Article
Clinical Neurology
Forouzan Farahani, Greg Kronberg, Mohamad FallahRad, Hysell V. Oviedo, Lucas C. Parra
Summary: This study found that transcranial direct current stimulation (DCS) enhances synaptic plasticity by increasing postsynaptic somatic spiking, but also discovered that an increase in network activity may both boost and limit this enhancement.
Article
Neurosciences
M. Mar Reus-Garcia, Raudel Sanchez-Campusano, Julia Ledderose, Godwin K. Dogbevia, Mario Trevino, Mazahir T. Hasan, Agnes Gruart, Jose M. Delgado-Garcia
Summary: The claustrum (CL) is believed to be involved in sensorimotor integration and cognitive processes. Through recordings in rabbits during classical eyeblink conditioning, CL neurons were found to be significantly modulated during early sessions of CS/US presentations but not in well-trained animals. The CL appears to play a crucial role in the acquisition of associative learning, particularly in relation to the novelty of CS/US associations.
Review
Clinical Neurology
Sohaib Ali Korai, Federico Ranieri, Vincenzo Di Lazzaro, Michele Papa, Giovanni Cirillo
Summary: This review focuses on the molecular and cellular mechanisms of transcranial direct and alternating current stimulation, highlighting changes in membrane potential, neural synchronization, protein synthesis, and the role of glial cells in synaptic plasticity. Research from in vitro and in vivo studies in animals and humans provide insights into possible pathways for the development of targeted therapeutic applications.
FRONTIERS IN NEUROLOGY
(2021)
Review
Neurosciences
Laura K. Olsen, Ernesto Solis Jr, Lindsey K. McIntire, Candice N. Hatcher-Solis
Summary: Vagus nerve stimulation (VNS) is a useful neuromodulation tool that can target the central nervous system by stimulating peripheral nerves. It can modulate various higher order brain regions, including the limbic and cerebral cortex structures, by activating the nucleus of the solitary tract in the brainstem. Clinical and preclinical studies have shown that VNS can improve memory.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Neurosciences
Alesha Heath, Michelle Madore, Karina Diaz, M. Windy Mcnerney
Summary: This study investigates the effects of hindbrain-targeted rTMS stimulation in mice and finds that it can alter motor, cognitive, and anxiety measures. It also demonstrates that the improved processing speed in the object recognition test is achieved through structural plasticity mechanisms in the hippocampus.
Article
Multidisciplinary Sciences
Katarina Vulic, Jovana Bjekic, Dunja Paunovic, Milos Jovanovic, Sladan Milanovic, Sasa R. Filipovic
Summary: This study demonstrates that there is potential for oscillatory tDCS protocols to enhance memory, producing strong and reliable effects on memory modulation. Individual-level analysis revealed that some participants responded differently to theta-oscillatory tDCS compared to constant tDCS, suggesting different physiological mechanisms at play. Further investigation into the efficacy of oscillatory tDCS for memory enhancement is warranted.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Hang Wang, Xianghuan Dong, Maher Un Nisa Awan, Jie Bai
Summary: This review briefly summarizes the studies on epigenetics involved in METH addiction, elucidating the molecular mechanism of METH addiction and the effects of METH on neurotransmitter release and brain area activation.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Clinical Neurology
Giordano D'Urso, Elena Toscano, Annarita Barone, Mario Palermo, Bernardo Dell'Osso, Giorgio Di Lorenzo, Antonio Mantovani, Giovanni Martinotti, Michele Fornaro, Felice Iasevoli, Andrea de Bartolomeis
Summary: Despite multiple available treatments for bipolar depression, many patients do not respond well. Transcranial direct current stimulation (tDCS) has shown promise in treating resistant cases, although further research is needed to determine optimal dosing, timing, and safety considerations.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Jiayue Cheng, Puyu Li, Yingying Tang, Chen Zhang, Liangjun Lin, Jian Gao, Zhen Wang
Summary: The study showed that high-definition tDCS treatment in OCD patients can significantly improve symptoms, and the treatment can lead to improvements in GABAB receptor function.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Pharmacology & Pharmacy
Bruno Rodrigues, Catarina A. Barboza, Eliezer G. Moura, Gabriela Ministro, Silvia E. Ferreira-Melo, Javier B. Castano, Olivia M. Ruberti, Rivadavio F. B. De Amorim, Heitor Moreno
Summary: The study suggests that transcranial direct current stimulation (tDCS) can lead to positive acute adjustments in cardiac autonomic control and reduced 24-hour blood pressure values in hypertensive patients. These results may indicate a potential future application of brain stimulation (tDCS) in treating refractory hypertension syndromes.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Clinical Neurology
Petyo Nikolov, Thomas J. Baumgarten, Shady S. Hassan, Sarah N. Meissner, Nur-Deniz Fuellenbach, Gerald Kircheis, Dieter Haessinger, Markus S. Joerdens, Markus Butz, Alfons Schnitzler, Stefan J. Groiss
