Review
Immunology
Oktay Genel, Carmine M. Pariante, Alessandra Borsini
Summary: Modulation of the AQP4 water-regulatory channel and autoantibodies have been implicated in neuropsychiatric conditions, but the interaction with depression remains unclear. Experimental studies suggest that stress or inflammation can decrease AQP4 expression in various brain regions, while AQP4 may play a role in preventing negative effects on neurogenesis and gliogenesis. Clinical studies did not show significant differences in depressed patients in terms of AQP4 expression or autoantibodies compared to controls. Future research should further explore the mechanisms of AQP4 and its potential role in depression.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Ana del Puerto, Julia Pose-Utrilla, Ana Simon-Garcia, Celia Lopez-Menendez, Antonio J. Jimenez, Eva Porlan, Luis S. M. Pajuelo, Guillermo Cano-Garcia, Beatriz Marti-Prado, Alvaro Sebastian-Serrano, Marina P. Sanchez-Carralero, Fabrizia Cesca, Giampietro Schiavo, Isidro Ferrer, Isabel Farinas, Miguel R. Campanero, Teresa Iglesias
Summary: Kidins220 is a critical regulator of cerebrospinal fluid homeostasis, and its deficiency can lead to ventriculomegaly and dysregulation of water balance, affecting the expression of AQP4.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Jessica Correa Bezerra Bellei, Nicolas Glanzmann, Barbara Albuquerque Carpinter, Daniela Chaves Renhe, Carolina Brandi Marques, Marina Rocha Azevedo, Livia Maria Barreto, Vinicius Novaes Rocha, Isabelle Karine da Costa Nunes, Henrique Marcelo Gualberto Pereira, Elaine Soares Coimbra, Eduardo Antonio Ferraz Coelho, Adilson David da Silva, Fernando de Pilla Varotti, Kezia Katiani Gorza Scopel
Summary: Chloroquine remains the most effective drug for malaria treatment, although resistance to it has emerged. This study focuses on the synthesis of quinoline derivatives to develop new antimalarials. Compound 3 showed promising activity against malaria, inhibiting parasite growth and protecting against severe malaria development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Neurosciences
Dan-Dan Zhu, Guang Yang, Yue-Lin Huang, Ting Zhang, Ao-Ran Sui, Na Li, Wei-Heng Su, Hai-Lun Sun, Jing-Jing Gao, Michael Ntim, Rong-Xiao Guan, Ling-Ling Jin, Jian Yu, Zhi-Yong Huang, Tong-Hui Ma, Shao Li
Summary: This study developed a mouse model with depolymerized orthogonal arrays of particles (OAPs) to investigate the importance of OAP formation in Aquaporin-4 (AQP4). The results showed that the OAP structure of AQP4 plays a key role in its polarized expression in astrocytic endfeet processes at the blood-brain barrier. Manipulating the OAP formation of AQP4 may provide a new intervention strategy for cerebral cellular edema caused by stroke and traumatic brain injury.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemical Research Methods
Aleena Das, Welka Sahu, Deepak Kumar Ojha, K. Sony Reddy, Mrutyunjay Suar
Summary: An untargeted metabolomics approach was used to identify the changes in metabolic pathways and metabolites in the serum of mice with different pathological stages of malaria. The study provides insights into the host biology during malaria and could be helpful for the selection of animal models for evaluating diagnostic and therapeutic interventions against malaria.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Neurosciences
Petra Sucha, Zuzana Hermanova, Martina Chmelova, Denisa Kirdajova, Sara Camacho Garcia, Valeria Marchetti, Ivan Vorisek, Jana Tureckova, Eyar Shany, Daniel Jirak, Miroslava Anderova, Lydia Vargova
