MuSK IgG4 autoantibodies cause myasthenia gravis by inhibiting binding between MuSK and Lrp4

The Role of MuSK in Synapse Formation and Neuromuscular Disease

(2013) S. J. Burden et al.   Cold Spring Harbor Perspectives in Biology

Morvan syndrome: Clinical and serological observations in 29 cases

(2012) Sarosh R. Irani et al.   ANNALS OF NEUROLOGY

Muscle-specific kinase myasthenia gravis IgG4 autoantibodies cause severe neuromuscular junction dysfunction in mice

(2012) Rinse Klooster et al.   BRAIN

Passive and active immunization models of MuSK-Ab positive myasthenia: Electrophysiological evidence for pre and postsynaptic defects

(2012) Stuart Viegas et al.   EXPERIMENTAL NEUROLOGY

Neuregulin-1 potentiates agrin-induced acetylcholine receptor clustering through muscle-specific kinase phosphorylation

(2012) S. T. Ngo et al.   JOURNAL OF CELL SCIENCE

Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface

(2012) Giovanni Di Zenzo et al.   JOURNAL OF CLINICAL INVESTIGATION

Divalent and monovalent autoantibodies cause dysfunction of MuSK by distinct mechanisms in a rabbit model of myasthenia gravis

(2012) Shuuichi Mori et al.   JOURNAL OF NEUROIMMUNOLOGY

Antibodies against Wnt receptor of muscle-specific tyrosine kinase in myasthenia gravis

(2012) Masaharu Takamori et al.   JOURNAL OF NEUROIMMUNOLOGY

Biglycan Is an Extracellular MuSK Binding Protein Important for Synapse Stability

(2012) A. R. Amenta et al.   JOURNAL OF NEUROSCIENCE

Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses

(2012) Norihiro Yumoto et al.   NATURE

Antibodies against Muscle-Specific Kinase Impair Both Presynaptic and Postsynaptic Functions in a Murine Model of Myasthenia Gravis

(2011) Shuuichi Mori et al.   AMERICAN JOURNAL OF PATHOLOGY

Autoantibodies to Lipoprotein-Related Protein 4 in Patients With Double-Seronegative Myasthenia Gravis

(2011) John S. Tzartos   ARCHIVES OF NEUROLOGY

Agrin Binds to the N-terminal Region of Lrp4 Protein and Stimulates Association between Lrp4 and the First Immunoglobulin-like Domain in Muscle-specific Kinase (MuSK)

(2011) Wei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-LRP4 autoantibodies in AChR- and MuSK-antibody-negative myasthenia gravis

(2011) Alexandra Pevzner et al.   JOURNAL OF NEUROLOGY

Anti-MuSK autoantibodies block binding of collagen Q to MuSK

(2011) Y. Kawakami et al.   NEUROLOGY

Autoantibodies to low-density lipoprotein receptor-related protein 4 in myasthenia gravis

(2010) Osamu Higuchi et al.   ANNALS OF NEUROLOGY

Epitope specificity and significance in systemic autoimmune diseases

(2010) Michael Mahler et al.   Annals of the New York Academy of Sciences

Rituximab therapy leads to rapid decline of serum IgG4 levels and prompt clinical improvement in IgG4-related systemic disease

(2010) Arezou Khosroshahi et al.   ARTHRITIS AND RHEUMATISM

Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L

(2010) P. T. Hallock et al.   GENES & DEVELOPMENT

Patient autoantibodies deplete postsynaptic muscle-specific kinase leading to disassembly of the ACh receptor scaffold and myasthenia gravis in mice

(2010) R. N. Cole et al.   JOURNAL OF PHYSIOLOGY-LONDON

Main Immunogenic Region Structure Promotes Binding of Conformation-Dependent Myasthenia Gravis Autoantibodies, Nicotinic Acetylcholine Receptor Conformation Maturation, and Agonist Sensitivity

(2009) J. Luo et al.   JOURNAL OF NEUROSCIENCE

M-Type Phospholipase A2Receptor as Target Antigen in Idiopathic Membranous Nephropathy

(2009) Laurence H. Beck et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lrp4 Is a Receptor for Agrin and Forms a Complex with MuSK

(2008) Natalie Kim et al.   CELL

Clinical fluctuations in MuSK myasthenia gravis are related to antigen-specific IgG4 instead of IgG1

(2008) E.H. Niks et al.   JOURNAL OF NEUROIMMUNOLOGY

LRP4 Serves as a Coreceptor of Agrin

(2008) Bin Zhang et al.   NEURON