Small changes in enzyme function can lead to surprisingly large fitness effects during adaptive evolution of antibiotic resistance

FREQ-Seq: A Rapid, Cost-Effective, Sequencing-Based Method to Determine Allele Frequencies Directly from Mixed Populations

(2012) Lon M. Chubiz et al.   PLoS One

The Molecular Diversity of Adaptive Convergence

(2012) O. Tenaillon et al.   SCIENCE

Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase

(2011) Gesa Volkers et al.   FEBS LETTERS

Evolutionary fates within a microbial population highlight an essential role for protein folding during natural selection

(2011) Matthew I Peña et al.   Molecular Systems Biology

Crystal structure of Bacteroides thetaiotaomicron TetX2: A tetracycline degrading monooxygenase at 2.8 Å resolution

(2011) Katarzyna Walkiewicz et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Mutational effects and the evolution of new protein functions

(2010) Misha Soskine et al.   NATURE REVIEWS GENETICS

Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli

(2009) Bryson D Bennett et al.   Nature Chemical Biology

Exploring protein fitness landscapes by directed evolution

(2009) Philip A. Romero et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY