标题
Defining functional DNA elements in the human genome
作者
关键词
-
出版物
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 111, Issue 17, Pages 6131-6138
出版商
Proceedings of the National Academy of Sciences
发表日期
2014-04-22
DOI
10.1073/pnas.1318948111
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
- (2013) F. Ann Ran et al. CELL
- Identifying Recent Adaptations in Large-Scale Genomic Data
- (2013) Sharon R. Grossman et al. CELL
- The ENCODE project: Missteps overshadowing a success
- (2013) Sean R. Eddy CURRENT BIOLOGY
- On the Immortality of Television Sets: "Function" in the Human Genome According to the Evolution-Free Gospel of ENCODE
- (2013) D. Graur et al. Genome Biology and Evolution
- Genome-Level Analysis of Selective Constraint without Apparent Sequence Conservation
- (2013) Olga A. Vakhrusheva et al. Genome Biology and Evolution
- Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay
- (2013) P. Kheradpour et al. GENOME RESEARCH
- Gene expression drives local adaptation in humans
- (2013) H. B. Fraser GENOME RESEARCH
- Characterizing the genetic basis of transcriptome diversity through RNA-sequencing of 922 individuals
- (2013) A. Battle et al. GENOME RESEARCH
- Exaptation of Transposable Elements into Novel Cis-Regulatory Elements: Is the Evidence Always Strong?
- (2013) F. S. J. de Souza et al. MOLECULAR BIOLOGY AND EVOLUTION
- Is junk DNA bunk? A critique of ENCODE
- (2013) W. F. Doolittle PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Comment on "Evidence of Abundant Purifying Selection in Humans for Recently Acquired Regulatory Functions"
- (2013) P. Green et al. SCIENCE
- Genome Regulation by Long Noncoding RNAs
- (2012) John L. Rinn et al. Annual Review of Biochemistry
- Revisiting Global Gene Expression Analysis
- (2012) Jakob Lovén et al. CELL
- The C-value paradox, junk DNA and ENCODE
- (2012) Sean R. Eddy CURRENT BIOLOGY
- Small RNA in the nucleus: the RNA-chromatin ping-pong
- (2012) Ivan Olovnikov et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Rates and Fitness Consequences of New Mutations in Humans
- (2012) Peter D. Keightley GENETICS
- Linking disease associations with regulatory information in the human genome
- (2012) M. A. Schaub et al. GENOME RESEARCH
- DNase I sensitivity QTLs are a major determinant of human expression variation
- (2012) Jacob F. Degner et al. NATURE
- Landscape of transcription in human cells
- (2012) Sarah Djebali et al. NATURE
- The genomic basis of adaptive evolution in threespine sticklebacks
- (2012) Felicity C. Jones et al. NATURE
- Architecture of the human regulatory network derived from ENCODE data
- (2012) Mark B. Gerstein et al. NATURE
- Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay
- (2012) Alexandre Melnikov et al. NATURE BIOTECHNOLOGY
- Massively parallel functional dissection of mammalian enhancers in vivo
- (2012) Rupali P Patwardhan et al. NATURE BIOTECHNOLOGY
- Revising the human mutation rate: implications for understanding human evolution
- (2012) Aylwyn Scally et al. NATURE REVIEWS GENETICS
- Evidence of Abundant Purifying Selection in Humans for Recently Acquired Regulatory Functions
- (2012) L. D. Ward et al. SCIENCE
- Systematic Localization of Common Disease-Associated Variation in Regulatory DNA
- (2012) M. T. Maurano et al. SCIENCE
- A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes
- (2012) D. G. MacArthur et al. SCIENCE
- Systematic Dissection of Roles for Chromatin Regulators in a Yeast Stress Response
- (2012) Assaf Weiner et al. PLOS BIOLOGY
- Characterization of the single-cell transcriptional landscape by highly multiplex RNA-seq
- (2011) S. Islam et al. GENOME RESEARCH
- What fraction of the human genome is functional?
