Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily

Microsomal prostaglandin E synthase-1 exhibits one-third-of-the-sites reactivity

(2011) Shan He et al.   BIOCHEMICAL JOURNAL

Location of Inhibitor Binding Sites in the Human Inducible Prostaglandin E Synthase, MPGES1

(2011) Edward B. Prage et al.   BIOCHEMISTRY

Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1

(2010) Sven-Christian Pawelzik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arginine 104 Is a Key Catalytic Residue in Leukotriene C4Synthase

(2010) Agnes Rinaldo-Matthis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Common structural features of mapeg-a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism

(2010) Per-Johan Jakobsson et al.   PROTEIN SCIENCE

Microsomal glutathione transferase 1 exhibits one-third-of-the-sites-reactivity towards glutathione

(2009) Johan Ålander et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

On the mechanism of microsomal prostaglandin E synthase type-2—A theoretical study of endoperoxide reaction with MeS−

(2009) Yi Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Comparison of microsomal prostaglandin E synthase-1 deletion and COX-2 inhibition in acute cardiac ischemia in mice

(2009) Dongmei Wu et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Catalysis within the lipid bilayer—structure and mechanism of the MAPEG family of integral membrane proteins

(2008) D MARTINEZMOLINA et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Mutation of a Critical Arginine in Microsomal Prostaglandin E Synthase-1 Shifts the Isomerase Activity to a Reductase Activity That Converts Prostaglandin H2into Prostaglandin F2α

(2008) Tove Hammarberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MF63 [2-(6-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation

(2008) D. Xu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Structural basis for induced formation of the inflammatory mediator prostaglandin E2

(2008) C. Jegerschold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA