Review
Biochemistry & Molecular Biology
Gerga Gogl, Alexandr P. Kornev, Attila Remenyi, Susan S. Taylor
TRENDS IN BIOCHEMICAL SCIENCES
(2019)
Review
Biochemistry & Molecular Biology
Susan S. Taylor, Hiruy S. Meharena, Alexandr P. Kornev
Review
Biochemistry & Molecular Biology
Lalima G. Ahuja, Susan S. Taylor, Alexandr P. Kornev
Article
Multidisciplinary Sciences
Sven H. Schmidt, Matthias J. Knape, Daniela Boassa, Natascha Mumdey, Alexandr P. Kornev, Mark H. Ellisman, Susan S. Taylor, Friedrich W. Herberg
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Multidisciplinary Sciences
Lalima G. Ahuja, Phillip C. Aoto, Alexandr P. Kornev, Gianluigi Veglia, Susan S. Taylor
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Genetics & Heredity
Pedro M. Rodriguez Cruz, Judith Cossins, Jonathan Cheung, Susan Maxwell, Sandeep Jayawant, Ruth Herbst, Dominic Waithe, Alexandr P. Kornev, Jacqueline Palace, David Beeson
Review
Biochemistry & Molecular Biology
Susan S. Taylor, Jian Wu, Jessica G. H. Bruystens, Jason C. Del Rio, Tsan-Wen Lu, Alexandr P. Kornev, Lynn F. Ten Eyck
Summary: The Protein Data Bank has played a crucial role in the signaling community for over 30 years, facilitating information sharing between academics and industry. Through the study of protein kinases, particularly cAMP-dependent protein kinase, researchers have made significant discoveries including the importance of crystal packing in biological processes and disease relevance. Integrating crystallography with other techniques is opening up new possibilities for understanding intrinsically disordered regions and dynamic biological processes.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Timothy R. Baffi, Gema Lorden, Jacob M. Wozniak, Andreas Feichtner, Wayland Yeung, Alexandr P. Kornev, Charles C. King, Jason C. Del Rio, Ameya J. Limaye, Julius Bogomolovas, Christine M. Gould, Ju Chen, Eileen J. Kennedy, Natarajan Kannan, David J. Gonzalez, Eduard Stefan, Susan S. Taylor, Alexandra C. Newton
Summary: The study identified a mTOR-mediated phosphorylation site known as TOR interaction motif (TIM) that regulates the phosphorylation and activity of PKC and Akt. The TIM is invariant in mTORC2-dependent AGC kinases and plays a crucial role in kinase activity.
Article
Multidisciplinary Sciences
Alexandr P. Kornev, Phillip C. Aoto, Susan S. Taylor
Summary: The topological analysis of protein residue networks is a useful method for understanding the roles of individual residues. In this study, the researchers used protein kinase A as a study object and found that using local spatial pattern alignment could detect functionally important residues in the protein residue network.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Chemistry, Physical
Lalima K. K. Madan, Colin L. L. Welsh, Alexandr P. P. Kornev, Susan S. S. Taylor
Summary: Allosteric regulation of proteins is an engaging research topic that has evolved from focusing on structural changes to considering internal protein dynamics. The violin model, based on redistribution of protein thermal fluctuations, utilizes graph theory and community network analysis to cluster correlated protein motions. This Review provides the theory and workflow of the methodology and illustrates its application to protein kinase A.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Caila A. Pilo, Timothy R. Baffi, Alexandr P. Kornev, Maya T. Kunkel, Mario Malfavon, Dong-Hui Chen, Leigh -Ana Rossitto, Daniel X. Chen, Liang-Chin Huang, Cheryl Longman, Natarajan Kannan, Wendy H. Raskind, David J. Gonzalez, Susan S. Taylor, George Gorrie, Alexandra C. Newton
Summary: Spinocerebellar ataxia type 14 is a neurodegenerative disease caused by mutations in the PKCy gene, which disrupts the autoinhibition of the protein kinase and leads to cerebellar dysfunction.
Article
Biochemistry & Molecular Biology
Alexander C. Jones, Susan S. Taylor, Alexandra C. Newton, Alexandr P. Kornev
Meeting Abstract
Biophysics
Caila A. Pilo, Maya T. Kunkel, An-Angela N. Van, Evan K. Kobori, Alexandr P. Kornev, Cheryl Longman, George Gorrie, Susan S. Taylor, Alexandra C. Newton
BIOPHYSICAL JOURNAL
(2020)
Meeting Abstract
Biophysics
Alexandr P. Kornev
BIOPHYSICAL JOURNAL
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Lalima G. Ahuja, Yilin Meng, Alexandr P. Kornev, Benoit Roux, Susan Taylor