Summary: This study investigated the interaction between astrocytic Aquaporin 4 (AQP4) and Transient receptor potential vanilloid 4 (TRPV4) channels and their impact on brain injury after stroke. The results showed that deleting AQP4 or TRPV4 channels alone worsened the ischemic brain injury, while deleting both channels resulted in a smaller initial brain lesion but similar tissue damage in the later phase as compared to controls. The study suggests that the interplay between AQP4 and TRPV4 channels plays a critical role in neuronal and non-neuronal swelling after ischemic injury.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Ripandeep Kaur, Varun Gorki, Guneet Singh, Ranjot Kaur, O. P. Katare, Niroshini Nirmalan, Bhupinder Singh
Summary: The research aimed to develop a rapid therapy for cerebral malaria using intranasal delivery of artemether and lumefantrine, which demonstrated enhanced drug concentration in the brain and effective parasitic suppression.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Teresa F. Pais, Hajrabibi Ali, Joana Moreira da Silva, Nadia Duarte, Rita Neres, Chintan Chhatbar, Rita C. Acurcio, Rita C. Guedes, Maria Carolina Strano Moraes, Bruno Costa-Silva, Ulrich Kalinke, Carlos Penha-Goncalves
Summary: In this study, the researchers identified STING1 as a key factor in inducing IFN beta 1 transcription in the mouse brain infected with Plasmodium berghei ANKA. This STING1/IFN beta response increased the levels of CXCL10 in the brain, which in turn affected the extent of leukocyte infiltration and blood-brain barrier breakdown, ultimately determining the lethality of CM.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Tarun Keswani, Aisha Obeidallah, Edward Nieves, Simone Sidoli, Melissa Fazzari, Terrie Taylor, Karl Seydel, Johanna P. Daily
Summary: This study explored the metabolic etiology of cerebral malaria coma and found abnormal concentrations of pipecolic acid (PA) in the plasma of CM patients, which were associated with renal insufficiency. PA levels were found to be correlated with normal behavior and blood-brain barrier (BBB) permeability in animal models. The findings suggest that malaria-generated PA induces coma in CM and ECM.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Shweta Rai, Meetali Girdhar, Fouzia Siraj, Sheetal Sharma, Mukesh Kumar, Anju Katyal
Summary: This study aimed to dissect and differentiate the immunopathogenesis of cerebral malaria in young BALB/c and C57BL/6J mice infected with Plasmodium berghei ANKA (PbA), in search of a mouse model mimicking pediatric cerebral malaria. The results showed that young BALB/c mice had a severe course of infection and typical histopathological alterations, such as monocytic plugging, compared to C57BL/6J mice. BALB/c mice also exhibited decreased blood-brain barrier permeability and increased expression of pro/anti-inflammatory cytokines. These findings suggest that the imbalance of cytokine expression contributes to the worsening of disease manifestation in young BALB/c mice, similar to pediatric cerebral malaria.
IMMUNOLOGY LETTERS
(2023)
Article
Immunology
Ian J. C. MacCormick, Valentina Barrera, Nicholas A. Beare, Gabriela Czanner, Michael Potchen, Samuel Kampondeni, Robert S. Heyderman, Alister G. Craig, Malcolm E. Molyneux, Macpherson Mallewa, Valerie A. White, Dan Milner, Paul Hiscott, Terrie E. Taylor, Karl B. Seydel, Simon P. Harding
Summary: In cerebral malaria, retinal vascular leakage is associated with brain swelling and death. Retinal blood vessel rupture can cause cerebral hemorrhage and brain swelling, while vessel leak and barrier dysfunction are associated with neurological deficits.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Takashi Imai, Ha Ngo-Thanh, Kazutomo Suzue, Aoi Shimo, Akihiro Nakamura, Yutaka Horiuchi, Hajime Hisaeda, Takashi Murakami
Summary: This study aims to develop a malaria vaccine that provides cross-strain protection. Results showed that inoculation of mice with a heterologous live-vaccine prevented the development of experimental cerebral malaria (ECM) and protected the blood-organ barriers from infection. The immune response induced by the live vaccine included cross-reactive antibodies and IL-10-mediated host protection against ECM.
