Article
Clinical Neurology
Anna K. Bonkhoff, Sungmin Hong, Martin Bretzner, Markus D. Schirmer, Robert W. Regenhardt, E. Murat Arsava, Kathleen Donahue, Marco Nardin, Adrian Dalca, Anne-Katrin Giese, Mark R. Etherton, Brandon L. Hancock, Steven J. T. Mocking, Elissa McIntosh, John Attia, Oscar Benavente, John W. Cole, Amanda Donatti, Christoph Griessenauer, Laura Heitsch, Lukas Holmegaard, Katarina Jood, Jordi Jimenez-Conde, Steven Kittner, Robin Lemmens, Christopher Levi, Caitrin W. McDonough, James Meschia, Chia-Ling Phuah, Arndt Rolfs, Stefan Ropele, Jonathan Rosand, Jaume Roquer, Tatjana Rundek, Ralph L. Sacco, Reinhold Schmidt, Pankaj Sharma, Agnieszka Slowik, Martin Soederholm, Alessandro Sousa, Tara M. Stanne, Daniel Strbian, Turgut Tatlisumak, Vincent Thijs, Achala Vagal, Johan Wasselius, Daniel Woo, Ramin Zand, Patrick McArdle, Bradford B. Worrall, Christina Jern, Arne G. Lindgren, Jane Maguire, Polina Golland, Danilo Bzdok, Ona Wu, Natalia S. Rost
Summary: This study examines the association between high white matter hyperintensity (WMH) burden and stroke severity and functional outcomes. The findings suggest that higher WMH burden may be associated with increased stroke severity and worse functional outcomes.
Article
Endocrinology & Metabolism
Tom Chambers, Richard Anney, Peter N. Taylor, Alexander Teumer, Robin P. Peeters, Marco Medici, Xavier Caseras, D. Aled Rees
Summary: The study found that a history of hypothyroidism was associated with significant reductions in cerebellar and pallidum gray matter volumes, partly mediated by increases in body mass index. It was also observed that polygenic scores for hypo- and hyperthyroidism had opposing influences on gray matter volumes, with no evidence of regional genetic pleiotropy with ADHD for either hypo- or hyperthyroidism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Neurosciences
Sarah E. Medland, Katrina L. Grasby, Neda Jahanshad, Jodie N. Painter, Lucia Colodro-Conde, Janita Bralten, Derrek P. Hibar, Penelope A. Lind, Fabrizio Pizzagalli, Sophia Thomopoulos, Jason L. Stein, Barbara Franke, Nicholas G. Martin, Paul M. Thompson
Summary: This article reviews the motivation for creating the ENIGMA Consortium and its genetic analyses. They have addressed the reproducibility crisis in neuroimaging genetics and identified common genomic loci associated with brain structure.
HUMAN BRAIN MAPPING
(2022)
Article
Multidisciplinary Sciences
Yuanyuan Li, Guangyi Jin, Boyang Sun, Zhehao Cui, Bishun Lu
Summary: Border tourism between China and North Korea has a significant impact on international economic and cultural cooperation. This study examines the temporal and spatial distribution characteristics and influencing factors of travel demands to North Korea using Baidu Index. It reveals that the travel demands showed an initial increase followed by a decrease from 2011 to 2018, with significant seasonal and spatial differences. Holidays, population, GDP, per capita disposable income, internet penetration, and education are the main factors influencing tourism demand to North Korea.
Article
Sport Sciences
Channa E. Marsh, Hannah J. Thomas, Louise H. Naylor, Lawrence G. Dembo, Katrina J. Scurrah, Daniel J. Green
Summary: Cardiac adaptation to exercise is modality-specific, and individuals who have a low response to one mode of exercise may have a high response to another. Genetic impact on adaptation to exercise is limited in this study.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Genetics & Heredity
Danielle N. Davis, Morgan D. Strong, Emily Chambers, Matthew D. Hart, Ahmed Bettaieb, Stephen L. Clarke, Brenda J. Smith, Barbara J. Stoecker, Edralin A. Lucas, Dingbo Lin, Winyoo Chowanadisai
Summary: The ZIP12 gene plays a crucial role in the nervous system and is associated with various diseases such as neural tube defects, psychiatric illnesses, and pulmonary hypertension. Drug compounds targeting ZIP12 function may be potential treatments for these conditions.
