Review
Biotechnology & Applied Microbiology
Yun-Feng Zhou, Di Zhang, Wan-Ting Yan, Kai Lian, Zheng-Zheng Zhang
Summary: This article reviews the therapeutic potential of multipotent stromal cells (MSCs) in repairing meniscal injuries and discusses the avenues for utilizing these cells. The current progress on biomaterial implants is also reviewed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Nanoscience & Nanotechnology
Hanieh Shokrani, Amirhossein Shokrani, S. Mohammad Sajadi, Farzad Seidi, Amin Hamed Mashhadzadeh, Navid Rabiee, Mohammad Reza Saeb, Tejraj Aminabhavi, Thomas J. Webster
Summary: This review article summarizes various natural and synthetic scaffolds that support angiogenesis, as well as cell sources and influential factors for angiogenesis with a focus on biomechanical and other stimulatory factors. The article points out that the selection of the best biomaterial and cells remains a contentious area, and highlights parameters that need to be addressed in future studies.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Yucai Wang, Guangfu Wang, Hao Liu
Summary: This study provides a comprehensive review of the dynamic changes and functions of Tenascin-C (TNC) during tissue regeneration. The review highlights the multiple mechanisms of TNC at different stages of restoration, with a specific emphasis on its role in angiogenesis and wound healing.
Article
Biochemistry & Molecular Biology
Marc Elosua-Bayes, Paula Nieto, Elisabetta Mereu, Ivo Gut, Holger Heyn
Summary: SPOTlight is a computational tool that integrates spatial transcriptomics with single-cell RNA sequencing data to infer the location of cell types and states within complex tissues. Its high prediction accuracy and flexible application spectrum were demonstrated through applications in mouse brain and human pancreatic cancer.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Yaru Guo, Siqin Ma, Mingming Xu, Yan Wei, Xuehui Zhang, Ying Huang, Ying He, Boon Chin Heng, Lili Chen, Xuliang Deng
Summary: Angiogenesis is crucial in tissue engineering and regenerative medicine, and the interplay between ECs and the ECM plays a significant role in tip cell specification. HtrA3 protein is shown to be involved in this process, promoting tip cell morphogenesis through ECM degradation and integrin beta 1-related signaling pathways. This study suggests that HtrA3 could potentially serve as a therapeutic agent for enhancing angiogenesis and targeting pathological angiogenesis.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Multidisciplinary Sciences
Shiv Shah, Caldon Jayson Esdaille, Maumita Bhattacharjee, Ho-Man Kan, Cato T. Laurencin
Summary: Stem cells have the ability to regulate the local microenvironment by secreting bioactive factors, making them a promising approach for tissue regeneration. Researchers have developed a synthetic artificial stem cell system that mimics the paracrine effect of stem cell secretome, providing a customizable treatment for targeted tissue regeneration. In experiments treating osteoarthritis, the synthetic stem cell system showed significant anti-inflammatory and chondroprotective effects both in vitro and in vivo, demonstrating its potential as a new therapeutic strategy for tissue engineering applications.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biology
Chih-Wei Zeng
Summary: Spinal cord injury (SCI) has a significant impact on quality of life, necessitating new treatment options. Multipotent mesenchymal stem cells (MSCs) have emerged as a promising candidate for SCI treatment due to their regenerative capabilities. This comprehensive review discusses the molecular mechanisms involved in MSC-mediated tissue repair in SCI. It also examines various clinical applications of MSCs in SCI treatment, and highlights the challenges associated with MSC-based therapies.
Article
Engineering, Biomedical
Yaru Guo, Feng Mei, Ying Huang, Siqin Ma, Yan Wei, Xuehui Zhang, Mingming Xu, Ying He, Boon Chin Heng, Lili Chen, Xuliang Deng
Summary: This study demonstrates that matrix stiffness promotes sprouting of endothelial cells and regulates the formation of tip cells through a specific signaling axis. The findings have significant implications for biomaterial design and treatment of pathological conditions.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Saik-Kia Goh, Willi Halfter, Thomas Richardson, Suzanne Bertera, Vimal Vaidya, Joe Candiello, Mahalia Bradford, Ipsita Banerjee
Summary: Pluripotent stem cells can differentiate through interactions with extracellular matrix. ECM plays a crucial role in regulating the function and fate of stem cells. Replicating the native ECM microenvironment using decellularized organ-derived ECM can promote tissue-specific cellular development and maturation.
Article
Biochemistry & Molecular Biology
Qichen Peng, Ruimin Guo, Yangyang Zhou, Ruidi Teng, Yulin Cao, Shiqing Mu
Summary: Endothelialization is crucial for the healing of aneurysms after endovascular treatment, and MSC-seeded stents have the potential to promote aneurysm repair. This study investigates the effects of MSC-seeded nitinol intracranial stents with different coatings on vascular cells, macrophage proliferation, and inflammation. The G/PLL coating enhances cell adhesion and proliferation, as well as MSC secretion and regulation of vascular cells and macrophage chemotaxis. On the other hand, the SF/SDF-1 alpha coating promotes MSC secretion and vascular cell chemotaxis but induces a greater level of macrophage proliferation, chemotaxis, and pro-inflammatory factor secretion.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Engineering, Biomedical
Christopher J. Panebianco, Sanjna Rao, Warren W. Hom, James H. Meyers, Tiffany Y. Lim, Damien M. Laudier, Andrew C. Hecht, Michael D. Weir, Jennifer R. Weiser, James C. Iatridis
Summary: This study developed an injectable composite biomaterial using degradable oxidized alginate microbeads for delivering annulus fibrosus cells to injured intervertebral discs. The composite material achieved a balance between biomechanical and biological demands, providing promising results for cell delivery and repair.
Article
Engineering, Biomedical
Ross E. B. Fitzsimmons, Ronald G. Ireland, Aileen Zhong, Agnes Soos, Craig A. Simmons
Summary: One approach to engineering viable tissues ex vivo involves using hydrogel-based microfluidics to generate microvessels, with a focus on collagen, fibrin, and collagen-fibrin co-gel formulations. Fibrin and co-gels were found to promote multicellular EC sprouting, while collagen required supplementation to elicit a migration response. Increasing collagen content in co-gel formulations led to higher compressive modulus and reliable formation of intact hydrogel-based microchannels for perfusion, making collagen-fibrin co-gels a promising option for generating vascularized tissue constructs.
BIOMEDICAL MATERIALS
(2021)
Article
Multidisciplinary Sciences
Angelina Schindele, Fabienne Gehrke, Carla Schmidt, Sarah Roehrig, Annika Dorn, Holger Puchta
Summary: CRISPR/Cas is mainly used for mutagenesis, but this study shows that induction of cell death can be achieved using the SaCas9 nuclease, referred to as CRISPR-Kill, for tissue engineering. By replacing the promoter, organogenesis can be blocked and specific traits can be targeted, such as eliminating petals and reducing lateral root numbers and length. CRISPR-Kill may have implications not only for controlling development but also altering biochemical properties of plants.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Giulia Battistelli, Maria Proetto, Alexandra Mavridi-Printezi, Matteo Calvaresi, Alberto Danielli, Paolo Emidio Constantini, Claudia Battistella, Nathan C. Gianneschi, Marco Montalti
Summary: Fluorogenic nanoparticles that can respond to different physiological environments and differentially release drugs have great potential in nanomedicine. pH-responsive NPs, especially, have the ability to distinguish cancer tissues, release drugs selectively, and act as pH biosensors. The assembly of ROMP block-copolymers provides a solid route for the design and synthesis of pH-responsive fluorogenic micelles. This approach shows promise in the development of novel nano-theranostic agents.
Article
Materials Science, Biomaterials
Zhen An, Liwei Zhang, Yuanshan Liu, Hongbo Zhao, Yajie Zhang, Yi Cao, Ye Zhang, Renjun Pei
Summary: This study developed a ROS-responsive injectable polyethylene glycol hydrogel containing thioketal bonds to deliver epidermal growth factor (EGF), effectively scavenging excessive ROS and controlling EGF release for wound regeneration. The EGF@PEG-TK hydrogel treatment showed benefits in protecting cells from oxidative stress, accelerating wound closure, and reducing scar formation in full-thickness skin defects, providing a promising strategy for antioxidant hydrogel dressing to facilitate wound repair.
BIOMATERIALS SCIENCE
(2021)
Article
Engineering, Biomedical
Arun K. Sharma, Partha V. Hota, Derek J. Matoka, Natalie J. Fuller, Danny Jandali, Hatim Thaker, Guillermo A. Ameer, Earl Y. Cheng
Article
Engineering, Biomedical
Matthew I. Bury, Natalie J. Fuller, Jay W. Meisner, Matthias D. Hofer, Matthew J. Webber, Lesley W. Chow, Sheba Prasad, Hatim Thaker, Xuan Yue, Vani S. Menon, Edward C. Diaz, Samuel I. Stupp, Earl Y. Cheng, Arun K. Sharma
Article
Medicine, General & Internal
Yong Zhao, Zhaoshun Jiang, Tingbao Zhao, Mingliang Ye, Chengjin Hu, Huimin Zhou, Zhaohui Yin, Yana Chen, Ye Zhang, Shanfeng Wang, Jie Shen, Hatim Thaker, Summit Jain, Yunxiang Li, Yalin Diao, Yingjian Chen, Xiaoming Sun, Mary Beth Fisk, Heng Li
Review
Cell & Tissue Engineering
Hatim Thaker, Arun K. Sharma
STEM CELLS INTERNATIONAL
(2012)
Article
Pediatrics
Sila Kurugol, Catherine M. Seager, Hatim Thaker, Jaume Coll-Font, Onur Afacan, Reid C. Nichols, Simon K. Warfield, Richard S. Lee, Jeanne S. Chow
JOURNAL OF PEDIATRIC UROLOGY
(2020)
Review
Pediatrics
Hatim Thaker, Caleb P. Nelson
JOURNAL OF PEDIATRIC UROLOGY
(2020)
Article
Microbiology
Hatim Thaker, Jie Zhang, Shin-Ichiro Miyashita, Vivian Cristofaro, SunHyun Park, Ali Hashemi-Gheinani, Maryrose P. Sullivan, Rosalyn M. Adam, Min Dong
Summary: This study demonstrated that Syt2 is the dominant receptor for BoNT/B, DC, and G at skeletal muscle neuromuscular junctions, while Syt1 is the primary toxin receptor in the autonomic nerves controlling bladder tissues. These findings validate the critical role of protein receptors for the potency and specificity of BoNTs in vivo.
Article
Andrology
Chase G. Clemesha, Hatim Thaker, Mary K. Samplaski
WORLD JOURNAL OF MENS HEALTH
(2020)
Article
Urology & Nephrology
Hatim Thaker, Saum Ghodoussipour, Mateen Saffarian, Akbar Ashrafi, Gus Miranda, Jie Cai, Anne K. Schuckman, Monish Aron, Mihir Desai, Inderbir S. Gill, Siamak Daneshmand, Hooman Djaladat
CANADIAN JOURNAL OF UROLOGY
(2019)
Article
Pediatrics
Hatim Thaker, Isuru S. Jayaratna, Zein K. Nakhoda, Jenny Jaque, Andy Y. Chang
PEDIATRIC INVESTIGATION
(2018)