- (2011) C. P. Ponting et al. GENOME RESEARCH
- A high-resolution map of human evolutionary constraint using 29 mammals
- (2011) Kerstin Lindblad-Toh et al. NATURE
- Mapping and analysis of chromatin state dynamics in nine human cell types
- (2011) Jason Ernst et al. NATURE
- A Functional Element Necessary for Fetal Hemoglobin Silencing
- (2011) Vijay G. Sankaran et al. NEW ENGLAND JOURNAL OF MEDICINE
- HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants
- (2011) L. D. Ward et al. NUCLEIC ACIDS RESEARCH
- Three Periods of Regulatory Innovation During Vertebrate Evolution
- (2011) C. B. Lowe et al. SCIENCE
- Histone modification: cause or cog?
- (2011) Steven Henikoff et al. TRENDS IN GENETICS
- The Reality of Pervasive Transcription
- (2011) Michael B. Clark et al. PLOS BIOLOGY
- Natural Selection Affects Multiple Aspects of Genetic Variation at Putatively Neutral Sites across the Human Genome
- (2011) Kirk E. Lohmueller et al. PLoS Genetics
- Genomics of Long-Range Regulatory Elements
- (2010) James P. Noonan et al. Annual Review of Genomics and Human Genetics
- Transcriptional silencing of -globin by BCL11A involves long-range interactions and cooperation with SOX6
- (2010) J. Xu et al. GENES & DEVELOPMENT
- Massive turnover of functional sequence in human and other mammalian genomes
- (2010) S. Meader et al. GENOME RESEARCH
- Transcriptome genetics using second generation sequencing in a Caucasian population
- (2010) Stephen B. Montgomery et al. NATURE
- A unique chromatin signature uncovers early developmental enhancers in humans
- (2010) Alvaro Rada-Iglesias et al. NATURE
- Understanding mechanisms underlying human gene expression variation with RNA sequencing
- (2010) Joseph K. Pickrell et al. NATURE
- Histone H3K27ac separates active from poised enhancers and predicts developmental state
- (2010) M. P. Creyghton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identifying a High Fraction of the Human Genome to be under Selective Constraint Using GERP++
- (2010) Eugene V. Davydov et al. PLoS Computational Biology
- MicroRNAs: Target Recognition and Regulatory Functions
- (2009) David P. Bartel CELL
- Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression
- (2009) Y. Cheng et al. GENOME RESEARCH
- ChIP-seq accurately predicts tissue-specific activity of enhancers
- (2009) Axel Visel et al. NATURE
- Genome engineering
- (2009) Peter A Carr et al. NATURE BIOTECHNOLOGY
- Global mapping of protein-DNA interactions in vivo by digital genomic footprinting
- (2009) Jay R Hesselberth et al. NATURE METHODS
- The complex eukaryotic transcriptome: unexpected pervasive transcription and novel small RNAs
- (2009) Alain Jacquier NATURE REVIEWS GENETICS
- Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
- (2009) L. A. Hindorff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Local DNA Topography Correlates with Functional Noncoding Regions of the Human Genome
- (2009) S. C. J. Parker et al. SCIENCE
- Adaptive Evolution of Pelvic Reduction in Sticklebacks by Recurrent Deletion of a Pitx1 Enhancer
- (2009) Y. F. Chan et al. SCIENCE
- Common Regulatory Variation Impacts Gene Expression in a Cell Type-Dependent Manner
- (2009) A. S. Dimas et al. SCIENCE
- The Evolution of Gene Regulation Underlies a Morphological Difference between Two Drosophila Sister Species
- (2008) Sangyun Jeong et al. CELL
- Evo-Devo and an Expanding Evolutionary Synthesis: A Genetic Theory of Morphological Evolution
- (2008) Sean B. Carroll CELL
- Chromatin structure analyses identify miRNA promoters
- (2008) F. Ozsolak et al. GENES & DEVELOPMENT
- Mapping and quantifying mammalian transcriptomes by RNA-Seq
- (2008) Ali Mortazavi et al. NATURE METHODS
- Tools for neuroanatomy and neurogenetics in Drosophila
- (2008) B. D. Pfeiffer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metrics of sequence constraint overlook regulatory sequences in an exhaustive analysis at phox2b
- (2007) D. M. McGaughey et al. GENOME RESEARCH
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