Article
Clinical Neurology
Hyo M. Lee, Seok-Jun Hong, Ravnoor Gill, Benoit Caldairou, Irene Wang, Jian-guo Zhang, Francesco Deleo, Dewi Schrader, Fabrice Bartolomei, Maxime Guye, Kyoo Ho Cho, Carmen Barba, Sanjay Sisodiya, Graeme Jackson, R. Edward Hogan, Lily Wong-Kisiel, Gregory D. Cascino, Andreas Schulze-Bonhage, Iscia Lopes-Cendes, Fernando Cendes, Renzo Guerrini, Boris Bernhardt, Neda Bernasconi, Andrea Bernasconi
Summary: This study explores the associations between Focal cortical dysplasia (FCD) and cytoarchitecture, gene expression, and axes of cortical organization. The findings suggest that the vulnerability of the frontal lobe to FCD may be due to early termination of prenatal neurogenesis and aberrant postnatal synaptogenesis.
Article
Clinical Neurology
Katiane R. Servelhere, Thiago Junqueira Ribeiro Rezende, Fabricio Diniz de Lima, Mariana Rabelo de Brito, Renan Flavio de Franca Nunes, Raphael F. Casseb, Jose Luiz Pedroso, Orlando Graziani P. Barsottini, Fernando Cendes, Marcondes C. Franca Jr
Summary: HSPs are characterized by brain damage, with genotype-specific patterns of abnormalities. Most HSP patients show brain and cerebellar involvement, with distinct damage patterns based on genetic subtypes.
MOVEMENT DISORDERS
(2021)
Article
Computer Science, Information Systems
Ran Wei, Sergio Rey, Elijah Knaap
Summary: This paper proposes a new method for neighborhood delineation using max-p regions to partition geographic space into homogeneous and geographically contiguous neighborhoods, and develops a new algorithm to address computational challenges. Experimental results demonstrate the effectiveness and efficiency of the method.
INTERNATIONAL JOURNAL OF GEOGRAPHICAL INFORMATION SCIENCE
(2021)
Article
Psychiatry
Peristera Paschou, Yin Jin, Kirsten Mueller-Vahl, Harald E. Moeller, Renata Rizzo, Pieter J. Hoekstra, Veit Roessner, Nanette Mol Debes, Yulia Worbe, Andreas Hartmann, Pablo Mir, Danielle Cath, Irene Neuner, Heike Eichele, Chencheng Zhang, Katarzyna Lewandowska, Alexander Munchau, Julius Verrel, Richard Musil, Tim J. Silk, Colleen A. Hanlon, Emily D. Bihun, Valerie Brandt, Andrea Dietrich, Natalie Forde, Christos Ganos, Deanna J. Greene, Chunguang Chu, Michel J. Grothe, Tamara Hershey, Piotr Janik, Jonathan M. Koller, Juan Francisco Martin-Rodriguez, Karsten Mueller, Stefano Palmucci, Adriana Prato, Shukti Ramkiran, Federica Saia, Natalia Szejko, Renzo Torrecuso, Zeynep Tumer, Anne Uhlmann, Tanja Veselinovic, Tomasz Wolanczyk, Jade-Jocelyne Zouki, Pritesh Jain, Apostolia Topaloudi, Mary Kaka, Zhiyu Yang, Petros Drineas, Sophia Thomopoulos, Tonya White, Dick J. Veltman, Lianne Schmaal, Dan J. Stein, Jan Buitelaar, Barbara Franke, Odile van den Heuvel, Neda Jahanshad, Paul M. Thompson, Kevin J. Black
Summary: TS is characterized by multiple motor and vocal tics and high comorbidity rates with other neuropsychiatric disorders. The ENIGMA-TS working group aims to understand brain structure and function in TS and related disorders through collaborative efforts and transdiagnostic approaches.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Psychology, Clinical
Nuno Vouga Ribeiro, Vania Tavares, Elvira Bramon, Timothea Toulopoulou, Isabel Valli, Sukhi Shergill, Robin Murray, Diana Prata
Summary: This study aimed to replicate the effects of certain SNPs on brain volume in individuals with psychotic illnesses. The study found associations between several SNPs and brain structure, with some results aligning with previous research findings.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Geography
Xin Feng, Sergio Rey, Ran Wei
Summary: This article discusses how to integrate a compactness measure into the max-p regionalization process by constructing a multiobjective optimization model that maximizes the number of regions while optimizing the compactness of identified regions. An efficient heuristic algorithm is developed to address the computational intensity of the max-p-compact-regions problem so that it can be applied to large-scale practical regionalization problems. The new algorithm will be implemented in the open-source Python Spatial Analysis Library, showcasing its effectiveness and efficiency through hypothetical and practical applications of the max-p-compact-regions problem.
TRANSACTIONS IN GIS
(2022)
Article
Clinical Neurology
Allison Jack, Catherine A. W. Sullivan, Elizabeth Aylward, Susan Y. Bookheimer, Mirella Dapretto, Nadine Gaab, John D. Van Horn, Jeffrey Eilbott, Zachary Jacokes, Carinna M. Torgerson, Raphael A. Bernier, Daniel H. Geschwind, James C. McPartland, Charles A. Nelson, Sara J. Webb, Kevin A. Pelphrey, Abha R. Gupta
Summary: The study found significant differences in the brain response to human motion between females with ASD and typically developing females, particularly in sensorimotor, striatal, and frontal regions. Females with ASD also showed larger rare copy number variants containing early-life expressed genes, especially in striatal genes. These findings suggest that impacts on the striatum may contribute to pathways of risk in female ASD.
Article
Neurosciences
J. M. Stephen, I Solis, J. Janowich, M. Stern, M. R. Frenzel, J. A. Eastman, M. S. Mills, C. M. Embury, N. M. Coolidge, E. Heinrichs-Graham, A. Mayer, J. Liu, Y. P. Wang, T. W. Wilson, V. D. Calhoun
Summary: The study highlights the importance of multimodal data collection and analysis to enhance our understanding of brain development, shedding light on the roles of genetic and epigenetic mechanisms underlying brain structure and function.
Review
Radiology, Nuclear Medicine & Medical Imaging
Santo Maimone, Laura K. Harper, Sarah K. Mantia, Pooja P. Advani, Alexander P. Hochwald, Zhuo Li, Stephanie L. Hines, Bhavika Patel
Summary: The purpose of this study was to examine the MRI phenotypes of breast cancers in patients with different pathogenic variants and assess imaging trends and associations. A retrospective review of 410 patients with breast cancer and a predisposing pathogenic variant who underwent breast MRI at time of cancer diagnosis was conducted. The study found that BRCA1 and BRCA2 variants were the most common, followed by CHEK2, ATM, and PALB2, with significant associations in race/ethnicity, age at cancer diagnosis, tumor characteristics, internal enhancement pattern, kinetics, and presence of necrosis. The conclusions suggest that genetic and molecular profiles of breast cancers demonstrate reproducible MRI phenotypes.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Clinical Neurology
Daniel E. Gustavson, Chandra A. Reynolds, Timothy J. Hohman, Angela L. Jefferson, Jeremy A. Elman, Matthew S. Panizzon, Michael C. Neale, Mark W. Logue, Michael J. Lyons, Carol E. Franz, William S. Kremen
Summary: The study demonstrated that AD-PRSs were associated with declines in episodic memory and executive function in cognitively normal middle-aged men, with these declines potentially driven by a combination of APOE and non-APOE genetic influences.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2023)
Article
Psychology, Clinical
Wisteria Deng, Jean Addington, Carrie E. Bearden, Kristin S. Cadenhead, Barbara A. Cornblatt, Daniel H. Mathalon, Diana O. Perkins, Larry J. Seidman, Ming T. Tsuang, Scott W. Woods, Elaine F. Walker, Tyrone D. Cannon
Summary: This study found that there are different covariant trajectories of social anxiety and positive symptoms over time in individuals at clinical high-risk for psychosis. One subgroup showed sustained social anxiety despite moderate recovery in positive symptoms, while the other two subgroups showed recovery in both social anxiety and positive symptoms. The subgroup with sustained social anxiety had poorer long-term functional outcomes and higher levels of genetic and environmental risk factors for psychosis.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Alexis C. Garduno, Gail A. Laughlin, Jaclyn Bergstrom, Xin M. Tu, Kevin M. Cummins, Carol E. Franz, Jeremy A. Elman, Michael J. Lyons, Chandra A. Reynolds, Michael C. Neale, Nathan A. Gillespie, Hong Xian, Ruth E. McKenzie, Rosemary Toomey, William S. Kremen, Matthew S. Panizzon, Linda K. McEvoy
Summary: This study found minimal associations between alcohol consumption and cognitive aging among middle-aged men. Performance declined over time in all domains. Former drinkers had worse verbal fluency performance, and at-risk drinkers showed faster working memory decline. Light and moderate drinking did not have a protective association with the rate of cognitive decline. However, light drinkers may have better memory performance at older ages.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2023)
Article
Psychology, Developmental
Elsje van Bergen, Sara A. Hart, Antti Latvala, Eero Vuoksimaa, Asko Tolvanen, Minna Torppa
Summary: Children who enjoy reading and writing tend to have better literacy skills. Genetic factors play a significant role in both skills and enjoyment, while shared-environmental influences also have an impact. The study suggests that literacy skills influence enjoyment, but not the other way around. Nurturing children's literacy skills is crucial for their development.
