas9 screens identified SAGA and CD64 as key factors influencing the sensitivity of AML cells to DNT therapy.
Article
Biotechnology & Applied Microbiology
Kenji Sugata, Yukiko Matsunaga, Yuki Yamashita, Munehide Nakatsugawa, Tingxi Guo, Levon Halabelian, Yota Ohashi, Kayoko Saso, Muhammed A. Rahman, Mark Anczurowski, Chung-Hsi Wang, Kenji Murata, Hiroshi Saijo, Yuki Kagoya, Dalam Ly, Brian D. Burt, Marcus O. Butler, Tak W. Mak, Naoto Hirano
Summary: By combining molecular biological and immunological techniques, this study successfully cloned sequences encoding HLA-DP, HLA-DQ, and HLA-DR molecules with enhanced CD4 binding affinity and produced affinity-matured class II dimers that stain antigen-specific T cells better than conventional multimers. These affinity-matured class II dimers will aid in the investigation of human CD4(+) T-cell responses, providing a comprehensive library of dimers for HLA-DP, HLA-DQ, and HLA-DR alleles. The readily detectable CD4(+) T cells with class II MHC dimers are crucial for studying human immune responses.
NATURE BIOTECHNOLOGY
(2021)
Article
Oncology
Dalam Ly, Quan Li, Roya Navab, Cedric Zeltz, Linan Fang, Michael Cabanero, Chang-Qi Zhu, Ming-Sound Tsao, Li Zhang
Summary: Understanding how the immune system regulates the tumor microenvironment is crucial for the development of effective cancer treatments. This study reveals the adverse prognostic role of LAIR2 expression in regulatory T cells and identifies it as a potential target for future immunotherapies.
Article
Oncology
JongBok Lee, Mark D. Minden, Weihsu C. Chen, Elena Streck, Branson Chen, Hyeonjeong Kang, Andrea Arruda, Dalam Ly, Sandy D. Der, Sohyeong Kang, Paulina Achita, Cheryl D'Souza, Yueyang Li, Richard W. Childs, John E. Dick, Li Zhang
CLINICAL CANCER RESEARCH
(2018)