Review
Biochemistry & Molecular Biology
Yi-Chen Shen, Xiao Sun, Lei Li, Hu-Yunlong Zhang, Zhi-Li Huang, Yi-Qun Wang
Summary: Sleep and wakefulness are fundamental behavioral states that involve coordination between brain regions and multiple neurochemical systems, including neuropeptides. Neuropeptides, produced by neurons and neuroendocrine cells, can bind to specific receptors and regulate neuronal activities. Different neuropeptides play distinct roles in sleep-wake regulation, promoting sleep, inducing wakefulness, or having bidirectional effects. This review provides an overview of the distribution of neuropeptides in the brain and summarizes their roles in sleep-wake regulation, aiming to lay the foundation for further studies on the mechanisms underlying sleep-wake states.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Lukas B. Krone, Tomoko Yamagata, Cristina Blanco-Duque, Mathilde C. C. Guillaumin, Martin C. Kahn, Vincent van der Vinne, Laura E. McKillop, Shu K. E. Tam, Stuart N. Peirson, Colin J. Akerman, Anna Hoerder-Suabedissen, Zoltan Molnar, Vladyslav V. Vyazovskiy
Summary: The cortex is shown to play a significant role in both global state control and sleep homeostasis, particularly in vigilance state control and recovery after sleep deprivation.
NATURE NEUROSCIENCE
(2021)
Article
Clinical Neurology
Anastasis Georgoulas, Laura Jones, Maria Pureza Laudiano-Dray, Judith Meek, Lorenzo Fabrizi, Kimberley Whitehead
Summary: In this study of 175 infants, unique regulation of sleep-wake states was observed, with particularly long durations of active sleep. Stress and nociception were found to impact sleep durations, especially in preterm infants, highlighting the importance of environmental interventions in promoting healthy sleep patterns.
Article
Cell Biology
Wanling Peng, Xiaotong Liu, Guofen Ma, Zhaofa Wu, Ziyue Wang, Xiang Fei, Meiling Qin, Lizhao Wang, Yulong Li, Siyu Zhang, Min Xu
Summary: Astrocyte Ca2+ activity can regulate sleep-wake behavior without the involvement of adenosine signaling. Although astrocyte Ca2+ levels correlate with extracellular adenosine, suppressing astrocyte Ca2+ elevation does not lead to a change in adenosine level. Neural activity-dependent astrocyte activity primarily regulates sleep-wake cycle in specific brain regions. Hence, astrocyte activity can modulate sleep-wake behavior independent of adenosine signaling.
Article
Computer Science, Artificial Intelligence
Csongor Varady, Riccardo Volpi, Luigi Malago, Nihat Ay
Summary: This paper introduces the algorithms NRWS and NBiHM, based on natural gradient, for efficient training of generative models HMs. The experimental results show significant improvements in terms of convergence speed and log-likelihood compared to non-geometric baselines and state-of-the-art training algorithms for HMs.
Article
Mathematics, Applied
Mustafa Sayli, Anne C. Skeldon, Rudiger Thul, Rachel Nicks, Stephen Coombes
Summary: The two-process model introduced by Borbely has been used to explain sleep-wake regulation in various species, including humans, for the past four decades. This model represents circadian and homeostatic processes with a one-dimensional nonautonomous and nonsmooth flow, where the rate of change of homeostatic sleep pressure switches at specific times. By analyzing the underlying nonsmooth flow, this study provides an equivalent description and a more detailed understanding of the model's periodic orbits and instabilities. The authors also propose using techniques from nonsmooth dynamical systems to study networks of the two-process model, considering the continuous interactions throughout the day-night cycle.
PHYSICA D-NONLINEAR PHENOMENA
(2023)
Article
Chemistry, Multidisciplinary
Karim Fifel, Masashi Yanagisawa, Tom Deboer
Summary: Sleep/wake alterations are predominant in neurological and neuropsychiatric disorders involving dopamine dysfunction. This study investigates the pathophysiological mechanisms of sleep/wake alterations within a hypodopaminergic MitoPark mouse model of Parkinson's disease (PD). The findings suggest that the sleep phenotype is linked to the impairment of instrumental arousal and sleep modulation by behavioral valence.
Review
Pharmacology & Pharmacy
Yo Oishi, Yuki C. Saito, Takeshi Sakurai
Summary: Benzodiazepine enhances the activity of GABAA receptors and is commonly used to treat insomnia, highlighting the importance of GABAergic neurotransmission in sleep. Recent research, including the review discussed here, focuses on the involvement of GABAergic neurons in the regulation of sleep-wake cycles, specifically in the preoptic area (POA) and ventral tegmental area (VTA). This emphasizes the significance of GABAergic neurotransmission in these regions for the regulation of sleep-wake cycles.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Clinical Neurology
Carolin Franziska Reichert, Tom Deboer, Hans-Peter Landolt
Summary: This review examines the current state of research on the effects of adenosine and caffeine on sleep, focusing on their mechanisms of action and influence on sleep homeostasis and the circadian clock. The potential clinical applications of this knowledge are discussed, along with unanswered questions that require further investigation.
