Article
Multidisciplinary Sciences
Nihaad Paraouty, Catherine R. Rizzuto, Dan H. Sanes
Summary: This study examined the role of dopamine signals in social learning, revealing that providing a reward linked to the demonstrator's performance can significantly enhance learning speed for unrewarded observers, and this effect is abolished by using a D1/D5 dopamine receptor antagonist during exposure sessions, which also reduces the learning rate for unrewarded observers. On the other hand, administering a D1/D5 receptor agonist during exposure sessions without any reward present can accelerate the learning process significantly.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Helena J. Barr, Erin M. Wall, Sarah C. Woolley
Summary: Vocal communication signals can shape the incentive salience of communication signals through dopamine within auditory cortical circuits, not norepinephrine. Dopamine enhances preferences for less-preferred songs, and this plasticity can persist for at least 1 week.
Article
Neurosciences
Thomas Schueller, Sina Kohl, Till Dembek, Marc Tittgemeyer, Daniel Huys, Veerle Visser-Vandewalle, Ningfei Li, Laura Wehmeyer, Michael Barbe, Jens Kuhn, Juan Carlos Baldermann
Summary: Deep brain stimulation can effectively treat obsessive-compulsive disorder, but it may also increase impulsive behavior. This study investigated the effects of stimulation on impulsive decision making and found that it increased impulsivity. The effects were dependent on the location of the stimulation and the associated fiber bundles.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Review
Pharmacology & Pharmacy
Lucia Caffino, Francesca Mottarlini, Gianmaria Zita, Dawid Gawlinski, Kinga Gawlinska, Karolina Wydra, Edmund Przegalinski, Fabio Fumagalli
Summary: Drug addiction is a devastating disorder that poses a huge economic and social burden on modern society, with adolescents being particularly vulnerable. Research has shown that exposure to cocaine during adolescence confers a vulnerable endophenotype primarily by inducing changes in neuroplasticity.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Evelyn Ordones Sanchez, Debra A. Bangasser
Summary: Impulsivity is a common symptom in various psychiatric disorders, and early life stress has been found to affect impulsive behaviors and brain circuits associated with impulsivity, which is essential for developing treatments aimed at reducing impulsivity symptoms in psychiatric disorders.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Biology
Rawan AlSubaie, Ryan W. S. Wee, Anne Ritoux, Karyna Mishchanchuk, Jessica Passlack, Daniel Regester, Andrew F. MacAskill
Summary: Projections from the basal amygdala to the ventral hippocampus provide information about rewarding or threatening stimuli to support appropriate behavior. These projections consist of both excitatory and inhibitory inputs that control the activity of downstream neurons, ultimately affecting goal-directed behavior.
Article
Endocrinology & Metabolism
Georgia E. Kirkpatrick, Paige M. Dingess, Jake A. Aadland, Travis E. Brown
Summary: This study investigates whether forced exercise can attenuate the incubation of high-fat food craving. The results suggest that high-intensity exercise can prevent the establishment of incubation of craving for high-fat foods and may reduce cue-induced maladaptive food-seeking behaviors.
Article
Neurosciences
Franz R. Villaruel, Melissa Martins, Nadia Chaudhri
Summary: The neural circuit from the infralimbic cortex to the nucleus accumbens shell plays a crucial role in suppressing conditioned responding and renewal of CS responding. The IL-to-NAcS circuit is involved in both acquisition and expression of Pavlovian conditioning and is not exclusively dependent on extinction process.
JOURNAL OF NEUROSCIENCE
(2022)
Editorial Material
Biochemistry & Molecular Biology
Amrita R. Nair, Steve W. C. Chang
Summary: This study further explores the role of oxytocin in maintaining social relationships and its interaction with the endocannabinoid system.