DEVELOPMENTAL SCIENCE
(2023)
Article
Psychiatry
Lauren N. N. Tronick, Heline Mirzakhanian, Jean Addington, Carrie E. E. Bearden, Tyrone D. D. Cannon, Barbara A. A. Cornblatt, Matcheri Keshavan, Daniel H. H. Mathalon, Thomas H. H. McGlashan, Diana O. O. Perkins, William Stone, Ming T. T. Tsuang, Elaine F. F. Walker, Scott W. W. Woods, Kristin S. S. Cadenhead
Summary: This study aims to explore the risk of violence in individuals at clinical high risk for psychosis (CHR) and its relationship with psychosis risk symptoms and global functioning. It shows that CHR individuals are at higher risk of violence compared to healthy individuals and that this risk is associated with greater severity of symptoms, poor functioning, and risk for conversion to psychosis.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Article
Psychiatry
Mariapaola Barbato, Lu Liu, Carrie E. Bearden, Kristin S. Cadenhead, Barbara A. Cornblatt, Matcheri Keshavan, Daniel H. Mathalon, Thomas H. McGlashan, Diana O. Perkins, Larry J. Seidman, William Stone, Ming T. Tsuang, Elaine F. Walker, Scott W. Woods, Tyrone D. Cannon, Jean Addington
Summary: This study aimed to assess the impact of migrant status on clinical symptoms and functional outcome in individuals at clinical high risk (CHR) for psychosis. The results showed no significant differences in symptoms or functioning between different groups at any time point. However, significant improvements in symptoms and functioning were observed within each group over time. Transition rates did not differ across groups.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Letter
Psychiatry
Yash B. Joshi, Juan L. Molina, David L. Braff, Michael F. Green, Ruben C. Gur, Raquel E. Gur, Keith H. Nuechterlein, William S. Stone, Tiffany A. Greenwood, Laura C. Lazzeroni, Allen D. Radant, Jeremy M. Silverman, Joyce Sprock, Catherine A. Sugar, Debby W. Tsuang, Ming T. Tsuang, Bruce I. Turetsky, Neal R. Swerdlow, Gregory A. Light
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Neurosciences
Anni Varjonen, Claudia Schwarz, Eero Vuoksimaa
Summary: Twin samples can provide a valuable approach to study brain-cognition associations while controlling for genetic and environmental factors. This review focuses on studies that used a discordant co-twin design to investigate the associations between brain imaging markers of Alzheimer's disease and cognition. The results suggest that hippocampal volume, cortical thickness, glucose metabolism rate, neuroinflammation, and amyloid and tau accumulations may play a role in cognitive performance and Alzheimer's disease.
