期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 110, 期 51, 页码 20581-20586出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1313696110
关键词
in vivo imaging; islet grafts; beta cell mass; ob/ob mouse; pharmacologic treatment
资金
- Wenner-Gren Foundation and Karolinska Institutet
- Juvenile Diabetes Research Foundation [3-2007-73]
- European Foundation for the Study of Diabetes/Merck Sharp & Dohme Research Program
- Swedish Research Council
- Swedish Diabetes Association
- Swedish Society for Medical Research
- Novo Nordisk Foundation
- Strategic Research Program in Diabetes at Karolinska Institutet
- European Union [FP7-228933-2]
- Knut and Alice Wallenberg Foundation
- Erling-Persson Family Foundation
- Stichting af Jochnick Foundation
- Berth von Kantzow's Foundation
- Diabetes Research Wellness Foundation
- World Class University Program through the National Research Foundation of Korea
- Ministry of Education, Science, and Technology [R31-2008-000-10105-0]
- Skandia Insurance Company, Ltd.
- Novo Nordisk Fonden [NNF12OC1016557] Funding Source: researchfish
The islets of Langerhans constitute the endocrine part of the pancreas and are responsible for maintenance of blood glucose homeostasis. They are deeply embedded in the exocrine pancreas, limiting their accessibility for functional studies. Understanding regulation of function and survival and assessing the clinical outcomes of individual treatment strategies for diabetes requires a monitoring system that continuously reports on the endocrine pancreas. We describe the application of a natural body window that successfully reports on the properties of in situ pancreatic islets. As proof of principle, we transplanted reporter islets into the anterior chamber of the eye of leptin-deficient mice. These islets displayed obesity-induced growth and vascularization patterns that were reversed by leptin treatment. Hence, reporter islets serve as optically accessible indicators of islet function in the pancreas, and also reflect the efficacy of specific treatment regimens aimed at regulating islet plasticity in vivo.
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