Article
Behavioral Sciences
Lola Kaukas, Joshua L. Holmes, Freshta Rahimi, Lyndsey Collins-Praino, Frances Corrigan
Summary: Adolescents who experience mild traumatic brain injury (mTBI) are more likely to exhibit chronic symptoms in adulthood, with sex-specific effects on executive functions related to subtle changes in the developmental trajectory of the mesocortical limbic pathway in males only. In an experimental study with Sprague Dawley rats, mTBI during mid-adolescence led to different behavioral deficits in males and females, as well as an imbalance in dopaminergic innervation post-injury.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Laurie Hamel, Bilgehan Cavdaroglu, Dylan Yeates, David Nguyen, Sadia Riaz, Dylan Patterson, Nisma Khan, Nardin Kirolos, Katherine Roper, Quynh An Ha, Rutsuko Ito
Summary: The study aimed to investigate the role of the mPFC and NAc in cue-elicited adaptive responding, finding that the mPFC plays a crucial role in regulating nonreinforced cue responding.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Patrick T. Piantadosi, Lindsay R. Halladay, Anna K. Radke, Andrew Holmes
Summary: The risk of aversive consequences from reward-seeking behavior can significantly impact future actions, with individuals adapting differently to negative and positive punishment risks. Those with substance use disorders or behavioral addictions may struggle to reduce addictive behaviors despite aversive consequences. Dopamine signaling and interconnected ventral striatal, cortical, and amygdala regions play critical roles in punishment learning and risky reward seeking behavior.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Yang Li, Liang Qu, Nan Li, Xin Wang, Ping Wang, Shun-nan Ge, Xue-lian Wang
Summary: The study aimed to improve the success rate of rat jugular vein catheterization and the self-administration (SA) model through an optimized scheme. The results showed that the success rate in the optimized operation group was significantly higher than the traditional operation group. The optimized scheme made various improvements in materials and techniques, providing a more stable and efficient tool for basic research on drug addiction.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Kelle E. Nett, Alexa R. Zimbelman, Matthew S. McGregor, Vanessa Alizo Vera, Molly R. Harris, Ryan T. LaLumiere
Summary: Previous evidence suggests that the infralimbic cortex (IL) plays a role in inhibiting cocaine seeking behavior in rats. In this study, the researchers investigated whether IL activity and its outputs to the nucleus accumbens shell (NAshell) and amygdala are involved in encoding extinction contingencies following cocaine self-administration. They used optogenetic techniques to silence IL-NAshell or IL-amygdala activity after an unreinforced lever press during extinction training and found that inhibition of IL-NAshell or IL-amygdala activity impaired extinction retention.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Kevin M. Manz, Benjamin C. Coleman, Carrie A. Grueter, Brenda C. Shields, Michael R. Tadross, Brad A. Grueter
Summary: In the NAcSh, NE modulates glutamatergic synaptic transmission onto PV-INs by recruiting postsynaptically-localized alpha(2)-adrenergic receptors, decreasing PV-IN-dependent feedforward inhibition onto MSNs via optogenetic stimulation from cortical afferents.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Simon Leipold, Daniel A. Abrams, Shelby Karraker, Vinod Menon
Summary: This study reveals the brain regions associated with emotional prosody decoding in children and finds a link between decoding accuracy and social skills. Specifically, decoding of sadness is correlated with social communication abilities, highlighting the importance of attending to negative emotional vocal cues for social responsiveness and functioning.
Review
Neurosciences
Vinod Menon, Lena Palaniyappan, Kaustubh Supekar
Summary: Brain network models of cognitive control play a crucial role in understanding psychopathology and cognitive dysfunction in schizophrenia. This review examines the role of large-scale brain organization in schizophrenia, focusing on a triple-network model of cognitive control and its role in aberrant salience processing. The review summarizes evidence from structural, neurochemical, and functional brain imaging studies that highlight aberrancies in these networks and their dynamic interactions in schizophrenia. It also proposes an integrated model that incorporates striatal dysfunction and dysregulated dopamine modulation of salience network-centered processes in schizophrenia.
BIOLOGICAL PSYCHIATRY
(2023)
Editorial Material
Neurosciences
Lucina Q. Uddin
Summary: Network neuroscientists generally agree that human brain function is context-dependent and interactionally complex, and brain networks should be embraced as the functional units of interest. The way to define brain networks for further discovery is a contentious issue in the field. A group, including members from the Organization for Human Brain Mapping, is working towards cataloging best practices and providing reporting guidelines for the scientific community.
