Article
Oncology
Clemens An, Ilissa Pipia, Ana -Sofia Ruiz, Ivonne Arguelles, Martino An, Saima Wase, Guang Peng
Summary: Obesity is a major risk factor for cancers and recent research has focused on the relationship between dysregulated adipokines and cancer development. Adipose tissue, an important endocrine organ, secretes adipokines that modulate inflammation, induce insulin resistance, and regulate their own behavior and production. Dysregulation of adipokine production is caused by physiological changes in adipose tissue, including low-grade inflammation and reactive oxygen species. Furthermore, genomic instability, DNA damage response, and the innate immune response have been linked to tumorigenesis. Investigation of adipokines may clarify the link between obesity and cancer and identify potential pharmaceutical targets.
Review
Biochemistry & Molecular Biology
Bamidele A. Adesunloye
Summary: Obesity is associated with the risk of prostate cancer through mechanisms such as chronic low-level inflammation and biological changes that promote malignant transformation. Understanding these mechanisms may be valuable in developing effective prostate cancer prevention strategies and treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Ho Lee, Sang Myung Woo, Hyonchol Jang, Mingyu Kang, Soo-Youl Kim
Summary: The major source of reducing power for ADP in cancer remains unclear, but blocking fatty acid oxidation significantly decreases ATP production in cancer cells. Cancer cell growth mainly relies on metabolic nutrients and oxygen systemically supplied through the bloodstream instead of metabolic reprogramming.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Oncology
Morteza Gholami
Summary: This study identifies the FTO gene as a major shared gene between breast cancer, type 2 diabetes mellitus, and obesity based on two DNA repair and inflammatory mechanisms. These findings provide a new perspective on the important role of the FTO gene and repair mechanism in the relationship between these diseases.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Editorial Material
Endocrinology & Metabolism
Anna Peeters, Kathryn Backholer
Summary: Diet is a significant factor in noncommunicable diseases, and the relationship between diet quality and education, income, and food access remains inconclusive. A new study utilizing novel big data sources highlights the importance of addressing social determinants of health to improve population diets.
NATURE REVIEWS ENDOCRINOLOGY
(2022)
Article
Economics
Nathalie Mathieu-Bolh
Summary: Obesity has been a significant public health and policy issue for several decades, with literature pointing to both non-economic and economic factors as contributors. While poverty appears connected to obesity in affluent countries, empirical studies suggest a more complex relationship between income and obesity, which may vary as countries develop over time. Recent theoretical explanations have emerged to better understand this intricate link, aiming to provide a solid foundation for informed policy-making.
JOURNAL OF ECONOMIC SURVEYS
(2022)
Review
Biochemistry & Molecular Biology
Alice Chaplin, Ramon Maria Rodriguez, Juan Jose Segura-Sampedro, Aina Ochogavia-Segui, Dora Romaguera, Gwendolyn Barcelo-Coblijn
Summary: Obesity is a major risk factor for colorectal cancer, and visceral adipose tissue may play a key role in tumor development and progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Miao Pan, Ruiqing Tai, Yanrong Liu, Zhuwen Sun, Huan Yuan, Qiong Wu, Yongnian Liu, Chao Sun
Summary: Obesity is characterized by persistent low-level inflammation and insulin resistance, with pyroptosis playing a significant role in the pathogenesis of chronic inflammatory diseases. Targeting pyroptosis-related molecules may offer a new potential therapy for obesity-related inflammatory diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Oncology
Giovanna Muscogiuri, Eleonora Poggiogalle, Luigi Barrea, Maria G. Tarsitano, Francesco Garifalos, Alessia Liccardi, Gabriella Pugliese, Silvia Savastano, Annamaria Colao
Summary: Exposure to artificial light at night (ALAN) is associated with health risks, especially obesity and cancer. Suppression of melatonin secretion, circadian rhythm disruption, gut dysbiosis, and inflammation are among the mechanisms linking ALAN exposure to these diseases.
EUROPEAN JOURNAL OF CANCER
(2022)
Review
Nutrition & Dietetics
Razvigor Darlenski, Vesselina Mihaylova, Teodora Handjieva-Darlenska
Summary: Obesity is a multi-organ disease that affects the skin as well. This article discusses the skin changes in obese patients, including mechanical friction, infections, and hypertrophic conditions. The role of metabolic syndrome and obesity in the pathogenesis of chronic inflammatory skin diseases is also examined. Additionally, the impact of nutritional interventions on improving inflammatory skin diseases is highlighted.
FRONTIERS IN NUTRITION
(2022)
Review
Dentistry, Oral Surgery & Medicine
Ferda Pamuk, Alpdogan Kantarci
Summary: Nutrition is crucial for maintaining homeostatic balance, health, and longevity, and is closely linked to inflammatory diseases and obesity. Obesity has severe implications on various organ systems and disease processes, but its impact on periodontal inflammation and the association between nutritional balance and periodontal inflammation require further exploration.
PERIODONTOLOGY 2000
(2022)
Review
Medicine, General & Internal
Jakub Golacki, Malgorzata Matuszek, Beata Matyjaszek-Matuszek
Summary: Insulin resistance has become a common health issue, closely associated with obesity. However, there is a lack of clear data on its prevalence and diagnostic criteria, leading to overdiagnosis and inappropriate treatment. This review provides insights into the pathophysiology of insulin resistance, its relationship with obesity, as well as diagnostic methods, clinical presentation, and treatment options, emphasizing the importance of nutrition changes and regular physical activity for effective management.
Review
Oncology
Nakul J. Bhardwaj, Kacey Chae, Jennifer Y. Sheng, Hsin-Chieh Yeh
Summary: Excess body weight is a significant risk factor for the development and recurrence of many types of cancer. Weight loss and maintaining a healthy body weight can reduce complications and recurrence for cancer patients.
CANCER AND METASTASIS REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Jorge Gutierrez-Cuevas, Arturo Santos, Juan Armendariz-Borunda
Summary: Obesity is a global epidemic associated with various comorbidities, such as MAFLD, NASH, and CVD, with T2D being a common link between MAFLD/NASH and CVD. Understanding the underlying pathophysiological mechanisms is crucial for developing effective strategies to prevent and treat these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Helena Sanchez-Ortega, Carlos Jimenez-Cortegana, Jose P. Novalbos-Ruiz, Ana Gomez-Bastero, Jose G. Soto-Campos, Victor Sanchez-Margalet
Summary: Asthma and obesity are highly prevalent diseases with a significant impact on public health. Obesity exacerbates the development and severity of asthma through the secretion of proinflammatory cytokines and mediators, such as leptin, by adipose tissue. This systematic review and meta-analysis examine the relationship between leptin and asthma during obesity. The results indicate significant differences in leptin levels and support the relevant role of leptin in the pathophysiology of asthma in obese individuals. Further studies are needed to better understand the relationship between leptin and asthma in obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)