Review
Biochemistry & Molecular Biology
Irene Bulli, Ilaria Dettori, Elisabetta Coppi, Federica Cherchi, Martina Venturini, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Alessio Nocentini, Claudiu T. Supuran, Anna Maria Pugliese, Felicita Pedata
Summary: The review summarizes the role of carbonic anhydrase inhibitors in strokes and discusses their potential protective mechanisms, highlighting them as possible new pharmacological agents for the management of brain ischemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Jade Royo, Aissata Camara, Benedicte Bertrand, Philippe Batigne, Agnes Coste, Bernard Pipy, Agnes Aubouy
Summary: Monocytes accumulate in the brain microvasculature during cerebral malaria (CM) and exhibit different behaviors during infection and resolution. Increasing the expressions of specific proteins in the brain contributes to the resolution of neuroinflammation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ya Tian, Zhongyuan Zheng, Xi Wang, Shuzhi Liu, Liwei Gu, Jing Mu, Xiaojun Zheng, Yujie Li, Shuo Shen
Summary: Cerebral malaria is a life-threatening neurological complication caused by Plasmodium falciparum. Current treatments using artemisinin and its derivatives are not effective in targeting the brain. This study explored a new approach by using a brain-targeted nano-delivery system. The results showed that the brain-targeted liposomes had a higher fluorescence intensity in the mouse brain and improved treatment outcomes. Pharmacokinetic analysis demonstrated that the brain-targeted liposomes could enter the brain through both systemic circulation and nasal-brain pathway. This research provides valuable insights for the treatment of cerebral malaria.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Anatomy & Morphology
Eystein Hellstrom Hoddevik, Faraz Hameed Khan, Soulmaz Rahmani, Ole Petter Ottersen, Henning Bunsow Boldt, Mahmood Amiry-Moghaddam
BRAIN STRUCTURE & FUNCTION
(2017)
Letter
Medicine, General & Internal
Espen Bjertness, Thein Thein Htay, Nay Soe Maung, Zaw Wai Soe, Saw Sanda Aye, Ole Petter Ottersen, Tippawan Liabsuetrakul, Per Grottum, Magnus Hovland, Mahmood Amiry-Moghaddam
Article
Radiology, Nuclear Medicine & Medical Imaging
Svein Are Sirirud Vatnehol, Per Kristian Hol, Atle Bjornerud, Mahmood Amiry-Moghaddam, Camilla Haglerod, Tryggve Holck Storas
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2019)
Article
Neurosciences
Shreyas B. Rao, Shirin Katoozi, Nadia Skauli, Stanley C. Froehner, Ole Petter Ottersen, Marvin E. Adams, Mahmood Anniry-Moghaddann
Editorial Material
Oncology
Mahmood Amiry-Moghaddam
Article
Radiology, Nuclear Medicine & Medical Imaging
Svein Are Sirirud Vatnehol, Per Kristian Hol, Atle Bjornerud, Mahmood Amiry-Moghaddam, Camilla Haglerod, Tryggve Holck Storas
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2020)
Article
Anatomy & Morphology
Eystein Hellstrom Hoddevik, Shreyas Balachandra Rao, Soulmaz Zahl, Henning Bunsow Boldt, Ole Petter Ottersen, Mahmood Amiry-Moghaddam
BRAIN STRUCTURE & FUNCTION
(2020)
Article
Biochemistry & Molecular Biology
Claudia Palazzo, Pasqua Abbrescia, Onofrio Valente, Grazia Paola Nicchia, Shervin Banitalebi, Mahmood Amiry-Moghaddam, Maria Trojano, Antonio Frigeri
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Svein Are Sirirud Vatnehol, Per Kristian Hol, Atle Bjornerud, Mahmood Amiry-Moghaddam, Camilla Haglerod, Tryggve Holck Storas
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2020)
Article
Cell Biology
Shirin Katoozi, Nadia Skauli, Soulmaz Zahl, Tushar Deshpande, Pascal Ezan, Claudia Palazzo, Christian Steinhaeuser, Antonio Frigeri, Martine Cohen-Salmon, Ole Petter Ottersen, Mahmood Amiry-Moghaddam
Article
Neurosciences
Shirin Katoozi, Shreyas B. Rao, Nadia Skauli, Stanley C. Froehner, Ole Petter Ottersen, Marvin E. Adams, Mahmood Amiry-Moghaddam
Article
Biochemistry & Molecular Biology
Soulmaz Zahl, Nadia Skauli, Katja Stahl, Agnete Prydz, Mina Martine Frey, Erik Dissen, Ole Petter Ottersen, Mahmood Amiry-Moghaddam
Summary: Our study reveals that AQP9 plays a proinflammatory role in the brain and is expressed in microglial cells. This research opens new avenues for studying neuroinflammation and chronic neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Shervin Banitalebi, Nadia Skauli, Samuel Geiseler, Ole Petter Ottersen, Mahmood Amiry-Moghaddam
Summary: This study investigates the mechanisms of scar formation in the brain and finds pronounced changes in the astrocytic protein AQP4 in the infarct border zone, which may be related to the downregulation of the AQP4 isoform AQP4ex. These findings provide new insights into the molecular basis of scar formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Agnete Prydz, Katja Stahl, Soulmaz Zahl, Nadia Skauli, Oivind Skare, Ole Petter Ottersen, Mahmood Amiry-Moghaddam
Article
Anatomy & Morphology
Shirin Katoozi, Nadia Skauli, Soulmaz Rahmani, Laura M. A. Camassa, Henning B. Boldt, Ole P. Ottersen, Mahmood Amiry-Moghaddam
BRAIN STRUCTURE & FUNCTION
(2017)