How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function

Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β-Lactams

(2012) Maya A. Farha et al.   ACS Chemical Biology

Potent Small-Molecule Suppression of Oxacillin Resistance in Methicillin-ResistantStaphylococcus aureus

(2012) Tyler L. Harris et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Allostery and the Monod-Wyman-Changeux Model After 50 Years

(2012) Jean-Pierre Changeux   Annual Review of Biophysics

An Antibiotic That Inhibits a Late Step in Wall Teichoic Acid Biosynthesis Induces the Cell Wall Stress Stimulon in Staphylococcus aureus

(2012) Jennifer Campbell et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural Studies on 4,5-Disubstituted 2-Aminoimidazole-Based Biofilm Modulators that Suppress Bacterial Resistance to β-Lactams

(2012) Zhaoming Su et al.   ChemMedChem

Characterization of methicillin-resistant Staphylococcus aureus displaying increased MICs of ceftaroline

(2012) R. E. Mendes et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Structural Insights into the Anti-methicillin-resistantStaphylococcus aureus(MRSA) Activity of Ceftobiprole

(2012) Andrew L. Lovering et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Properties of a Novel PBP2A Protein Homolog fromStaphylococcus aureusStrain LGA251 and Its Contribution to the β-Lactam-resistant Phenotype

(2012) Choonkeun Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structures of Penicillin-Binding Protein 3 (PBP3) from Methicillin-Resistant Staphylococcus aureus in the Apo and Cefotaxime‐Bound Forms

(2012) Hisashi Yoshida et al.   JOURNAL OF MOLECULAR BIOLOGY

Mutations in Streptococcus pneumoniae Penicillin-Binding Protein 2x: Importance of the C-Terminal Penicillin-Binding Protein and Serine/Threonine Kinase-Associated Domains for Beta-Lactam Binding

(2012) Patrick Maurer et al.   Microbial Drug Resistance

Distinct Single-Cell Morphological Dynamics under Beta-Lactam Antibiotics

(2012) Zhizhong Yao et al.   MOLECULAR CELL

Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids

(2012) S. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restoring Methicillin-Resistant Staphylococcus aureus Susceptibility to  -Lactam Antibiotics

(2012) C. M. Tan et al.   Science Translational Medicine

Structure-Guided Design of Cell Wall Biosynthesis Inhibitors That Overcome β-Lactam Resistance inStaphylococcus aureus(MRSA)

(2011) Carlos Contreras-Martel et al.   ACS Chemical Biology

Antagonism of Chemical Genetic Interaction Networks Resensitize MRSA to β-Lactam Antibiotics

(2011) Sang Ho Lee et al.   CHEMISTRY & BIOLOGY

Ceftaroline: A Novel Cephalosporin with Activity against Methicillin-resistant Staphylococcus aureus

(2011) L. D. Saravolatz et al.   CLINICAL INFECTIOUS DISEASES

A Computational Evaluation of the Mechanism of Penicillin-Binding Protein-Catalyzed Cross-Linking of the Bacterial Cell Wall

(2011) Qicun Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Methicillin-Resistance in Staphylococcus aureus Is Not Affected by the Overexpression in Trans of the mecA Gene Repressor: A Surprising Observation

(2011) Duarte C. Oliveira et al.   PLoS One

Unprecedented inhibition of resistant penicillin binding proteins by bis-2-oxoazetidinyl macrocycles

(2011) Aline Sliwa et al.   MedChemComm

Synthetic Lethal Compound Combinations Reveal a Fundamental Connection between Wall Teichoic Acid and Peptidoglycan Biosyntheses inStaphylococcus aureus

(2010) Jennifer Campbell et al.   ACS Chemical Biology

Recognition of peptidoglycan and β-lactam antibiotics by the extracellular domain of the Ser/Thr protein kinase StkP fromStreptococcus pneumoniae

(2010) Beatriz Maestro et al.   FEBS LETTERS

Unusual Conformation of the SxN Motif in the Crystal Structure of Penicillin-Binding Protein A from Mycobacterium tuberculosis

(2010) Alena Fedarovich et al.   JOURNAL OF MOLECULAR BIOLOGY

The Extended Conformation of the 2.9-Å Crystal Structure of the Three-PASTA Domain of a Ser/Thr Kinase from the Human Pathogen Staphylococcus aureus

(2010) Patricia Paracuellos et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Basis and Phenotype of Methicillin Resistance in Staphylococcus aureus and Insights into New  -Lactams That Meet the Challenge

(2009) L. I. Llarrull et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Chemical Genetic Identification of Peptidoglycan Inhibitors Potentiating Carbapenem Activity against Methicillin-Resistant Staphylococcus aureus

(2009) Joann Huber et al.   CHEMISTRY & BIOLOGY

In Vitro Selection and Characterization of Ceftobiprole-Resistant Methicillin-Resistant Staphylococcus aureus

(2008) R. Banerjee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Co-opting the Cell Wall in Fighting Methicillin-ResistantStaphylococcus aureus: Potent Inhibition of PBP 2a by Two Anti-MRSA β-Lactam Antibiotics

(2008) Adriel Villegas-Estrada et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Allosteric regulation and catalysis emerge via a common route

(2008) Nina M Goodey et al.   Nature Chemical Biology