期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 110, 期 9, 页码 3561-3566出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1212907110
关键词
chloride; GABA
资金
- Canadian Institutes of Health Research [MOP-7315, IOP-54037]
- Natural Sciences and Engineering Research Council (Canada)
KCC2 is a neuron-specific K+ -Cl- cotransporter that is essential for Cl- homeostasis and fast inhibitory synaptic transmission in the mature CNS. Despite the critical role of KCC2 in neurons, the mechanisms regulating its function are not understood. Here, we show that KCC2 is critically regulated by the single-pass transmembrane protein neuropilin and tolloid like-2 (Neto2). Neto2 is required to maintain the normal abundance of KCC2 and specifically associates. with the active oligomeric form of the transporter. Loss of the Neto2:KCC2 interaction reduced KCC2-mediated Cl extrusion, resulting in decreased synaptic inhibition in hippocampal neurons.
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