JOURNAL OF SLEEP RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Jose Manuel Duhart, Sho Inami, Kyunghee Koh
Summary: The two-process model of sleep regulation has been a dominant conceptual framework for sleep research. In addition to the circadian and homeostatic processes, sleep is influenced by various factors such as essential behaviors, sensory inputs, and memory consolidation.
Review
Immunology
Daniela Latorre, Sallusto Federica, Claudio L. A. Bassetti, Ulf Kallweit
Summary: Narcolepsy is a chronic neurological disorder characterized by excessive daytime sleepiness and cataplexy. Diagnosis and treatment of the disease remain challenging due to its clinical heterogeneity and lack of understanding of its underlying mechanisms. However, significant progress has been made in recent years, opening new perspectives for the field.
SEMINARS IN IMMUNOPATHOLOGY
(2022)
Article
Multidisciplinary Sciences
Aditi Pophale, Kazumichi Shimizu, Tomoyuki Mano, Teresa L. Iglesias, Kerry Martin, Makoto Hiroi, Keishu Asada, Paulette Garcia Andaluz, Thi Thu Van Dinh, Leenoy Meshulam, Sam Reiter
Summary: Octopuses exhibit two stages of sleep, quiet sleep and active sleep. Active sleep is characterized by body movements and changes in skin patterning similar to wakefulness. Quiet sleep is characterized by brain activity and specific brain regions resembling mammalian sleep, suggesting convergent features of complex cognition.
Article
Clinical Neurology
Vidhya Vijayakrishnan Nair, Brianna R. Kish, Pearlynne L. H. Chong, Ho-Ching (Shawn) Yang, Yu-Chien Wu, Yunjie Tong, A. J. Schwichtenberg
Summary: This study examines the movement of cerebrospinal fluid (CSF) during sleep and its relationship with neuronal-driven and non-neuronal systemic physiology driven movement. The findings suggest that interventions targeting NREM sleep and manipulating systemic physiology may increase CSF movement.
Article
Sport Sciences
Melanie Knufinke, Arne Nieuwenhuys, Sabine A. E. Geurts, Els I. S. Most, Maarten H. Moen, Kamiel Maase, Anton M. L. Coenen, Marijke C. M. Gordijn, Michiel A. J. Kompier
Summary: Research suggests that athletes often have poor sleep quality, but combining fixed sleep schedules with light regulation may lead to more consolidated sleep. Light regulation improved self-reported sleep onset latency and subjective sleep quality, especially with a strict sleep-wake schedule. However, less obtrusive methods should be explored to enhance protocol compliance.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2021)
Review
Clinical Neurology
Maxime Van Egroo, Ekaterina Koshmanova, Gilles Vandewalle, Heidi I. L. Jacobs
Summary: This article reviews the seminal studies from five decades ago that identified the brainstem locus coeruleus norepinephrine system as a key regulator of wakefulness and sleep. It discusses the various roles of this system in the organization of sleep-wake cycles and sleep microstructure, and explores the potential links between sleep-wake alterations and Alzheimer's disease. The article concludes by proposing research perspectives and opportunities for using the locus coeruleus norepinephrine system as a target for identifying individuals at risk of Alzheimer's disease and developing preventive interventions.
SLEEP MEDICINE REVIEWS
(2022)
Article
Multidisciplinary Sciences
Ya Chai, Zhuo Fang, Fan Nils Yang, Sihua Xu, Yao Deng, Andrew Raine, Jieqiong Wang, Meichen Yu, Mathias Basner, Namni Goel, Junghoon J. Kim, David A. Wolk, John A. Detre, David F. Dinges, Hengyi Rao
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Madison K. Titone, Brae Anne McArthur, Tommy H. Ng, Taylor A. Burke, Laura E. McLaughlin, Laura E. MacMullen, Namni Goel, Lauren B. Alloy
SCIENTIFIC REPORTS
(2020)
Article
Nutrition & Dietetics
Andrea M. Spaeth, Namni Goel, David F. Dinges
Review
Psychiatry
John F. Gottlieb, Namni Goel, Shenghao Chen, Michael A. Young
Summary: Sleep deprivation may be effective in treating bipolar depression, especially when used in conjunction with medication.
ACTA PSYCHIATRICA SCANDINAVICA
(2021)
Article
Endocrinology & Metabolism
Susan Kohl Malone, Amy J. Peleckis, Laura Grunin, Gary Yu, Sooyong Jang, James Weimer, Insup Lee, Michael R. Rickels, Namni Goel
Summary: The study aimed to describe long-term changes in glycemic control and objective sleep in adults with type 1 diabetes and hypoglycemia unawareness after initiating hybrid closed loop (HCL) insulin delivery. Results showed that HCL significantly reduced hypoglycemia occurrences and improved hypoglycemia awareness, but also led to delayed onset and shortened duration of sleep.
