Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assay

Activity-Based Protein Profiling of the Escherichia coli GlpG Rhomboid Protein Delineates the Catalytic Core

(2012) Allison R. Sherratt et al.   BIOCHEMISTRY

Conformational Change in Rhomboid Protease GlpG Induced by Inhibitor Binding to Its S′ Subsites

(2012) Yi Xue et al.   BIOCHEMISTRY

Activity-Based Probes for the Study of Proteases: Recent Advances and Developments

(2012) Sevnur Serim et al.   ChemMedChem

Protease signalling: the cutting edge

(2012) Boris Turk et al.   EMBO JOURNAL

New approaches for dissecting protease functions to improve probe development and drug discovery

(2012) Edgar Deu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Synthesis and biological evaluation of novel irreversible serine protease inhibitors using amino acid based sulfonyl fluorides as an electrophilic trap

(2011) Arwin J. Brouwer et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Alkyne derivatives of isocoumarins as clickable activity-based probes for serine proteases

(2011) Ute Haedke et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Catalytic Mechanism of Rhomboid Protease GlpG Probed by 3,4-Dichloroisocoumarin and Diisopropyl Fluorophosphonate

(2011) Yi Xue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into Substrate Gating in H. influenzae Rhomboid

(2011) Cory L. Brooks et al.   JOURNAL OF MOLECULAR BIOLOGY

Monocyclic β-Lactams Are Selective, Mechanism-Based Inhibitors of Rhomboid Intramembrane Proteases

(2010) Olivier A. Pierrat et al.   ACS Chemical Biology

Taking the plunge: integrating structural, enzymatic and computational insights into a unified model for membrane-immersed rhomboid proteolysis

(2010) Sinisa Urban   BIOCHEMICAL JOURNAL

Current Strategies for Probing Substrate Specificity of Proteases

(2010) M. Poreba et al.   CURRENT MEDICINAL CHEMISTRY

The structural basis for catalysis and substrate specificity of a rhomboid protease

(2010) Kutti R Vinothkumar et al.   EMBO JOURNAL

Insights into the effect of detergents on the full-length rhomboid protease from Pseudomonas aeruginosa and its cytosolic domain

(2009) Allison R. Sherratt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Intramembrane Proteolysis

(2009) Michael S. Wolfe   CHEMICAL REVIEWS

The Processing of Human Rhomboid Intramembrane Serine Protease RHBDL2 Is Required for Its Proteolytic Activity

(2009) Xiaojun Lei et al.   JOURNAL OF MOLECULAR BIOLOGY

Sequence-Specific Intramembrane Proteolysis: Identification of a Recognition Motif in Rhomboid Substrates

(2009) Kvido Strisovsky et al.   MOLECULAR CELL

How intramembrane proteases bury hydrolytic reactions in the membrane

(2009) Elinor Erez et al.   NATURE

Synthesis of β-aminoethanesulfonyl fluorides or 2-substituted taurine sulfonyl fluorides as potential protease inhibitors

(2009) Arwin J. Brouwer et al.   TETRAHEDRON LETTERS

Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry

(2008) Benjamin F. Cravatt et al.   Annual Review of Biochemistry