Article
Multidisciplinary Sciences
Elissa L. Newport, Anna Seydell-Greenwald, Barbara Landau, Peter E. Turkeltaub, Catherine E. Chambers, Kelly C. Martin, Rebecca Rennert, Margot Giannetti, Alexander W. Dromerick, Rebecca N. Ichord, Jessica L. Carpenter, Madison M. Berl, William D. Gaillard
Summary: The mature human brain is lateralized for language, with the left hemisphere primarily responsible for sentence processing and the right hemisphere primarily responsible for processing suprasegmental aspects of language. It has been hypothesized that there is plasticity for language in early life, allowing young children to acquire language in other cortical regions when LH areas are damaged. This reorganization is highly constrained, with sentence processing almost always occurring in the right hemisphere frontotemporal regions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Editorial Material
Biochemistry & Molecular Biology
Hubert R. Dinse
Summary: Compared to adults, children's learning process is different and more efficient. A recent study reveals that children experience a rapid increase in inhibition during learning, leading to better retention of learned information by reducing retrograde interference.
Article
Oncology
Christian D. Diehl, Enrike Rosenkranz, Maximilian Schwendner, Martin Misslbeck, Nico Sollmann, Sebastian Ille, Bernhard Meyer, Stephanie E. Combs, Sandro M. Krieg
Summary: Management of brain metastases adjacent to motor structures is challenging. Navigated transcranial magnetic stimulation (nTMS) motor mapping combined with diffusion tensor imaging (DTI)-based fiber tracking (DTI-FTmot.TMS) is used for safe resection and to preserve motor function. This study investigated the applicability of DTI-FTmot.TMS in adjuvant radiotherapy planning, demonstrating a potential significant reduction in dose to motor structures.
Review
Ecology
Mylene M. Mariette, David F. Clayton, Katherine L. Buchanan
Summary: Conditions experienced prenatally have lifelong effects on individual phenotypes and fitness, ultimately influencing population dynamics. Prenatal acoustic signals can program individual phenotypes for predicted postnatal environmental conditions, improving fitness. Embryos across taxonomic groups have shown immediate adaptive responses to external sounds and vibrations, indicating direct developmental effects of sound and noise.
TRENDS IN ECOLOGY & EVOLUTION
(2021)
Article
Multidisciplinary Sciences
Airi Watanabe, Connie Guo, Per Jesper Sjostrom
Summary: We studied the maturation process of astrocytes in the layer 5 mouse visual cortex from postnatal days 3-50. We observed an increase in resting membrane potential, a decrease in input resistance, and a transition towards more passive membrane responses as the astrocytes matured. Gap-junction coupling increased starting around postnatal day 7. Morphological reconstructions showed increased branch density but shorter branches after postnatal day 20, indicating branch pruning during tiling establishment. Additionally, spontaneous Ca2+ transients became decorrelated, more frequent, and briefer with age, suggesting a shift from cell-wide, synchronous waves to local transients as astrocytes matured. Some astrocyte properties were stably mature by postnatal day 15, coinciding with eye opening, while morphology continued to develop. Our findings provide a descriptive foundation for astrocyte maturation and its impact on visual cortex critical period plasticity.
Article
Neurosciences
Fang-Cheng Yeh, Andrei Irimia, Dhiego Chaves de Almeida Bastos, Alexandra J. Golby
Summary: This review discusses the challenges of anatomical accuracy in fiber tracking, explores the impact of different white matter pathways on tracking methods, and summarizes the pros and cons of commonly-used techniques. Additionally, it introduces the progress in clinical applications of tractography in patients with brain tumors and traumatic brain injury, highlighting current limitations and future directions for development.
Article
Multidisciplinary Sciences
Honggang Wang, Junlong Guo, Shuo Pei, Jiajia Wang, Yufeng Yao
Summary: This study proposes a generic modeling and motion extraction method, P-BTBS, for human upper limb. It follows the physiology of upper limbs, allows high accuracy of motion angles, and describes upper-limb motions with high accuracy. Experiments validated the excellent performance and robustness of P-BTBS in extracting motion information and describing upper-limb motions.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Isabella Loughland, Alexander Little, Frank Seebacher
Summary: The study reveals that DNMT3a plays a key role in regulating developmental thermal plasticity, and the phenotypic effects of different DNMT3a isoforms are additive. However, DNMT3a interacts with other mechanisms, such as histone (de)acetylation, induced during short-term acclimation to buffer phenotypes from environmental change. These interactions make phenotypic compensation for climate change more efficient.
Article
Multidisciplinary Sciences
Giorgia Dellaferrera, Stanislaw Wozniak, Giacomo Indiveri, Angeliki Pantazi, Evangelos Eleftheriou
Summary: The article proposes a brain-inspired optimizer based on mechanisms of synaptic integration and strength regulation for improved performance of both artificial and spiking neural networks.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Wei Wen, Gina G. Turrigiano
Summary: Homeostatic plasticity in neural circuits can be modulated differently at various developmental stages, with excitatory synaptic scaling and intrinsic homeostatic plasticity being induced during critical periods but only excitatory synaptic scaling persisting into adulthood. This suggests that distinct sets of homeostatic plasticity mechanisms are recruited based on the needs of the developing neural circuit.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Natalie Rauter
Summary: Accurately predicting the deformation behavior of components made of short fiber-reinforced composites is crucial for numerical simulations. This study successfully incorporated probabilistic information using random fields and accurately predicted the elastic and plastic deformation behavior of tensile test specimens made of short fiber-reinforced composites.
APPLIED SCIENCES-BASEL
(2022)
Article
Cell Biology
Xiao-Yan Shen, Chun-Ling Tao, Lei Ma, Jia-Huan Shen, Zhi-Ling Li, Zhi-Gong Wang, Xiao-Ying Lue
Summary: This study identified the migration patterns of core regions for hip flexion and extension following spinal cord injury in rat models, providing valuable insights for spinal electrode implantation post-injury.
NEURAL REGENERATION RESEARCH
(2021)
Review
Neurosciences
Albert M. Galaburda
Summary: This paper provides a brief review of two endophenotypes associated with developmental dyslexia, namely cerebral lateralization and cerebrocortical dysfunction, and describes the animal work done to shed light on the etiology and neural mechanisms of developmental dyslexia. It also considers future directions of research.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Shen Tian, Antonia Monteiro
Summary: Organisms in regions with alternating seasons develop different phenotypes in each season, which are adaptations to the environment. This study investigates how gene expression, alternative splicing, and miRNA-mediated gene silencing vary in Bicyclus anynana butterfly hindwing tissue at different developmental timepoints and rearing temperatures. The results suggest that developmental transitions and hormone pulses have a greater impact on transcriptomic patterns than rearing temperatures. The study also identifies differentially expressed genes, differentially spliced genes, and miRNA-regulated genes between the seasonal forms.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Article
Medicine, General & Internal
Heather T. Keenan, Amy Clark, Rich Holubkov, Linda Ewing-Cobbs
Summary: This study evaluated the development of infants and toddlers with traumatic brain injury (TBI) over a 3-year period compared to those with orthopedic injury (OI). The findings showed that children with severe TBI had limited recovery, while those with mild or moderate TBI performed similarly to those with OI. Early intervention is crucial for children with severe TBI, while routine developmental surveillance is recommended for children with milder injuries.
Article
Anatomy & Morphology
Volker A. Coenen, Mate D. Doebroessy, Shi Jia Teo, Johanna Wessolleck, Bastian E. A. Sajonz, Peter C. Reinacher, Annette Thierauf-Emberger, Bjoern Spittau, Jochen Leupold, Dominik von Elverfeldt, Thomas E. Schlaepfer, Marco Reisert
Summary: Recent uncertainties have arisen regarding the anatomy and function of cortico-subcortical projections, particularly the distinction between cortico-subthalamic (hyperdirect) and cortico-tegmental projections (slMFB). Deep Brain Stimulation of the slMFB has been found to impact not only reward-associated pathways but other structures as well. This research clarifies the co-existence of slMFB and prefrontal hyperdirect pathways, supporting the efficacy of slMFB DBS in treating MD and OCD.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Computer Science, Interdisciplinary Applications
Sean M. Rothenberger, Jiacheng Zhang, Melissa C. Brindise, Susanne Schnell, Michael Markl, Pavlos P. Vlachos, Vitaliy L. Rayz
Summary: We present a model to estimate the bias error of 4D flow MRI velocity measurements, accounting for intra-voxel velocity distribution and partial volume effects. The model accurately estimates the bias error in voxels not affected by partial volume effects, and can help plan 4D flow MRI scans.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Simin Mahinrad, Can Ozan Tan, Yue Ma, Maria Aristova, Andrew L. Milstead, Donald Lloyd-Jones, Susanne Schnell, Michael Markl, Farzaneh A. Sorond
Summary: The study aimed to compare cerebral blood flow velocity measures derived from dual-venc 4D flow MRI and TCD. The results showed excellent interobserver agreement in dual-venc 4D flow MRI-based measurements of peak velocity, with a slight underestimation compared to TCD.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Chemistry, Multidisciplinary
Andreas B. Schmidt, Mirko Zimmermann, Stephan Berner, Henri de Maissin, Christoph A. Mueller, Vladislav Ivantaev, Juergen Hennig, Dominik Elverfeldt, Jan-Bernd Hoevener
Summary: This study demonstrates the virtually continuous production of highly-hyperpolarized carbon-13 contrast agents within an MRI system every 15 seconds, without the need for a stand-alone polarizer. The authors addressed the challenges of efficient spin-order transfer and synchronized cycling of chemicals and reactions to achieve polarization levels of approximately 2% and 19% for various contrast agents. This Rapid-PHIP technique promises fast preclinical studies and repeated administration.
COMMUNICATIONS CHEMISTRY
(2022)
Article
Neurosciences
Laetitia Degiorgis, Tanzil Mahmud Arefin, Sami Ben-Hamida, Vincent Noblet, Cristina Antal, Thomas Bienert, Marco Reisert, Dominik von Elverfeldt, Brigitte L. Kieffer, Laura-Adela Harsan
Summary: This study establishes brain-wide fingerprints of alcohol effects in mice using structural and functional magnetic resonance imaging and connectome mapping. The findings show that alcohol affects both brain structure and function, and provide insights into the impact of alcohol on inflammation and different brain networks.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pamela Franco, Liliana Ma, Susanne Schnell, Hugo Carrillo, Cristian Montalba, Michael Markl, Cristobal Bertoglio, Sergio Uribe
Summary: This study developed a correction method for the ODV approach and compared it with other methods. Statistical analysis showed significant differences in the impact of unwrapping methods on noise levels, with unwrapping methods being more robust to noise for beta = VENCL/VENCH = 1/2. The ODV corrected method performed better in terms of noise robustness but had a longer computational time.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maria Aristova, Jianing Pang, Yue Ma, Liliana Ma, Haben Berhane, Vitaliy Rayz, Michael Markl, Susanne Schnell
Summary: Variable Spatial Resolution Dual Venc (VSRDV) 4D flow MRI reduces scan time and enables accurate neurovascular flow characterization with wide spatial coverage and dynamic range.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Octavia Bane, Daniel Stocker, Paul Kennedy, Stefanie J. Hectors, Emilie Bollache, Susanne Schnell, Thomas Schiano, Swan Thung, Aaron Fischman, Michael Markl, Bachir Taouli
Summary: This study demonstrated the feasibility of a free-breathing, spatio-temporal accelerated 4D flow MRI acquisition for flow quantification in abdominal vessels. The accelerated acquisition was faster and showed good consistency in vessel identification and average flow compared to the standard respiratory-triggered acquisition.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Adhara Lazaro, Patrick Stoll, Dominik von Elverfeldt, Wolfgang Kreisel, Peter Deibert
Summary: This study investigated the potential correlation between mean arterial pressure (MAP) and portal venous pressure (PVP) in rats with healthy livers. The results showed that changes in MAP are followed by changes in PVP with a distinct time lag, indicating a cause-and-effect relationship. The study also revealed that Sildenafil influences portal pressure. Further studies should be conducted in a model with cirrhotic livers to evaluate the effects of vasoactive drugs for therapy of portal hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Adrienne E. Campbell-Washburn, Kathryn E. Keenan, Peng Hu, John P. Mugler, Krishna S. Nayak, Andrew G. Webb, Johnes Obungoloch, Kevin N. Sheth, Juergen Hennig, Matthew S. Rosen, Najat Salameh, Daniel K. Sodickson, Joel M. Stein, Jose P. Marques, Orlando P. Simonetti
Summary: The first ISMRM Workshop on Low-Field MRI was held virtually in March 2022, discussing recent advancements in low field MRI technology and its clinical applications. With 368 registrants from 24 countries, the workshop included invited talks, abstract presentations, panel discussions, and live scanner demonstrations. The workshop emphasized the potential of low-field MRI in expanding MRI usage through cost reduction, portability, and ease of installation, as well as the challenges in overcoming SNR limitations and establishing clinical value.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Computer Science, Interdisciplinary Applications
Sean M. Rothenberger, Neal M. Patel, Jiacheng Zhang, Susanne Schnell, Bruce A. Craig, Sameer A. Ansari, Michael Markl, Pavlos P. Vlachos, Vitaliy L. Rayz
Summary: We propose an automatic segmentation method for 4D flow MRI based on SDM velocity. The SDM velocity quantifies the net flow effects in each voxel, and vessel segmentation is performed using an F-test. We compare the SDM algorithm with PCD and CNN segmentation methods, and the results demonstrate its robustness and accuracy in identifying vessel surfaces.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Article
Computer Science, Artificial Intelligence
E. Ferdian, D. Marlevi, J. Schollenberger, M. Aristova, E. R. Edelman, S. Schnell, C. A. Figueroa, D. A. Nordsletten, A. A. Young
Summary: The development of cerebrovascular disease is closely related to changes in intracranial flow and pressure. We developed a two-step approach using a deep residual network and physics-informed image processing to non-invasively quantify cerebrovascular hemodynamics. Our method showed good accuracy in estimating velocity and flow, as well as quantifying functional relative pressures. Additionally, we successfully applied our method to in-vivo volunteers, generating high-resolution intracranial flow images and reducing low-resolution bias in pressure estimation.
MEDICAL IMAGE ANALYSIS
(2023)
Review
Cardiac & Cardiovascular Systems
Malenka M. Bissell, Francesca Raimondi, Lamia Ait Ali, Bradley D. Allen, Alex J. Barker, Ann Bolger, Nicholas Burris, Carl-Johan Carhaell, Jeremy D. Collins, Tino Ebbers, Christopher J. Francois, Alex Frydrychowicz, Pankaj Garg, Julia Geiger, Hojin Ha, Anja Hennemuth, Michael D. Hope, Albert Hsiao, Kevin Johnson, Sebastian Kozerke, Liliana E. Ma, Michael Markl, Duarte Martins, Marci Messina, Thekla H. Oechtering, Pim van Ooij, Cynthia Rigsby, Jose Rodriguez-Palomares, Arno A. W. Roest, Alejandro Roldan-Alzate, Susanne Schnell, Julio Sotelo, Matthias Stuber, Ali B. Syed, Johannes Toeger, Rob van der Geest, Jos Westenberg, Liang Zhong, Yumin Zhong, Oliver Wieben, Petter Dyverfeldt
Summary: This consensus paper provides an updated overview of the importance of four-dimensional cardiovascular magnetic resonance flow imaging (4D Flow CMR) in the diagnosis and management of cardiovascular disease. It discusses sequence options, imaging considerations, acquisition parameters, post-processing workflows, and integration into clinical practice. The paper also defines quality assurance and validation standards for clinical centers, addresses challenges in the research setting, and includes a checklist for publication standards.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Juergen Hennig
Summary: The paper details the evolution of low-field MRI from its inception to present day, focusing on the differences in research environments. In the early 90s, the lack of reasonable means to compensate for the difference in signal-to-noise ratio between 0.5 and 1.5 T resulted in the disappearance of low-field systems. However, advancements in hardware, RF receiver systems, faster gradients, flexible sampling schemes, and the integration of AI have made low-field MRI a clinically viable supplement. Additionally, ultralow-field MRI with magnets around 0.05 T has emerged as an endeavor to bring MRI to underserved communities.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2023)