Summary: The study revealed reduced synaptic plasticity of the primary motor cortex in patients with hepatic encephalopathy (HE), likely caused by disturbances in glutamatergic neurotransmission due to hyperammonemia in HE patients. This decrease in synaptic plasticity may provide a link between molecular level changes and early clinical symptoms of the disease.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jin Seung Choung, Sohom Bhattacharjee, Jeong Pyo Son, Jong Moon Kim, Dong Sik Cho, Choon Sik Cho, MinYoung Kim
Summary: Repetitive transcranial magnetic stimulation (rTMS) is being explored as a new treatment technique for brain lesions, but the effects in animals cannot directly represent the effects in humans due to differences in size and mechanistic characteristics. This study aimed to develop a mouse rTMS device to simulate clinical application. The magnetic field intensity generated by the mouse coil was lower than that by the human coil, and the predicted simulation values matched the measured intensity in vivo. Further research using miniaturized rTMS devices for mice should be conducted to make the findings more relevant to humans.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Shane M. Fresnoza, Giorgi Batsikadze, Lynn Elena Mueller, Constanze Rost, Michael Chamoun, Walter Paulus, Min-Fang Kuo, Michael A. Nitsche
Summary: Dopamine plays a crucial role in neuroplasticity and has dosage-dependent effects on motor cortex plasticity. Different dosages of dopamine precursor such as L-DOPA can either impair, abolish, preserve, or reverse plasticity in healthy individuals. Similarly, selective D1-like and D2-like receptor activation has excitatory and inhibitory effects on plasticity. However, the effects of nonselective dopamine agonists like apomorphine on plasticity have not been extensively explored in humans.
Article
Medicine, General & Internal
Seong Hoon Bae, Seo Jin Moon, Jeong Gum Lee, Yun Kyung Yim, Hee So Oh, Dong Hee Han, In Seok Moon
Summary: The study compared the effects of rTMS and tDCS treatments for chronic tinnitus, showing comparable results in reducing tinnitus symptoms, with tDCS possibly being more cost-effective.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Roderick P. P. W. M. Maas, Dennis J. L. G. Schutter, Ivan Toni, Dagmar Timmann, Bart P. C. van de Warrenburg
Summary: This study investigated whether repeated sessions of cerebellar transcranial direct current stimulation (tDCS) can modify the acquisition and/or timing of conditioned eyeblink responses (CRs) in patients with spinocerebellar ataxia type 3 (SCA3). The results showed that cerebellar tDCS had a significant treatment effect on the timing parameters of CRs, but did not affect CR acquisition. It was also found that the severity of disease measures and the duration of the disease were associated with the timing of CRs.
Article
Clinical Neurology
Harper Lee Kaye, Daniel San-Juan, Ricardo Salvador, Maria Chiara Biagi, Laura Dubreuil-Vall, Ugur Damar, Alvaro Pascual-Leone, Giulio Ruffini, Mouhsin M. Shafi, Alexander Rotenberg
Summary: This study demonstrates the safety and efficacy of multifocal, personalized, multichannel cathodal transcranial direct current stimulation in reducing seizure frequency in patients with drug-resistant focal epilepsy. However, there is a possibility of seizure exacerbation in some patients.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Sahar Allouch, Maxime Yochum, Aya Kabbara, Joan Duprez, Mohamad Khalil, Fabrice Wendling, Mahmoud Hassan, Julien Modolo
Summary: Understanding brain-scale functional networks through EEG source connectivity is crucial for neuroscience research. A recently developed model named COALIA provides realistic simulations for analyzing cortical networks. High electrode density and specific algorithms for solving inverse problems, along with functional connectivity measures, have shown promising results for accurately estimating cortical networks in the context of epileptiform activity.
Article
Engineering, Biomedical
Borja Mercadal, Ricardo Salvador, Maria Chiara Biagi, Fabrice Bartolomei, Fabrice Wendling, Giulio Ruffini
Summary: This study examines the impact of metal implants on electrical stimulation techniques and provides a theoretical argument for choosing the correct representation of metal implants in electrical models. The results demonstrate that metal implants exhibit different behaviors under different electric fields, and using an incorrect model for metal implants can lead to significant errors in dosimetry assessment. Therefore, selecting the appropriate model is crucial in each scenario.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Neurosciences
Lucia Mencarelli, Lucia Monti, Sara Romanella, Francesco Neri, Giacomo Koch, Ricardo Salvador, Giulio Ruffini, Giulia Sprugnoli, Simone Rossi, Emiliano Santarnecchi
Summary: This study found that stimulating the left and right DLPFC with 40 Hz tACS can increase blood oxygenation level-dependent activity in the targeted DLPFCs and surrounding areas according to biophysical modeling. However, off-target effects on visual cortices, SMA, left subgenual cingulate, and right superior temporal gyrus were also observed.
