期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 110, 期 19, 页码 7886-7891出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1305219110
关键词
inhibitory interneuron; bistability; neural noise; fluctuations; cortex
资金
- Deutsche Forschungsgemeinschaft
- Studienstiftung des Deutschen Volkes
- Howard Hughes Medical Institute
- Office of Naval Research [N00014-97-1-0422]
Cortical spike trains are highly irregular both during ongoing, spontaneous activity and when driven at high firing rates. There is uncertainty about the source of this irregularity, ranging from intrinsic noise sources in neurons to collective effects in large-scale cortical networks. Cortical interneurons display highly irregular spike times (coefficient of variation of the interspike intervals > 1) in response to dc-current injection in vitro. This is in marked contrast to cortical pyramidal cells, which spike highly irregularly in vivo, but regularly in vitro. We show with in vitro recordings and computational models that this is due to the fast activation kinetics of interneuronal K+ currents. This explanation holds over a wide parameter range and with Gaussian white, power-law, and Ornstein-Uhlenbeck noise. The intrinsically irregular spiking of interneurons could contribute to the irregularity of the cortical network.
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