Article
Multidisciplinary Sciences
Stephane Pages, Nicolas Chenouard, Ronan Chereau, Vladimir Kouskoff, Frederic Gambino, Anthony Holtmaat
Summary: The organization and plasticity of cortical sensory maps depend on experience, particularly on the role of higher-order thalamocortically mediated plateau potentials in whisker map plasticity. Blocking the plateau potentials can restore the typical organization of sensory maps.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
John B. B. Butcher, Robert E. E. Sims, Neville M. M. Ngum, Amjad H. H. Bazzari, Stuart I. I. Jenkins, Marianne King, Eric J. J. Hill, David A. A. Nagel, Kevin Fox, H. Rheinallt Parri, Stanislaw Glazewski
Summary: Changes in sensory experience can lead to plasticity of synapses in the cortex, and astrocytes play a crucial role in this process. Experiments on mice showed that the lack of astrocyte-expressed IP3 receptor subtype affected experience-dependent plasticity, and changes in astrocytic [Ca2+](i) concentration can switch the synaptic plasticity mechanisms.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Julie Fourneau, Marie-Helene Canu, Erwan Dupont
Summary: This study investigated the synaptic plasticity process in the somatosensory primary cortex during a period of sensorimotor perturbation and recovery. The results showed that changes in the presynaptic compartment occurred as early as D7 during SMP, followed by changes in the postsynaptic compartment at D14, and these changes persisted at least until 24 hours of recovery. Proteins related to synapse structure were mildly affected, primarily at D14.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Nerea Llamosas, Sheldon D. Michaelson, Thomas Vaissiere, Camilo Rojas, Courtney A. Miller, Gavin Rumbaugh
Summary: The Syngap1 gene promotes experience-dependent excitatory synapse strengthening in the mouse cortex, while synaptic depression and bouton elimination are unaffected. It enhances somatic neural activity in weakly active neurons within cortical networks, but has little impact on highly active neurons.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Norbert Hogrefe, Sigrid M. Blom, Kristina Valentinova, Niels R. Ntamati, Lotte J. E. Jonker, Natalie E. Nevian, Thomas Nevian
Summary: Malfunctioning synaptic plasticity is a major mechanism in the development of chronic pain. This study shows that even after recovery, the impact of chronic compression injury on synaptic plasticity persists.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Monika Zareba-Koziol, Anna Bartkowiak-Kaczmarek, Matylda Roszkowska, Krystian Bijata, Izabela Figiel, Anup Kumar Halder, Paulina Kaminska, Franziska E. Mueller, Subhadip Basu, Weiqi Zhang, Evgeni Ponimaskin, Jakub Wlodarczyk
Summary: Sex differences in the brain are associated with differences in neuronal morphology, synaptic plasticity, and molecular signaling pathways. S-PALM mechanism plays a crucial role in regulating synaptic integrity and neuronal signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Santiago Rodriguez Ospina, Danielle M. Blazier, Marangelie Criado-Marrero, Lauren A. Gould, Niat T. Gebru, David Beaulieu-Abdelahad, Xinming Wang, Elizabeth Remily-Wood, Dale Chaput, Stanley Stevens, Vladimir N. Uversky, Paula C. Bickford, Chad A. Dickey, Laura J. Blair
Summary: The study found that overexpression of Hsp22 can protect synaptic plasticity and cognition in tauopathic brains, without significantly altering tau phosphorylation levels. Mass spectrometry analysis revealed that Hsp22 overexpression in neurons promotes synaptic plasticity by regulating canonical pathways and upstream regulators related to potential AD markers and synaptogenesis regulators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Alberto Lazari, Piergiorgio Salvan, Michiel Cottaar, Daniel Papp, Matthew F. S. Rushworth, Heidi Johansen-Berg
Summary: Evidence suggests that white matter plasticity in humans follows Hebb's rule. Stimulation of cortical areas leads to increased cortical excitability and a myelin marker in the stimulated fiber bundle, indicating the presence of Hebbian plasticity in human white matter fibers.
