NMR reveals the allosteric opening and closing of Abelson tyrosine kinase by ATP-site and myristoyl pocket inhibitors
出版年份 2013 全文链接
标题
NMR reveals the allosteric opening and closing of Abelson tyrosine kinase by ATP-site and myristoyl pocket inhibitors
作者
关键词
-
出版物
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 110, Issue 47, Pages E4437-E4445
出版商
Proceedings of the National Academy of Sciences
发表日期
2013-11-05
DOI
10.1073/pnas.1314712110
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Enhanced SH3/Linker Interaction Overcomes Abl Kinase Activation by Gatekeeper and Myristic Acid Binding Pocket Mutations and Increases Sensitivity to Small Molecule Inhibitors
- (2013) Shoghag Panjarian et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Signaling through dynamic linkers as revealed by PKA
- (2013) M. Akimoto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR–ABL including the T315I gatekeeper mutant
- (2011) Mathew Thomas et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036
- (2011) Wayne W. Chan et al. CANCER CELL
- Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis
- (2011) Florian Grebien et al. CELL
- Discovery and Characterization of a Cell-Permeable, Small-Molecule c-Abl Kinase Activator that Binds to the Myristoyl Binding Site
- (2011) Jingsong Yang et al. CHEMISTRY & BIOLOGY
- Mapping allostery through the covariance analysis of NMR chemical shifts
- (2011) R. Selvaratnam et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy
- (2011) L. R. Masterson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibitors of the Abl kinase directed at either the ATP- or myristate-binding site
- (2010) Doriano Fabbro et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- BCR-ABL SH3-SH2 domain mutations in chronic myeloid leukemia patients on imatinib
- (2010) D. W. Sherbenou et al. BLOOD
- Facile measurement of 1H–15N residual dipolar couplings in larger perdeuterated proteins
- (2010) Nicholas C. Fitzkee et al. JOURNAL OF BIOMOLECULAR NMR
- Solution Structure of the 128 kDa Enzyme I Dimer fromEscherichia coliand Its 146 kDa Complex with HPr Using Residual Dipolar Couplings and Small- and Wide-Angle X-ray Scattering
- (2010) Charles D. Schwieters et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Binding or Bending: Distinction of Allosteric Abl Kinase Agonists from Antagonists by an NMR-Based Conformational Assay
- (2010) Wolfgang Jahnke et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors
- (2010) Jianming Zhang et al. NATURE
- AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance
- (2009) Thomas O'Hare et al. CANCER CELL
- From biomolecular structure to functional understanding: new NMR developments narrow the gap
- (2009) Stephan Grzesiek et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- SH2 domains: modulators of nonreceptor tyrosine kinase activity
- (2009) Panagis Filippakopoulos et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Dynamics in the p38α MAP Kinase–SB203580 Complex Observed by Liquid-State NMR Spectroscopy
- (2008) Valerie S. Honndorf et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Backbone NMR resonance assignment of the Abelson kinase domain in complex with imatinib
- (2008) Navratna Vajpai et al. Biomolecular NMR Assignments
- Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation
- (2008) Panagis Filippakopoulos et al. CELL
- Solution Conformations and Dynamics of ABL Kinase-Inhibitor Complexes Determined by NMR Substantiate the Different Binding Modes of Imatinib/Nilotinib and Dasatinib
- (2008) Navratna Vajpai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started