Article
Engineering, Biomedical
Elif Koksal-Ersoz, Remo Lazazzera, Maxime Yochum, Isabelle Merlet, Julia Makhalova, Borja Mercadal, Roser Sanchez-Todo, Giulio Ruffini, Fabrice Bartolomei, Pascal Benquet, Fabrice Wendling
Summary: This study investigates the generation mechanisms of IEDs in partial epilepsies through signal analysis and mathematical modeling. The researchers identify two classes of SWs and determine their distribution in epileptic and non-epileptic zones. The modeling results suggest a correlation between the morphology of IEDs and the degree of inhibition preservation.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Engineering, Biomedical
Borja Mercadal, Edmundo Lopez-Sola, Adria Galan-Gadea, Mariam Al Harrach, Roser Sanchez-Todo, Ricardo Salvador, Fabrice Bartolomei, Fabrice Wendling, Giulio Ruffini
Summary: This study proposes a framework for combining multi-compartment modeling and a detailed geometrical model to simulate transmembrane currents in cortical neurons. Based on this framework, they connect neural mass models with a volume conductor model and simulate an example of SEEG signal. The results highlight the importance of including a physical model in neural mass models to improve the accuracy of predicted electrophysiological recordings.
JOURNAL OF NEURAL ENGINEERING
(2023)
Review
Behavioral Sciences
Gloria G. Parras, Rocio Leal-Campanario, Juan C. Lopez-Ramos, Agnes Gruart, Jose M. Delgado-Garcia
Summary: Classical conditioning of nictitating membrane/eyelid responses has been used as a model to study how the brain organizes the acquisition, storage, and retrieval of motor abilities. Multiple brain areas have been found to be involved in this type of learning. This study specifically focuses on the functional roles of three brain structures involved in the acquisition and performance of eyelid conditioned responses, as well as three other brain structures related to non-motor aspects of the acquisition process.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Biochemical Research Methods
Giulio Ruffini, Giada Damiani, Diego Lozano-Soldevilla, Nikolas Deco, Fernando E. E. Rosas, Narsis A. A. Kiani, Adrian Ponce-Alvarez, Morten L. L. Kringelbach, Robin Carhart-Harris, Gustavo Deco
Summary: In this study, the authors characterized two brain states (psychedelics-induced and placebo) using functional magnetic resonance imaging (fMRI) data and features from the Ising model formalism and algorithmic complexity. They found that psychedelics increased BOLD signal complexity and Ising temperature, in agreement with previous findings and predictions. They also discovered that the placebo condition was already in a paramagnetic phase, while ingestion of psychedelics resulted in a shift towards a more disordered state. The study highlights the recovery of the structural connectome through fitting an Ising model and the role of reduced homotopic links in psychedelics-induced disorder.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Engineering, Biomedical
N. Gentilal, A. Naveh, T. Marciano, P. C. Miranda
Summary: The study investigated the impact of accounting for scalp temperature during treatment planning on the choice of the best layout suggested by NovoTAL, as well as the sensitivity of the results to the evaluation criteria. The results showed that considering temperature does not significantly affect the best layout choice as long as the arrays are at least 1 cm apart. Additionally, the choice of the best layout depends on the evaluation criteria used.
Article
Engineering, Biomedical
Adria Galan-Gadea, Ricardo Salvador, Fabrice Bartolomei, Fabrice Wendling, Giulio Ruffini
Summary: We provide a systematic framework for quantifying the effect of weak electric fields on realistic neuron compartment models and determine their orientation-dependent responses. Through simulations using reconstructions of the rat somatosensory cortex, we estimate response function values and analyze the angular response as an expansion in spherical harmonics.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fabiola Alonso, Borja Mercadal, Ricardo Salvador, Giulio Ruffini, Fabrice Bartolomei, Fabrice Wendling, Julien Modolo
Summary: Intracranial electrodes are used clinically for various purposes, such as drug-refractory epilepsy. However, quantifying the electric fields induced by electrical stimulation is challenging due to various factors. This study aimed to evaluate different biophysical models for characterizing the electric fields in patients undergoing pre-surgical evaluation. The results provide insights into developing accurate patient-specific models for neuromodulation and neurostimulation procedures.
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS
(2023)
Article
Computer Science, Cybernetics
Pau Clusella, Elif Koksal-Ersoz, Jordi Garcia-Ojalvo, Giulio Ruffini
Summary: Neural mass models (NMMs) aim to replicate the collective dynamics of neuronal populations. A common framework assumes that the firing rate of a population can be described by a static nonlinear transfer function. However, a recent theory challenges this view by showing that the firing rate follows nonlinear differential equations. This study analyzes and compares these two descriptions in the presence of second-order synaptic dynamics.
BIOLOGICAL CYBERNETICS
(2023)