Article
Psychiatry
Matthew A. Hagler, Maria Ferrara, Laura A. Yoviene Sykes, Fangyong Li, Jean Addington, Carrie E. Bearden, Kristin S. Cadenhead, Tyrone D. Cannon, Barbara A. Cornblatt, Diana O. Perkins, Daniel H. Mathalon, Larry J. Seidman, Ming T. Tsuang, Elaine F. Walker, Albert R. Powers III, Adrienne R. Allen, Vinod H. Srihari, Scott W. Woods
Summary: Over the past two decades, research and clinical resources on clinical high risk (CHR) for psychosis have expanded, aiming to understand risk and protective factors and inform early intervention efforts. However, potential sampling bias among CHR research studies and inequitable access to early detection and intervention have been raised. This study compared participants in a CHR longitudinal monitoring study (CHR-CV) to those seeking treatment at a first-episode psychosis service (FES), finding demographic and clinical differences between the groups.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychiatry
Timothy I. Michaels, Ricardo E. Carrion, Jean Addington, Carrie E. Bearden, Kristin S. Cadenhead, Tyrone D. Cannon, Matcheri Keshavan, Daniel H. Mathalon, Thomas H. McGlashan, Diana O. Perkins, Larry J. Seidman, William S. Stone, Ming T. Tsuang, Elaine F. Walker, Scott W. Woods, Barbara A. Cornblatt
Summary: This study explored the association between perceived discrimination and positive symptoms in individuals at clinical high-risk for psychosis. The findings suggest that CHR individuals are more likely to experience lifetime and past year discrimination related to their race and ethnicity, and this discrimination is significantly associated with baseline positive symptoms.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychology, Clinical
Katrina Aberizk, Esra Sefik, Jean Addington, Alan Anticevic, Carrie E. E. Bearden, Kristin S. S. Cadenhead, Tyrone D. D. Cannon, Barbara A. A. Cornblatt, Matcheri Keshavan, Daniel H. H. Mathalon, Diana O. O. Perkins, William S. S. Stone, Ming T. T. Tsuang, Scott W. W. Woods, Elaine F. F. Walker
Summary: This study found that reduced hippocampal volume is a brain morphological feature of psychiatric conditions. It also observed associations between hippocampal volume and hippocampal functional connectivity with the inferior parietal lobe and thalamus. The results suggest that the functional connectivity of the hippocampus with the temporoparietal junction within the default mode network is sensitive to hippocampal volume.
CLINICAL PSYCHOLOGICAL SCIENCE
(2023)
Article
Neurosciences
Donovan J. Roediger, Claire Griffin, Frances Marin, Hannah Verdoorn, Mark Fiecas, Bryon A. Mueller, Kelvin O. Lim, Jazmin Camchong
Summary: This study examined whether microstructural measures in white matter pathways associated with relapse in alcohol use disorder (AUD). The findings showed that anisotropy measures in these pathways were generally lower in those who relapsed during the follow-up period and positively associated with the duration of sustained abstinence. However, only the right fornix showed significant results in this sample. This highlights the potential utility of the three-factor model of addiction and the role of white matter alterations in AUD treatment outcomes.
Article
Neurosciences
Benson S. Ku, Meghan Collins, Deidre M. Anglin, Anthony M. Diomino, Jean Addington, Carrie E. Bearden, Kristin S. Cadenhead, Tyrone D. Cannon, Barbara A. Cornblatt, Benjamin G. Druss, Matcheri Keshavan, Daniel H. Mathalon, Diana O. Perkins, William S. Stone, Ming T. Tsuang, Scott W. Woods, Elaine F. Walker
Summary: The study found an inverse relationship between ethnoracial minority density and risk of psychotic spectrum disorders. It also revealed associations between area-level ethnoracial minority density during childhood, cortical thickness, and social engagement. Lower levels of ethnoracial minority density during childhood were associated with reduced cortical thickness in the right fusiform gyrus and right insula, especially among youth with lower social engagement.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Benson S. Ku, Jean Addington, Carrie E. Bearden, Kristin S. Cadenhead, Tyrone D. Cannon, Michael T. Compton, Barbara A. Cornblatt, Benjamin G. Druss, Sinan Guloksuz, Daniel H. Mathalon, Diana O. Perkins, Ming T. Tsuang, Elaine F. Walker, Scott W. Woods, Ricardo E. Carrion
Summary: Although studies have shown that social fragmentation is a risk factor for schizophrenia and other psychotic disorders, its impact on social functioning is still unknown. This study found that social fragmentation during childhood predicts maladaptation to school and poorer social functioning during adulthood.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Clinical Neurology
Toni T. Saari, Eero Vuoksimaa
Summary: This study examined the association between handedness and neuropsychological performance and neuropsychiatric symptoms in individuals with common neurodegenerative diseases. The findings suggest that handedness does not impact cognitive performance or symptoms of neurodegenerative diseases.
BRAIN COMMUNICATIONS
(2023)