Article
Cell Biology
Lilyana D. Quigley, Robert Pendry, Matthew L. Mendoza, Brad. E. Pfeiffer, Lenora J. Volk
Summary: Synaptic plasticity is hypothesized to contribute to the replay of salient experience during hippocampal SWR-based ensemble activity and facilitate memory consolidation. The synaptic protein KIBRA regulates plasticity and memory. Through studying WT and KIBRA cKO mice, it was found that KIBRA deletion disrupted experience-induced alterations in SWRs and hippocampal-cortical communication during SWRs.
Article
Cell Biology
Qian Qiao, Chunling Wu, Lei Ma, Hua Zhang, Miao Li, Xujun Wu, Wen-Biao Gan
Summary: Learning induces the formation of new synapses, which are preferentially active and synchronized with dendritic/somatic activity during the execution of learned tasks. These new synapses increase the task specificity of neurons and are not affected by learning new tasks.
Article
Biochemistry & Molecular Biology
Lia Forti, Elona Ndoj, Jessica Mingardi, Emanuele Secchi, Tiziana Bonifacino, Emanuele Schiavon, Giulia Carini, Luca La Via, Isabella Russo, Marco Milanese, Massimo Gennarelli, Giambattista Bonanno, Maurizio Popoli, Alessandro Barbon, Laura Musazzi
Summary: Traumatic stress is a significant risk factor for psychiatric disorders. This study investigates the effects of acute footshock stress and ketamine on the glutamatergic synaptic plasticity in the prefrontal cortex. The findings suggest that acute stress and ketamine induce changes in dopamine-dependent long-term potentiation (LTP) as well as ionotropic glutamate receptor subunit expression and localization. Further research is needed, but this initial report supports the potential benefit of acute ketamine in mitigating the impact of acute traumatic stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
P. Hayley, C. Tuchek, S. Dalla, J. Borrell, M. D. Murphy, R. J. Nudo, D. J. Guggenmos
Summary: This study aims to investigate the crosstalk between sensorimotor cortical areas and its relationship with recovery. The results suggest that even with damage to the primary motor cortex, sensory stimulation can still elicit neural activity in the motor cortex, and stimulation in the motor cortex can modulate the sensory response in the sensory cortex.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Wei Sun, Xiao Chen, Yazi Mei, Yang Yang, Xiaoliang Li, Lei An
Summary: Fear regulation changes as a function of early life, and the involvement of prelimbic proBDNF in fear memory extinction and its mediated signaling have been investigated. By activating p75(NTR)-GluN2B signaling, high levels of prelimbic proBDNF enhance the destabilization of retrieval-dependent weak fear memory. This modification is attributed to the promotion of synaptic function and an increase in the proportion of thin-type spines. Furthermore, strong prelimbic theta- and gamma-oscillation coupling predicts the suppressive effect of juvenile proBDNF on the recall of postretrieval memory.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Behavioral Sciences
Elena Amoruso, Devin B. Terhune, Maria Kromm, Stephen Kirker, Dollyane Muret, Tamar R. Makin
Summary: Studies have shown that amputees and individuals with congenital one-handers can perceive facial touch as arising from their phantom hand, but this perception is not necessarily related to cortical plasticity. This study investigated the influence of demand characteristics on referred sensations reports, and found that the stimulation methods and frequency of referred sensations were similar in amputees and control groups.
Article
Neurosciences
Sebastian M. Frank, Alexandra Otto, Gregor Volberg, Peter U. Tse, Takeo Watanabe, Mark W. Greenlee
Summary: This study demonstrates that tactile learning can transfer to untrained body parts that are coactivated with the trained body part. The researchers found that the transfer of tactile learning was greater from the trained foot to the untrained hand compared to the other way around. The results suggest that the neural mechanisms underlying tactile learning involve somatotopic representation in the primary somatosensory cortex.
JOURNAL OF NEUROSCIENCE
(2022)