Review
Biochemistry & Molecular Biology
Silvia Santana-Sosa, Emiliano Matos-Perdomo, Jessel Ayra-Plasencia, Felix Machin
Summary: The morphology of the nucleus is typically spherical in eukaryotic cells, but it can change during cell migration and division. This is important because abnormal nuclear morphology is associated with cancer and aging, and targeting nuclear shaping pathways and proteins can be used in therapies. Recent evidence also suggests a connection between nuclear shape and lysosomal function in tumor cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Yanying Wu, Yue Chang, Liming Luo, Wenqi Tian, Qingqiu Gong, Xinqi Liu
Summary: The study reveals the important role of NRP in plant growth, promoting the degradation of PIN2 to maintain its concentration and polarity, thereby facilitating primary root elongation. ABA can employ this pathway to inhibit root elongation for stress adaptation.
Article
Biochemistry & Molecular Biology
Wei Dong, Xubo Zhang, Yue Kong, Zhenwen Zhao, Ali Mahmoud, Lixian Wu, Bernard Moussian, Jianzhen Zhang
Summary: The study demonstrates that the midgut-specific CYP311A1 in fruit flies plays a crucial role in lipid distribution by shaping microvilli in a PE-dependent manner.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Plant Sciences
Xiuxiu Zhang, Hui Li, Hai Lu, Inhwan Hwang
Summary: This article summarizes the two types of vacuoles in plant cells and the recent progress in studying their protein trafficking mechanisms, discusses the commonalities and specificities between lytic vacuoles and protein storage vacuoles, as well as the interconnection provided by the protein trafficking machinery between these organelles.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Chemistry, Multidisciplinary
Qishuai Feng, Wenming Fang, Yuedong Guo, Ping Hu, Jianlin Shi
Summary: Cancer stem cells (CSCs) play a critical role in the initiation and progression of early lung cancer. By modulating the communication between tumor-associated macrophages (TAMs) and CSCs, we developed a nebulized therapeutic strategy that triggers CSC ferroptosis, leading to the suppression of early lung cancer.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Antonia Piazzesi, Yiru Wang, Joshua Jackson, Lena Wischhof, Viktoria Zeisler-Diehl, Enzo Scifo, Ina Oganezova, Thorben Hoffmann, Pablo Gomez Martin, Fabio Bertan, Chester J. J. Wrobel, Frank C. Schroeder, Dan Ehninger, Kristian Haendler, Joachim L. Schultze, Lukas Schreiber, Gerhild Van Echten-Deckert, Pierluigi Nicotera, Daniele Bano
Summary: Mitochondrial dysfunction can be influenced by enhanced metabolic flexibility, which can extend the lifespan of mitochondrial mutants. CEST-2.2, a carboxylesterase mainly localized in the intestine, has been found to stimulate the survival of mitochondrial deficient animals. Through transcriptome and lipidome analysis, it has been shown that CEST-2.2 promotes lipid metabolism and fatty acid beta-oxidation, enhancing the respiratory capacity of mitochondria and extending the lifespan of mutant nematodes.
Editorial Material
Biology
Rebecca Martina Fausten, Maria Bohnert
Summary: When a yeast cell runs out of fuel, it can boost the flux through a central metabolic pathway simply by relocating an enzyme.
Review
Plant Sciences
Jakub Hajny, Shutang Tan, Jiri Friml
Summary: The plant hormone auxin has the ability to promote formation of its own directional transport routes, which involves coordinated polarization of individual cells. This mechanism plays a crucial role in plant development.
CURRENT OPINION IN PLANT BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Vladimir Skalicky, Tereza Vojtkova, Ales Pencik, Jan Vrana, Katarzyna Juzon, Veronika Kolackova, Michaela Sedlarova, Martin F. Kubes, Ondrej Novak
Summary: This study tested various nuclear isolation protocols and combined with mass spectrometry analysis to obtain information on the auxinome from isolated nuclei of Arabidopsis and tobacco cell cultures, revealing dynamic changes in auxin homeostasis within the nucleus. The methodological procedure combining flow cytometry and mass spectrometry offers new horizons for the study of auxin homeostasis at the subcellular level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Yishi Shen, Hong-Mei Gu, Shucun Qin, Da-Wei Zhang
Summary: Surfeit 4 is a transmembrane protein involved in cargo transport between the ER and Golgi apparatus. It plays a crucial role in lipid metabolism and has been implicated in various physiological and pathophysiological processes. However, the molecular mechanisms underlying its selective sorting of diverse cargos for protein trafficking are still unclear.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2023)
Article
Cell Biology
Qiaoqiao Zhang, Hui Zheng, Shengye Yang, Tong Feng, Minwen Jie, Haiyang Chen, Hao Jiang
Summary: The Bub1-Bub3 complex, known for its role in chromosome alignment and separation during mitosis, is shown to regulate lipid degradation in the fat body of Drosophila. Levels of Bub1 or Bub3 affect tri-acylglycerol consumption and fly survival under starvation. This study reveals novel physiological roles of the Bub1-Bub3 complex in metabolic adaptation and lipid metabolism beyond mitotic functions.
Article
Cell Biology
Feng Geng, Yaogang Zhong, Huali Su, Etienne Lefai, Shino Magaki, Timothy F. Cloughesy, William H. Yong, Arnab Chakravarti, Deliang Guo
Summary: Cholesterol plays a crucial role in maintaining cell membrane structure. Glioblastoma, the most deadly brain tumor, maintains normal levels of membrane cholesterol by accumulating cholesteryl esters (CEs) in lipid droplets (LDs). The activation of the SREBP-1-autophagy-LD-CE hydrolysis pathway promotes LD lipophagy and release of cholesterol from lysosomes, ensuring membrane cholesterol homeostasis. Inhibition of this pathway leads to increased sensitivity to cholesterol deficiency and impairs the growth of GBM cells in vitro.
Article
Agriculture, Dairy & Animal Science
Jiangxue Cai, Qingmei Hu, Hai Lin, Jingpeng Zhao, Hongchao Jiao, Xiaojuan Wang
Summary: This study found that the expression of adiponectin varies in different tissues in broilers, and feed restriction can promote the utilization of fatty acids to maintain energy balance in the body.
Article
Biochemistry & Molecular Biology
Stacey L. Borrego, Johannes Fahrmann, Jue Hou, Da-Wei Lin, Bruce J. Tromberg, Oliver Fiehn, Peter Kaiser
Summary: The study reveals that Met stress in triple-negative breast cancer cells leads to a global decrease in lipid abundances, except for triglycerides, and an increase in lipid droplets. Additionally, specific gene expression changes were observed in response to Met stress in the cells.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Environmental Sciences
Ningbo Geng, Xiaoyao Song, Rong Cao, Yun Luo, A. Mila, Zhengang Cai, Kejie Yu, Yuan Gao, Yuwen Ni, Haijun Zhang, Jiping Chen
Summary: This study explored the metabolic toxicity of PM2.5 at environmentally relevant doses and investigated the seasonal variation and relationship with toxic components. Results showed that even at environmentally relevant doses, PM2.5 induced significant metabolic disorder, with high dose winter PM2.5 causing severe histopathological damage to the lungs in rats. Additionally, high levels of heavy metals and organic compounds in winter PM2.5 brought multiple overlaps on toxic pathways, leading to larger pulmonary toxicity and metabolic toxicity in rats compared to summer.
ENVIRONMENTAL POLLUTION
(2021)