JOURNAL OF COGNITIVE NEUROSCIENCE
(2023)
Article
Neurosciences
Simon Leipold, Daniel A. Abrams, Shelby Karraker, Jennifer M. Phillips, Vinod Menon
Summary: This study found that children with autism have difficulties in recognizing emotions from voices, which are related to abnormal neural connectivity. Compared to typical children, children with autism showed aberrant functional connectivity between voice-sensitive auditory cortex and the temporoparietal junction (TPJ). Neural activity in the TPJ during processing of emotional prosody was associated with social communication impairments in children with autism, while activity and decoding of emotional prosody in auditory cortex did not predict social communication impairments and were similar between autism and control groups.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Neurosciences
Yoshifumi Mizuno, Weidong Cai, Kaustubh Supekar, Kai Makita, Shinichiro Takiguchi, Timothy J. Silk, Akemi Tomoda, Vinod Menon
Summary: This study found that methylphenidate can increase spontaneous neural activity in the nucleus accumbens and its associated brain circuitry. This increase in spontaneous activity is associated with improvements in sustained attention in children with ADHD. The findings of this study were replicated in two independent cohorts, revealing a novel neural mechanism underlying methylphenidate treatment in ADHD.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Psychology, Developmental
Mirko Uljarevic, Thomas W. Frazier, Booil Jo, Lawrence Scahill, Eric A. Youngstrom, Emily Spackman, Jennifer M. Phillips, Wesley Billingham, Antonio Hardan
Summary: The study aimed to validate the Dimensional Assessment of Restricted and Repetitive Behaviors (DARB), a new parent-report measure. Results showed that the DARB had good factor structure, reliability, and validity, and it can be useful in research and clinical contexts for autism spectrum disorder.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Clinical Neurology
Makoto Kawai, Casey Buck, Christina F. Chick, Lauren Anker, Lisa Talbot, Logan Schneider, Omer Linkovski, Isabelle Cotto, Kai Parker-Fong, Jennifer Phillips, Antonio Y. Hardan, Joachim Hallmayer, Ruth O'Hara
Summary: This study investigated the differences in sleep architecture between children and adolescents with autism spectrum disorder (ASD) and typically developing controls (TD). The results showed that participants with ASD had a higher slow-wave sleep (SWS) ratio and lower rapid eye movement (REM) sleep ratio compared to TD. In addition, increased SWS was associated with more severe core ASD symptoms.
Article
Neurosciences
Anup Das, Vinod Menon
Summary: Electrical stimulation of the medial temporal lobe (MTL) can reveal the causal circuit mechanisms underlying memory function. In this study, intracranial EEG recordings were used to investigate how MTL stimulation alters information flow between MTL and PFC, and between MTL and PPC, during a verbal episodic memory task. The results showed that MTL stimulation reduced memory recall, decreased PFC-MTL information flow, and had region-specific effects on directional signaling.
JOURNAL OF NEUROSCIENCE
(2023)
Editorial Material
Biochemical Research Methods
Jakub Kopal, Lucina Q. Uddin, Danilo Bzdok
Summary: Human neuroscience benefits from the increasing availability of population data resources, such as large-scale cohorts with extensive profiles on gene expression, brain scanning, and sociodemographic measures. The comprehensive phenotyping allows us to better examine the effects of population diversity in understanding the mechanisms underlying brain health.
Review
Neurosciences
Vinod Menon
Summary: The discovery of the default mode network has revolutionized our understanding of the human brain, playing a crucial role in self-reference, social cognition, memory, language, and consciousness.
Article
Neurosciences
Lucina Q. Uddin, Richard F. Betzel, Jessica R. Cohen, Jessica S. Damoiseaux, Felipe De Brigard, Simon B. Eickhoff, Alex Fornito, Caterina Gratton, Evan M. Gordon, Angela R. Laird, Linda Larson-Prior, A. Randal McIntosh, Lisa D. Nickerson, Luiz Pessoa, Ana Luisa Pinho, Russell A. Poldrack, Adeel Razi, Sepideh Sadaghiani, James M. Shine, Anastasia Yendiki, B. T. Thomas Yeo, R. Nathan Spreng
Summary: Progress in network neuroscience requires the development of a standardized taxonomy for fundamental constructs. The WHATNET committee conducted a survey on current practices in brain network nomenclature and identified challenges such as network scale, interindividual variability, dynamics, and multimodal information. They provide initial considerations and recommendations for standardized reporting.
NETWORK NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Istvan Molnar-Szakacs, Lucina Q. Uddin
Summary: Inspired by Eran Zaidel's pioneering work, this review examines the research on self-face recognition from a laterality perspective. Self-face recognition is an important indicator of self-awareness, and there is accumulating evidence, including behavioral, neurological, and neuroimaging data, suggesting a right-hemisphere dominance for self-face recognition. The review also discusses the influential neuroimaging literature on self-face recognition and future research directions.
Article
Neurosciences
Weidong Cai, Yoshifumi Mizuno, Akemi Tomoda, Vinod Menon
Summary: This study used a Bayesian dynamical system model to investigate the effects of methylphenidate on latent brain states and behavioral dynamics in children with ADHD. The results showed that methylphenidate improves behavioral variability and corrects abnormal brain state dynamics and connectivity in children with ADHD. The findings reveal the underlying brain state dynamical process and circuit mechanism of methylphenidate in treating childhood ADHD.
NEUROPSYCHOPHARMACOLOGY
(2023)