JOURNAL OF DIABETES RESEARCH
(2021)
Article
Clinical Neurology
Tess E. Brieva, Courtney E. Casale, Erika M. Yamazaki, Caroline A. Antler, Namni Goel
Summary: Various methods for defining cognitive deficits due to sleep restriction and total sleep deprivation are not equivalent. The Raw Score approach is a reliable method for distinguishing resilient and vulnerable groups during sleep loss based on performance in the Digit Symbol Substitution Test and Digit Span Test.
Article
Clinical Neurology
Courtney E. Casale, Erika M. Yamazaki, Tess E. Brieva, Caroline A. Antler, Namni Goel
Summary: This study aimed to compare different methods for defining resilience and vulnerability based on subjective metrics. The results showed that only the Raw Score approach consistently distinguished Resilient and Vulnerable groups, while the other approaches differed in their categorizations. The study suggests using the Raw Score approach as an effective method for subjective resilience/vulnerability categorization.
Article
Clinical Neurology
Tianxin Mao, David Dinges, Yao Deng, Ke Zhao, Zijing Yang, Hui Lei, Zhuo Fang, Fan Nils Yang, Olga Galli, Namni Goel, Mathias Basner, Hengyi Rao
Summary: Sleep deprivation impairs neurobehavioral functions such as vigilant attention and inhibition control. This study found that deficits in vigilant attention contribute to impairments in inhibition control after one night of total sleep deprivation and two nights of partial sleep restriction.
NATURE AND SCIENCE OF SLEEP
(2021)
Article
Clinical Neurology
Erika M. Yamazaki, Courtney E. Casale, Tess E. Brieva, Caroline A. Antler, Namni Goel
Summary: This study examined the impact of sleep loss on vigilant attention and categorized individuals' resiliency/vulnerability using three different approaches. The results showed that the approaches yielded similar results in classifying PVT lapses but had differences for 1/RT. Therefore, selecting appropriate methods and metrics is crucial for defining vigilant attention resiliency/vulnerability to sleep loss.
Review
Oncology
Elizabeth B. Klerman, Allison Brager, Mary A. Carskadon, Christopher M. Depner, Russell Foster, Namni Goel, Mary Harrington, Paul M. Holloway, Melissa P. Knauert, Monique K. LeBourgeois, Jonathan Lipton, Martha Merrow, Sara Montagnese, Mingming Ning, David Ray, Frank A. J. L. Scheer, Steven A. Shea, Debra J. Skene, Claudia Spies, Bart Staels, Marie-Pierre St-Onge, Steffen Tiedt, Phyllis C. Zee, Helen J. Burgess
Summary: The manuscript provides guidance on measuring metrics of endogenous circadian rhythms in humans and advocates for the inclusion of circadian rhythms assessments in health and disease studies. It describes protocols and analyses commonly used for studying human daily rhythms and recommends definitions and examples of circadian terminology.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Psychiatry
Logan T. Smith, Rachel F. L. Walsh, Namni Goel, Lauren B. Alloy
Summary: Social jetlag is significantly associated with differences in trajectories and lability of mood symptoms, particularly in individuals with high reward sensitivity and bipolar spectrum disorder. This study adds to the literature with methodological strengths such as ecological momentary assessment design and assessment of symptom and reward responsiveness trajectories.
PSYCHIATRY RESEARCH
(2023)
Article
Psychology, Biological
Tianxin Mao, Zhuo Fang, Ya Chai, Yao Deng, Joy Rao, Peng Quan, Namni Goel, Mathias Basner, Bowen Guo, David F. Dinges, Jianghong Liu, John A. Detre, Hengyi Rao
Summary: Sleep loss may impact risky decision-making by attenuating neural responses to decision outcomes and impairing the relationship between brain and behavior.
Article
Biology
Joshua S. Alwood, Ajitkumar P. Mulavara, Janani Iyer, Siddhita D. Mhatre, Susanna Rosi, Mark Shelhamer, Catherine Davis, Christopher W. Jones, Xiao Wen Mao, Rajeev I. Desai, Alexandra M. Whitmire, Thomas J. Williams
Summary: This article summarizes discussions on biomarkers and brain regions/circuits, including information on sensorimotor, behavioral medicine, and integrated approaches, and provides a summary of hundreds of biomarkers, serving as a rich resource for NASA's Human Research Program and the research community.
Review
Genetics & Heredity
Courtney E. Casale, Namni Goel
Summary: This paper discusses the impact of genotype on neurobehavioral responses to sleep deprivation, emphasizing the importance of the candidate gene approach in studying resilience and vulnerability in humans. Potential genetic indicators and the efficacy of countermeasures for sleep loss are also addressed in the review. Discovery of novel genetic markers has critical implications for future research in the field of sleep and circadian science.
Article
Clinical Neurology
Erika M. Yamazaki, Caroline A. Antler, Charlotte R. Lasek, Namni Goel
Summary: The study aimed to investigate the recovery patterns and differences after total sleep deprivation (TSD) and chronic sleep restriction (SR). Results showed that deficits in cognitive performance, self-reported sleepiness, and other measures were reversed after recovery sleep, except for some measures which failed to completely recover. This suggests that TSD and SR induce sustained, differential biological, physiological, and/or neural changes that are not reversed with chronic, long-duration recovery sleep.